Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ABL1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID25
Official gene symbolABL1
Full namec-abl oncogene 1, receptor tyrosine kinase
Aliases,ABL,JTK7,bcr/abl,c-ABL,p150,v-abl,
Gene summary The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq]
LocationChromosome: 9   Locus: 9q34.1
Gene position133589268 - 133763062  Map Viewer
Gene orientationplus
Gene size173795 bp
Gene sequence
OMIM ID189980