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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for HIF1A (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001525 angiogenesis IEA GO:0001666 response to hypoxia IDA GO:0001666 response to hypoxia IEA GO:0001666 response to hypoxia IMP GO:0001755 neural crest cell migration IEA GO:0001837 epithelial to mesenchymal transition IEA GO:0001837 epithelial to mesenchymal transition ISS GO:0001892 embryonic placenta development IEA GO:0001938 positive regulation of endothelial cell proliferation IC GO:0001947 heart looping IEA GO:0002248 connective tissue replacement involved in inflammatory response wound healing IEA GO:0002248 connective tissue replacement involved in inflammatory response wound healing ISS GO:0006089 lactate metabolic process IEA GO:0006351 transcription, DNA-dependent IDA GO:0006351 transcription, DNA-dependent TAS GO:0006355 regulation of transcription, DNA-dependent IDA GO:0006355 regulation of transcription, DNA-dependent TAS GO:0006879 cellular iron ion homeostasis IEA GO:0007165 signal transduction IMP GO:0009749 response to glucose stimulus IEA GO:0010468 regulation of gene expression IDA GO:0010573 vascular endothelial growth factor production IDA GO:0010575 positive regulation vascular endothelial growth factor production IDA GO:0010634 positive regulation of epithelial cell migration IEA GO:0010634 positive regulation of epithelial cell migration ISS GO:0010870 positive regulation of receptor biosynthetic process IMP GO:0014850 response to muscle activity IEA GO:0030154 cell differentiation IEA GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IC GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IEA GO:0032364 oxygen homeostasis IDA GO:0032722 positive regulation of chemokine production TAS GO:0032869 cellular response to insulin stimulus IEA GO:0032909 regulation of transforming growth factor beta2 production IMP GO:0032963 collagen metabolic process IEA GO:0032963 collagen metabolic process ISS GO:0035162 embryonic hemopoiesis IEA GO:0042541 hemoglobin biosynthetic process IEA GO:0042593 glucose homeostasis IEA GO:0042789 mRNA transcription from RNA polymerase II promoter IC GO:0042981 regulation of apoptosis IEA GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress IDA GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress IEA GO:0045648 positive regulation of erythrocyte differentiation IC GO:0045648 positive regulation of erythrocyte differentiation IEA GO:0045766 positive regulation of angiogenesis IC GO:0045821 positive regulation of glycolysis IC GO:0045893 positive regulation of transcription, DNA-dependent IDA GO:0045926 negative regulation of growth IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IGI GO:0046716 muscle cell homeostasis IEA GO:0046886 positive regulation of hormone biosynthetic process IDA GO:0048661 positive regulation of smooth muscle cell proliferation IEA GO:0050790 regulation of catalytic activity IEA GO:0051000 positive regulation of nitric-oxide synthase activity TAS GO:0051216 cartilage development IEA GO:0051541 elastin metabolic process IEA GO:0051541 elastin metabolic process ISS GO:0070101 positive regulation of chemokine-mediated signaling pathway IC GO:0071347 cellular response to interleukin-1 IEP GO:0071456 cellular response to hypoxia IEP cellular_component GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005667 transcription factor complex IPI GO:0005730 nucleolus IDA GO:0005737 cytoplasm IDA GO:0005737 cytoplasm IEA GO:0009434 microtubule-based flagellum IEA molecular_function GO:0003677 DNA binding IEA GO:0003700 sequence-specific DNA binding transcription factor activity IDA GO:0003700 sequence-specific DNA binding transcription factor activity IEA GO:0003700 sequence-specific DNA binding transcription factor activity TAS GO:0003705 sequence-specific distal enhancer binding RNA polymerase II transcription factor activity IDA GO:0004871 signal transducer activity IEA GO:0005515 protein binding IPI GO:0008134 transcription factor binding IPI GO:0035035 histone acetyltransferase binding IPI GO:0042826 histone deacetylase binding IEA GO:0043565 sequence-specific DNA binding IDA GO:0043565 sequence-specific DNA binding IEA GO:0044212 transcription regulatory region DNA binding IDA GO:0046982 protein heterodimerization activity IEA GO:0046982 protein heterodimerization activity IPI GO:0046982 protein heterodimerization activity TAS GO:0051879 Hsp90 protein binding IDA

Protein-protein interaction details for HIF1A (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID SSX4 Two-hybrid physical 16189514 VHL Affinity Capture-Western physical 14556007 PSMC3 Affinity Capture-Western physical 14556007 ZNF197 Affinity Capture-Western physical 12682018 VHL Affinity Capture-Western physical 12682018 MDM2 Reconstituted Complex physical 12606552 MDM2 Affinity Capture-Western physical 12606552 TP53 Affinity Capture-Western physical 12606552 HIF1AN Affinity Capture-Western physical 11641274 HIF1AN Reconstituted Complex physical 11641274 HIF1AN Reconstituted Complex physical 11641274 VHL Reconstituted Complex physical 11641274 HDAC1 Reconstituted Complex physical 11641274 HDAC2 Reconstituted Complex physical 11641274 HDAC3 Reconstituted Complex physical 11641274 EP300 Affinity Capture-Western physical 11823643 EP300 Co-crystal Structure physical 11959990 CREBBP Two-hybrid physical 10202154 CREBBP Reconstituted Complex physical 10202154 CREBBP Reconstituted Complex physical 9887100 PSMA7 Reconstituted Complex physical 11389899 PSMA7 Affinity Capture-Western physical 11389899 DAP3 Reconstituted Complex physical 10903152 NCOA1 Reconstituted Complex physical 10594042 APEX1 Reconstituted Complex physical 10594042 JUN Affinity Capture-Western physical 11739718 ARNT Affinity Capture-Western physical 11782478 VHL Reconstituted Complex physical 10944113 TP53 Affinity Capture-Western physical 10640274 MDM2 Biochemical Activity physical 10640274 TP53 Reconstituted Complex physical 12124396 ARNT Two-hybrid physical 9079689 HSP90AA1 Reconstituted Complex physical 9079689 ARNT Reconstituted Complex physical 9079689 TP53 Affinity Capture-Western physical 9537326 TP53 Affinity Capture-Western physical 9537326 VHL Co-crystal Structure physical 12004076 VHL Reconstituted Complex physical 11504942 VHL Affinity Capture-Western physical 11504942 ARNTL Two-hybrid physical 9576906 ARNTL Reconstituted Complex physical 9576906 STAT3 Affinity Capture-Western physical 18985005 STAT3 Affinity Capture-Western physical 18985005 VHL Affinity Capture-Western physical 18985005 VHL Affinity Capture-Western physical 18985005 UBC Affinity Capture-Western physical 18694926 VHL Affinity Capture-Western physical 18694926 UBC Affinity Capture-Western physical 18426857 VHL Reconstituted Complex physical 18426857 CREBBP Affinity Capture-Western physical 18426857 NR4A1 Affinity Capture-Western physical 18305400 UBC Affinity Capture-Western physical 18305400 VHL Reconstituted Complex physical 18305400 NR4A1 Affinity Capture-Western physical 18305400 VHL Affinity Capture-Western physical 17981124 VHL Reconstituted Complex physical 17981124 UBC Affinity Capture-Western physical 17973296 VHL Affinity Capture-Western physical 17973296 SAT1 Reconstituted Complex physical 17875644 GNB2L1 Reconstituted Complex physical 17875644 UBC Affinity Capture-Western physical 17875644 MTA1 Affinity Capture-Western physical 16511565 MTA1 Affinity Capture-Western physical 16511565 HDAC1 Affinity Capture-Western physical 16511565 NAA10 Affinity Capture-Western physical 16511565 NAA10 Reconstituted Complex physical 16511565 MTA1 Reconstituted Complex physical 16511565 SAT2 Reconstituted Complex physical 17558023 SAT2 Affinity Capture-Western physical 17558023 VHL Reconstituted Complex physical 17558023 VHL Reconstituted Complex physical 17558023 VHL Affinity Capture-Western physical 17558023 TCEB1 Affinity Capture-Western physical 17558023 UBC Affinity Capture-Western physical 17558023 CUL2 Affinity Capture-Western physical 17439941 UBC Affinity Capture-Western physical 17403672 VHL Affinity Capture-Western physical 17047048 UBC Affinity Capture-Western physical 16611863 VHL Affinity Capture-Western physical 16611863 CREBBP Affinity Capture-Western physical 16579968 HSPA4 Affinity Capture-Western physical 16507982 SEPT9 Affinity Capture-Western physical 16424018 SEPT9 Affinity Capture-Western physical 16424018 UBC Affinity Capture-Western physical 16424018 EGLN1 Reconstituted Complex physical 16407130 ARNT Affinity Capture-MS physical 20562859 BANP Affinity Capture-MS physical 20562859 NAA10 Affinity Capture-Western physical 16288748 NAA10 Reconstituted Complex physical 16288748 VHL Affinity Capture-Western physical 16278378 HDAC4 Affinity Capture-Western physical 19071119 HDAC5 Affinity Capture-Western physical 19071119 HDAC4 Reconstituted Complex physical 19071119 HDAC5 Reconstituted Complex physical 19071119 VHL Affinity Capture-Western physical 15805242 USP20 Affinity Capture-Western physical 15776016 USP20 Affinity Capture-Western physical 15776016 USP20 Biochemical Activity physical 15776016 UBC Affinity Capture-Western physical 15776016 OS9 Two-hybrid physical 15721254 OS9 Reconstituted Complex physical 15721254 OS9 Affinity Capture-Western physical 15721254 EGLN1 Reconstituted Complex physical 15721254 EGLN3 Reconstituted Complex physical 15721254 VHL Reconstituted Complex physical 15721254 MTA1 Affinity Capture-Western physical 16969516 MTA1 Reconstituted Complex physical 16969516 HSP90AA1 Affinity Capture-Western physical 16951198 HSPA4 Affinity Capture-Western physical 16951198 HDAC6 Affinity Capture-Western physical 16951198 HDAC4 Affinity Capture-Western physical 16951198 SUMO1 Affinity Capture-Western physical 15465032 SUMO1 Affinity Capture-Western physical 15465032 UBC Affinity Capture-Western physical 15382039 UBC Affinity Capture-Western physical 15382039 HSPA4 Affinity Capture-Western physical 16507982 HSP90AA1 Affinity Capture-Western physical 16507982 HSP90AA1 Affinity Capture-Western physical 15147973 VHLL Reconstituted Complex physical 14757845 VHLL Affinity Capture-Western physical 14757845 HSPA4 Affinity Capture-Western physical 14726529 HSP90AA1 Affinity Capture-Western physical 14726529 HSPA4 Reconstituted Complex physical 14726529 SHC1 Affinity Capture-Western physical 12114320 UBC Affinity Capture-Western physical 12114320 VHL Co-crystal Structure physical 12050673 VHL Reconstituted Complex physical 12050673 VHL Affinity Capture-Western physical 14691445 EP300 Affinity Capture-Western physical 14691445 VHL Affinity Capture-Western physical 14600153 VHL Affinity Capture-Western physical 12925778 VHL Protein-peptide physical 12925778 VHL Affinity Capture-Western physical 12808024 VHL Reconstituted Complex physical 12606543 VHL Reconstituted Complex physical 12538644 VHL Affinity Capture-Western physical 12464182 PARP1 Affinity Capture-Western physical 18314489 EGLN2 Reconstituted Complex physical 18264140 EGLN1 Reconstituted Complex physical 18264140 EGLN3 Reconstituted Complex physical 18264140 VHL Reconstituted Complex physical 18264140 ARNT Co-localization physical 15347669 SMARCA2 Co-localization physical 15347669 SMARCA4 Co-localization physical 15347669 CREBBP Co-crystal Structure physical 15154850 EP300 Reconstituted Complex physical 15154850 MYC Affinity Capture-Western physical 15071503 MYC Affinity Capture-Western physical 15071503 EP300 Affinity Capture-Western physical 11940656 VHL Affinity Capture-Western physical 11865071 MAX Affinity Capture-Western physical 17418410 VHL Protein-peptide physical 11566883 VHL Biochemical Activity physical 11566883 VHL Affinity Capture-Western physical 11331613 VHL Affinity Capture-Western physical 11292861 VHL Reconstituted Complex physical 11292861 VHL Biochemical Activity physical 10973499 VHL Affinity Capture-Western physical 10973499 VHL Affinity Capture-Western physical 10973499 VHL Reconstituted Complex physical 10878807 VHL Reconstituted Complex physical 10878807 VHL Affinity Capture-Western physical 10823831 VHL Reconstituted Complex physical 10823831 UBC Affinity Capture-Western physical 10758161 HDAC1 Affinity Capture-Western physical 17273746 HDAC3 Affinity Capture-Western physical 17273746 HDAC1 Reconstituted Complex physical 17273746 HDAC3 Reconstituted Complex physical 17273746 RUVBL2 Affinity Capture-Western physical 20603076 MCM7 Affinity Capture-Western physical 21658608 MCM7 Reconstituted Complex physical 21658608 MCM3 Affinity Capture-Western physical 21658608 MCM3 Affinity Capture-Western physical 21658608 TCEB1 Affinity Capture-Western physical 21658608 UBC Affinity Capture-Western physical 21658608 UBC Affinity Capture-Western physical 17965024 TCEB1 Affinity Capture-Western physical 17965024 HSP90AB1 Affinity Capture-Western physical 19802386 COMMD1 Affinity Capture-Western physical 19802386 HSPA4 Affinity Capture-Western physical 19802386 COMMD1 Affinity Capture-Western physical 19802386 CUL2 Affinity Capture-Western physical 17132228 VHL Affinity Capture-Western physical 17132228 HSP90AA1 Affinity Capture-Western physical 17237281 UBC Affinity Capture-Western physical 17237281 ARNT Affinity Capture-Western physical 21435239 UBC Affinity Capture-Western physical 21332579 VHL Affinity Capture-Western physical 21332579 ARNT Affinity Capture-Western physical 20049704 ARNT Affinity Capture-Western physical 20049704 VHL Affinity Capture-Western physical 20049704 UBC Affinity Capture-Western physical 20407014 UBC Affinity Capture-Western physical 20724477 EGLN1 Affinity Capture-Western physical 20724477 VHL Affinity Capture-Western physical 20724477 HSP90AA1 Affinity Capture-Western physical 20724477 HSP90AA1 Affinity Capture-Western physical 20724477 VHL Biochemical Activity physical 15060148 NSFL1C Affinity Capture-Western physical 18775313 FAF2 Affinity Capture-Western physical 18775313 FAF1 Affinity Capture-Western physical 18775313 UBXN7 Affinity Capture-Western physical 18775313 UBXN1 Affinity Capture-Western physical 18775313 VCP Affinity Capture-Western physical 18775313 JUN Affinity Capture-Western physical 19738058 JUN Affinity Capture-Western physical 19738058 UBC Affinity Capture-Western physical 19738058 HSPA4 Affinity Capture-MS physical 19940151 STUB1 Affinity Capture-MS physical 19940151 VHL Affinity Capture-MS physical 19940151 TCEB1 Affinity Capture-MS physical 19940151 TCEB2 Affinity Capture-MS physical 19940151 CUL2 Affinity Capture-MS physical 19940151 HIF1AN Affinity Capture-MS physical 19940151 EP300 Affinity Capture-MS physical 19940151 HSPA4 Affinity Capture-Western physical 19940151 STUB1 Affinity Capture-Western physical 19940151 STUB1 Affinity Capture-Western physical 19940151 HSPA4 Reconstituted Complex physical 19940151 STUB1 Reconstituted Complex physical 19940151 UBC Affinity Capture-Western physical 19940151 UBC Affinity Capture-Western physical 19940151 HSP90AA1 Affinity Capture-Western physical 21413014 FBXW7 Affinity Capture-Western physical 21964756 SUMO1 Affinity Capture-Western physical 20026589 SUMO2 Affinity Capture-Western physical 20026589 SP1 Affinity Capture-Western physical 17024177 SP1 Reconstituted Complex physical 17024177 UBC Affinity Capture-Western physical 21964756 UBC Affinity Capture-Western physical 21335603 VHL Reconstituted Complex physical 21335603 EP300 Reconstituted Complex physical 12778114 UBC Affinity Capture-MS physical 18781797 UBC Affinity Capture-MS physical 21987572 VHL Reconstituted Complex physical 21358672