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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for Tp53 (Rattus norvegicus)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0000060protein import into nucleus, translocationISO
GO:0000122negative regulation of transcription from RNA polymerase II promoterIBA
GO:0000122negative regulation of transcription from RNA polymerase II promoterISO
GO:0000733DNA strand renaturationISO
GO:0000733DNA strand renaturationISS
GO:0001701in utero embryonic developmentISO
GO:0001756somitogenesisISO
GO:0001836release of cytochrome c from mitochondriaISO
GO:0002309T cell proliferation involved in immune responseISO
GO:0002326B cell lineage commitmentISO
GO:0002360T cell lineage commitmentISO
GO:0002687positive regulation of leukocyte migrationIMP
GO:0006289nucleotide-excision repairISO
GO:0006289nucleotide-excision repairISS
GO:0006302double-strand break repairISO
GO:0006351transcription, DNA-dependentIBA
GO:0006351transcription, DNA-dependentISO
GO:0006355regulation of transcription, DNA-dependentISO
GO:0006357regulation of transcription from RNA polymerase II promoterTAS
GO:0006461protein complex assemblyISO
GO:0006915apoptosisIEA
GO:0006915apoptosisISO
GO:0006915apoptosisISS
GO:0006917induction of apoptosisISO
GO:0006974response to DNA damage stimulusISO
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestISO
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIBA
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorISO
GO:0006979response to oxidative stressIEP
GO:0006983ER overload responseISO
GO:0007049cell cycleIEA
GO:0007050cell cycle arrestISO
GO:0007179transforming growth factor beta receptor signaling pathwayISO
GO:0007265Ras protein signal transductionISO
GO:0007275multicellular organismal developmentISO
GO:0007275multicellular organismal developmentISS
GO:0007369gastrulationISO
GO:0007406negative regulation of neuroblast proliferationISO
GO:0007417central nervous system developmentISO
GO:0007568agingIEP
GO:0007569cell agingISO
GO:0007569cell agingISS
GO:0008104protein localizationISO
GO:0008156negative regulation of DNA replicationISO
GO:0008285negative regulation of cell proliferationISO
GO:0008340determination of adult lifespanISO
GO:0008635activation of caspase activity by cytochrome cISO
GO:0008635activation of caspase activity by cytochrome cISS
GO:0009303rRNA transcriptionISO
GO:0009411response to UVIEP
GO:0009411response to UVISO
GO:0009651response to salt stressISO
GO:0009792embryo development ending in birth or egg hatchingISO
GO:0010035response to inorganic substanceIEP
GO:0010038response to metal ionIEP
GO:0010165response to X-rayIEP
GO:0010165response to X-rayISO
GO:0010243response to organic nitrogenIEP
GO:0010332response to gamma radiationIBA
GO:0010332response to gamma radiationISO
GO:0014070response to organic cyclic compoundIEP
GO:0030308negative regulation of cell growthISO
GO:0030308negative regulation of cell growthISS
GO:0030330DNA damage response, signal transduction by p53 class mediatorISO
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathwayISO
GO:0031000response to caffeineIEP
GO:0031065positive regulation of histone deacetylationIBA
GO:0031065positive regulation of histone deacetylationISO
GO:0031571mitotic cell cycle G1/S transition DNA damage checkpointIBA
GO:0031571mitotic cell cycle G1/S transition DNA damage checkpointISO
GO:0032526response to retinoic acidIEP
GO:0033077T cell differentiation in thymusISO
GO:0033552response to vitamin B3IEP
GO:0034097response to cytokine stimulusIEP
GO:0034613cellular protein localizationISO
GO:0034644cellular response to UVIBA
GO:0034644cellular response to UVISO
GO:0035264multicellular organism growthISO
GO:0035690cellular response to drugISO
GO:0042060wound healingIEP
GO:0042127regulation of cell proliferationISO
GO:0042149cellular response to glucose starvationISO
GO:0042221response to chemical stimulusIEP
GO:0042493response to drugIEP
GO:0042493response to drugISO
GO:0042771DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosisIBA
GO:0042771DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosisISO
GO:0042981regulation of apoptosisISO
GO:0043065positive regulation of apoptosisIMP
GO:0043065positive regulation of apoptosisISO
GO:0043066negative regulation of apoptosisISO
GO:0043200response to amino acid stimulusIEP
GO:0043523regulation of neuron apoptosisISO
GO:0043525positive regulation of neuron apoptosisIBA
GO:0043525positive regulation of neuron apoptosisISO
GO:0045787positive regulation of cell cycleIMP
GO:0045892negative regulation of transcription, DNA-dependentIDA
GO:0045892negative regulation of transcription, DNA-dependentISO
GO:0045893positive regulation of transcription, DNA-dependentISO
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterISO
GO:0046677response to antibioticISO
GO:0046902regulation of mitochondrial membrane permeabilityISO
GO:0048147negative regulation of fibroblast proliferationISO
GO:0048662negative regulation of smooth muscle cell proliferationIMP
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationISO
GO:0050790regulation of catalytic activityISO
GO:0051262protein tetramerizationIEA
GO:0051276chromosome organizationISO
GO:0051453regulation of intracellular pHIMP
GO:0051726regulation of cell cycleISO
GO:0055093response to hyperoxiaIEP
GO:0070245positive regulation of thymocyte apoptosisISO
GO:0071158positive regulation of cell cycle arrestISO
GO:0071417cellular response to organic nitrogenIEP
GO:0071456cellular response to hypoxiaISO
GO:0071479cellular response to ionizing radiationISO
GO:0072332signal transduction by p53 class mediator resulting in induction of apoptosisISO
GO:0090399replicative senescenceISO
GO:0090403oxidative stress-induced premature senescenceISO
GO:2000279negative regulation of DNA biosynthetic processIMP
GO:2000379positive regulation of reactive oxygen species metabolic processISO
cellular_component
GO:0000785chromatinIDA
GO:0000790nuclear chromatinISO
GO:0005625soluble fractionIDA
GO:0005626insoluble fractionISO
GO:0005634nucleusIDA
GO:0005634nucleusISO
GO:0005634nucleusISS
GO:0005654nucleoplasmISO
GO:0005657replication forkIBA
GO:0005657replication forkISO
GO:0005667transcription factor complexIDA
GO:0005669transcription factor TFIID complexISO
GO:0005730nucleolusISO
GO:0005730nucleolusISS
GO:0005737cytoplasmIDA
GO:0005737cytoplasmISO
GO:0005737cytoplasmISS
GO:0005739mitochondrionIDA
GO:0005739mitochondrionISO
GO:0005739mitochondrionISS
GO:0005783endoplasmic reticulumIEA
GO:0005829cytosolIDA
GO:0005829cytosolISO
GO:0016363nuclear matrixISO
GO:0016604nuclear bodyISO
GO:0016605PML bodyISO
GO:0043234protein complexISO
molecular_function
GO:0000739DNA strand annealing activityISO
GO:0000739DNA strand annealing activityISS
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionISO
GO:0001085RNA polymerase II transcription factor bindingISO
GO:0002020protease bindingISO
GO:0002039p53 bindingIBA
GO:0003677DNA bindingISO
GO:0003677DNA bindingISS
GO:0003682chromatin bindingIBA
GO:0003682chromatin bindingISO
GO:0003684damaged DNA bindingIBA
GO:0003690double-stranded DNA bindingIBA
GO:0003700sequence-specific DNA binding transcription factor activityIBA
GO:0003700sequence-specific DNA binding transcription factor activityISO
GO:0005507copper ion bindingISO
GO:0005507copper ion bindingISS
GO:0005515protein bindingIPI
GO:0005524ATP bindingISO
GO:0005524ATP bindingISS
GO:0008022protein C-terminus bindingIPI
GO:0008134transcription factor bindingISO
GO:0019899enzyme bindingISO
GO:0019901protein kinase bindingISO
GO:0031625ubiquitin protein ligase bindingIPI
GO:0031625ubiquitin protein ligase bindingISO
GO:0035033histone deacetylase regulator activityISO
GO:0035035histone acetyltransferase bindingISO
GO:0043565sequence-specific DNA bindingIDA
GO:0044212transcription regulatory region DNA bindingIEA
GO:0044212transcription regulatory region DNA bindingISO
GO:0046872metal ion bindingIEA
GO:0046982protein heterodimerization activityISO
GO:0047485protein N-terminus bindingISO
GO:0051087chaperone bindingISO
GO:0051721protein phosphatase 2A bindingISO
GO:0070215MDM2 bindingISO

Protein-protein interaction details for Tp53 (Rattus norvegicus)
(Information is obtained from BioGRID)
Interacting proteinExperimentTypePubMed ID
Hsp90aa1Affinity Capture-Westernphysical9488468
Hspa4Affinity Capture-Westernphysical9488468
Cyp27b1Affinity Capture-Westernphysical9488468
UbcAffinity Capture-Westernphysical22046440
Mdm2Affinity Capture-Westernphysical22046440