Entrez gene ID | | 3553 |
Official gene symbol | | IL1B |
Full name | | interleukin 1, beta |
Aliases | | ,IL-1,IL1-BETA,IL1F2, |
Gene summary | | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq] |
Location | | Chromosome: 2 Locus: 2q14 |
Gene position | | 113594356 - 113587337 Map Viewer |
Gene orientation | | minus |
Gene size | | 7020 bp |
Gene sequence |
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OMIM ID | | 147720 |
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