Entrez gene ID | | 3091 |
Official gene symbol | | HIF1A |
Full name | | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
Aliases | | ,HIF-1alpha,HIF1,HIF1-ALPHA,MOP1,PASD8,bHLHe78, |
Gene summary | | Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq] |
Location | | Chromosome: 14 Locus: 14q21-q24 |
Gene position | | 62162119 - 62214977 Map Viewer |
Gene orientation | | plus |
Gene size | | 52859 bp |
Gene sequence |
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OMIM ID | | 603348 |