Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for GLI2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2736
Official gene symbolGLI2
Full nameGLI family zinc finger 2
Aliases,HPE9,THP1,THP2,
Gene summaryThis gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq]
LocationChromosome: 2   Locus: 2q14
Gene position121554867 - 121750229  Map Viewer
Gene orientationplus
Gene size195363 bp
Gene sequence
OMIM ID165230