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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for ABL1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000115 regulation of transcription involved in S phase of mitotic cell cycle TAS GO:0006298 mismatch repair TAS GO:0006355 regulation of transcription, DNA-dependent TAS GO:0006464 protein modification process NAS GO:0006975 DNA damage induced protein phosphorylation IDA GO:0007411 axon guidance TAS GO:0007596 blood coagulation TAS GO:0008630 DNA damage response, signal transduction resulting in induction of apoptosis TAS GO:0010506 regulation of autophagy TAS GO:0018108 peptidyl-tyrosine phosphorylation IDA GO:0030036 actin cytoskeleton organization ISS GO:0030100 regulation of endocytosis TAS GO:0030155 regulation of cell adhesion TAS GO:0042692 muscle cell differentiation TAS GO:0042770 signal transduction in response to DNA damage IDA GO:0043065 positive regulation of apoptosis IDA GO:0051149 positive regulation of muscle cell differentiation TAS GO:0051353 positive regulation of oxidoreductase activity IDA GO:0071901 negative regulation of protein serine/threonine kinase activity IDA GO:2000145 regulation of cell motility TAS GO:2000249 regulation of actin cytoskeleton reorganization TAS GO:2001020 regulation of response to DNA damage stimulus IDA cellular_component GO:0005634 nucleus IDA GO:0005634 nucleus NAS GO:0005634 nucleus TAS GO:0005730 nucleolus IDA GO:0005737 cytoplasm TAS GO:0005739 mitochondrion IEA GO:0005829 cytosol TAS GO:0015629 actin cytoskeleton TAS GO:0016020 membrane IEA GO:0031965 nuclear membrane IEA GO:0048471 perinuclear region of cytoplasm IDA molecular_function GO:0000166 nucleotide binding IEA GO:0000287 magnesium ion binding IDA GO:0003677 DNA binding NAS GO:0003785 actin monomer binding TAS GO:0004515 nicotinate-nucleotide adenylyltransferase activity TAS GO:0004713 protein tyrosine kinase activity IDA GO:0004715 non-membrane spanning protein tyrosine kinase activity IDA GO:0004872 receptor activity IEA GO:0005515 protein binding IPI GO:0005524 ATP binding IDA GO:0008022 protein C-terminus binding IPI GO:0016301 kinase activity IEA GO:0017124 SH3 domain binding IPI GO:0030145 manganese ion binding IDA GO:0051019 mitogen-activated protein kinase binding IPI GO:0070064 proline-rich region binding IPI

Protein-protein interaction details for ABL1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID ATM Two-hybrid physical 9168117 NTRK1 Two-hybrid physical 10708759 PTPN6 Affinity Capture-Western physical 8692915 RB1 Affinity Capture-Western physical 9071815 BRCA1 Affinity Capture-Western physical 12024016 BRCA1 Affinity Capture-Western physical 12024016 BCR Affinity Capture-Western physical 12543778 BCR Reconstituted Complex physical 1712671 ABL1 Protein-peptide physical 12654250 PIK3R1 Reconstituted Complex physical 8294442 RAD51 Affinity Capture-Western physical 10212258 ABI2 Affinity Capture-Western physical 12569093 BCAR1 Affinity Capture-Western physical 8810278 ATR Protein-peptide physical 10608806 ABL2 Reconstituted Complex physical 12569093 RAD51 Reconstituted Complex physical 10212258 ATM Affinity Capture-Western physical 10212258 CRKL Affinity Capture-Western physical 8978305 GRB10 Affinity Capture-Western physical 9747873 RAD51 Affinity Capture-Western physical 10212258 ABL2 Affinity Capture-Western physical 12569093 ATM Affinity Capture-Western physical 10212258 ABL2 Affinity Capture-Western physical 12569093 CREB1 Reconstituted Complex physical 7565761 CRKL Reconstituted Complex physical 8978305 CRKL Two-hybrid physical 8978305 CRKL Two-hybrid physical 7926767 CRKL Affinity Capture-Western physical 7926767 JAK1 Reconstituted Complex physical 9774693 RAD51 Affinity Capture-Western physical 10212258 YTHDC1 Biochemical Activity physical 15175272 YTHDC1 Affinity Capture-Western physical 15175272 GPX1 Affinity Capture-Western physical 12893824 GPX1 Affinity Capture-Western physical 12893824 GPX1 Reconstituted Complex physical 12893824 GPX1 Reconstituted Complex physical 12893824 CAT Affinity Capture-Western physical 12777400 CAT Affinity Capture-Western physical 12777400 CAT Reconstituted Complex physical 12777400 CAT Biochemical Activity physical 12777400 ABI1 Reconstituted Complex physical 12672821 ABI1 Affinity Capture-Western physical 9010225 TP53 Reconstituted Complex physical 10629029 CRKL Affinity Capture-Western physical 9820532 SHC1 Affinity Capture-Western physical 10194451 INPPL1 Affinity Capture-Western physical 10194451 SHC1 Affinity Capture-Western physical 8112292 BCR Affinity Capture-Western physical 8112292 BCR Reconstituted Complex physical 8112292 SOS1 Affinity Capture-Western physical 8112292 SLC9A2 Reconstituted Complex physical 10187839 PRKDC Reconstituted Complex physical 9312071 TP73 Reconstituted Complex physical 10391251 TP73 Affinity Capture-Western physical 10391251 DOK1 Reconstituted Complex physical 11071635 ST5 Reconstituted Complex physical 9632734 ZAP70 Affinity Capture-Western physical 7760813 TP73 Affinity Capture-Western physical 10391250 RB1 Reconstituted Complex physical 8242749 RFX1 Affinity Capture-Western physical 9583676 RFX1 Reconstituted Complex physical 9583676 RAD9A Affinity Capture-Western physical 11971963 RAD9A Affinity Capture-Western physical 11971963 RAD9A Reconstituted Complex physical 11971963 RAD9A Biochemical Activity physical 11971963 TERF1 Affinity Capture-Western physical 11375976 ATM Affinity Capture-Western physical 11375976 ATM Affinity Capture-Western physical 11375976 TERF1 Affinity Capture-Western physical 11375976 HCK Affinity Capture-Western physical 9407116 GRB2 Affinity Capture-Western physical 9407116 DOK1 Affinity Capture-Western physical 9008161 DOK1 Biochemical Activity physical 9008161 VAV1 Reconstituted Complex physical 11790798 VAV1 Two-hybrid physical 11790798 VAV1 Affinity Capture-Western physical 11790798 VAV1 Biochemical Activity physical 11790798 MDM2 Affinity Capture-Western physical 12110584 MDM2 Reconstituted Complex physical 12110584 MDM2 Biochemical Activity physical 12110584 MTOR Affinity Capture-Western physical 10753870 MTOR Affinity Capture-Western physical 10753870 ZDHHC16 Two-hybrid physical 12021275 ZDHHC16 Affinity Capture-Western physical 12021275 SPTA1 Reconstituted Complex physical 9593709 SPTAN1 Reconstituted Complex physical 9593709 SPTA1 Affinity Capture-Western physical 9593709 SPTAN1 Two-hybrid physical 9593709 ARHGAP17 Reconstituted Complex physical 11431473 ABI2 Reconstituted Complex physical 7590236 ABI2 Affinity Capture-Western physical 7590236 EVL Reconstituted Complex physical 10945997 PSTPIP1 Affinity Capture-Western physical 11163214 PSTPIP1 Reconstituted Complex physical 11163214 PSTPIP1 Two-hybrid physical 11163214 NEDD9 Affinity Capture-Western physical 8879209 CABLES2 Affinity Capture-Western physical 11955625 NTRK1 Affinity Capture-Western physical 10679771 NEDD9 Affinity Capture-Western physical 8668148 SORBS2 Reconstituted Complex physical 9211900 SORBS2 Biochemical Activity physical 9211900 SH3BP1 Reconstituted Complex physical 1379745 CBL Affinity Capture-Western physical 12475393 SORBS2 Affinity Capture-Western physical 12475393 TUB Biochemical Activity physical 10455176 GRB10 Reconstituted Complex physical 9006901 RYBP Two-hybrid physical 8943360 RYBP Far Western physical 8943360 RYBP Reconstituted Complex physical 8943360 PAK2 Affinity Capture-Western physical 11121037 PAK2 Biochemical Activity physical 11121037 PAG1 Two-hybrid physical 9334312 PAG1 Affinity Capture-Western physical 9334312 RAN Affinity Capture-Western physical 11420673 ATM Affinity Capture-Western physical 9168117 ATM Reconstituted Complex physical 9168117 CBL Biochemical Activity physical 11494134 NCK1 Affinity Capture-Western physical 11494134 CBL Affinity Capture-Western physical 11494134 CBL Far Western physical 11494134 NTRK1 Reconstituted Complex physical 10708759 PLCG1 Reconstituted Complex physical 10708759 BCAR1 Biochemical Activity physical 7780740 ABI1 Reconstituted Complex physical 11418237 MICAL1 Reconstituted Complex physical 11827972 XRCC6 Affinity Capture-Western physical 9798959 SORBS1 Affinity Capture-Western physical 11374898 SHD Two-hybrid physical 9315092 SHE Two-hybrid physical 9315092 SHD Biochemical Activity physical 9315092 NCK1 Reconstituted Complex physical 7926767 GRB2 Reconstituted Complex physical 7926767 CRKL Reconstituted Complex physical 7926767 NCK1 Two-hybrid physical 7926767 GRB2 Two-hybrid physical 7926767 EPHB2 Affinity Capture-Western physical 11494128 EPHB2 Reconstituted Complex physical 11494128 EPHA3 Reconstituted Complex physical 11494128 SRC Reconstituted Complex physical 11494128 EPHB2 Two-hybrid physical 11494128 NCOA3 Affinity Capture-Western physical 18765637 NCOA3 Reconstituted Complex physical 18765637 TOPBP1 Reconstituted Complex physical 15961388 TOPBP1 Affinity Capture-Western physical 15961388 TOPBP1 Affinity Capture-Western physical 15961388 TOPBP1 Biochemical Activity physical 15961388 HSP90AA1 Affinity Capture-Western physical 15937340 HSPA4 Affinity Capture-Western physical 15937340 NFKBIA Affinity Capture-Western physical 12167702 NFKBIA Reconstituted Complex physical 12167702 ATM Biochemical Activity physical 17409407 PARK2 Reconstituted Complex physical 20823226 PARK2 Affinity Capture-Western physical 20823226 PARK2 Affinity Capture-Western physical 20823226 STK4 Biochemical Activity physical 21715626 STK4 Affinity Capture-Western physical 21715626 ATR Affinity Capture-Western physical 20798688 ATM Affinity Capture-Western physical 20798688 ATR Biochemical Activity physical 20798688 PARK2 Biochemical Activity physical 20823226 UBC Affinity Capture-Western physical 21248063 HSP90AA1 Affinity Capture-Western physical 21248063 UBC Reconstituted Complex physical 20675402 STUB1 Biochemical Activity physical 20675402 CBL Biochemical Activity physical 20675402 BAG1 Reconstituted Complex physical 20675402 BAG1 Affinity Capture-Western physical 20675402 BAG1 Affinity Capture-Western physical 20675402 HSPA8 Reconstituted Complex physical 20675402 HSPA8 Affinity Capture-Western physical 20675402 HSP90AA1 Affinity Capture-Western physical 20675402 PARK2 Reconstituted Complex physical 21209200 PARK2 Reconstituted Complex physical 21209200 PARK2 Biochemical Activity physical 21209200 PARK2 Affinity Capture-Western physical 21209200 PARK2 Affinity Capture-Western physical 21209200