| Entrez gene ID | | 24842 |
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| Official gene symbol | | Tp53 |
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| Full name | | tumor protein p53 |
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| Aliases | | MGC112612,Trp53,p53 |
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| Gene summary | | This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it is believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Alternatively spliced transcript variants have been found for this gene, but the biological validity of the variants has not been determined. p53 pseudogenes have been found on chromosomes 9 and 18. [provided by RefSeq] |
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| Location | | Chromosome: 10 Locus: 10q24 |
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| Gene position | | 56399720 - 56411149 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 11430 bp |
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| Gene sequence |
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