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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for IL4 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 3565 Official gene symbol IL4 Full name interleukin 4 Aliases ,BCGF-1,BCGF1,BSF1,IL-4,MGC79402, Gene summary The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq] Location Chromosome: 5   Locus: 5q31.1 Gene position 132009373 - 132018368  Map Viewer Gene orientation plus Gene size 8996 bp Gene sequence >IL4:40323245..40332240:Length=8996 TTCTATGCAAAGCAAAAAGCCAGCAGCAGCCCCAAGCTGATAAGATTAATCTAAAGAGCA AATTATGGTGTAATTTCCTATGCTGAAACTTTGTAGTTAATTTTTTAAAAAGGTTTCATT TTCCTATTGGTCTGATTTCACAGGAACATTTTACCTGTTTGTGAGGCATTTTTTCTCCTG GAAGAGAGGTGCTGATTGGCCCCAAGTGACTGACAATCTGGTGTAACGAAAATTTCCAAT GTAAACTCATTTTCCCTCGGTTTCAGCAATTTTAAATCTATATATAGAGATATCTTTGTC AGCATTGCATCGTTAGCTTCTCCTGATAAACTAATTGCCTCACATTGTCACTGCAAATCG ACACCTATTAATGGGTCTCACCTCCCAACTGCTTCCCCCTCTGTTCTTCCTGCTAGCATG TGCCGGCAACTTTGTCCACGGACACAAGTGCGATATCACCTTACAGGAGATCATCAAAAC TTTGAACAGCCTCACAGAGCAGAAGGTGAGTACCTATCTGGCACCATCTCTCCAGATGTT CTGGTGATGCTCTCAGTATTTCTAGGCATGAAAACGTTAACAGCTGCTAGAGAAGTTGGA ACTGGTGGTTGGTGGCAGTCCAGGGCACACAGCGAGGCTTCTCCCCTGCCACTCTTTTTT CTGAGGGTTTGTAGGAAGTTTCCTCAGTTGGAGGGAGTGAGAGCTGCTCATCAAGGACTT CTCTGTCCGGTTGGAGGTTAACTCTGTCTCTTGCTCTCTCATTTCTGCCTGGACCAAGAC TCTGTGCACCGAGTTGACCGTAACAGACATCTTTGCTGCCTCCAAGGTAAGAAGCCGTCC CACGGTCTGTTTTAGCAAATGGGGAGATCCATCCCCAAATGTCTGAACAAGAAACTTGTC TAATGGAAAACGAGCGGGCCCAAATTAACTCTAAGGTGTTAGATGTTTTCAAAGAACGAG AAGTCTGATCTTTACTCTTAAGCATGTTTTGGTCTTTCTGGTTTCACTTGATTTAGAAGA CATGTAATAGAAAGCTTACATGCTGTAGTCCTGACTCAGATCCTGGTCAAAGAAAAGCCC TCTTGGGTTTTACTTAGCTTTGGCATAGTGCCTGGAACGTAGGAGGCACTCAATAAATGC CTGTTGAATGAGAGAATTTTTCTGGCCCATACATTTCTGAAAAACCAAATACTCTCACAG AAACAGATATTGAGATGACAGGTTGAGGGAGCTTTCATTTTGTCTAAGAGACTTCCTATG GCAACAGAAAAGGTATCGCCAGAGCCCCTCCTCTTCCACAGCCTGGCCACCTAACAGCCC TCTGGGTTCCGGGGCTGGCCGTCCAGAGCTCCTCAGCTTGCTCTGGCCGGCCGAACTCCC CTCCAGCTCGGTCTGGAACCATCCTGCTGGGCAGCGTCCAGCACATCCCTGCTTCGGGCT GCCTGGGCACCTCGCCTCTCTGCCTCCTGTGCTGCCTCACCCCCACCCCTCTATCTGTAG TGGGAGGAGATAGATTTGACAGCTGATAGTGCATTTTCTCTGACAAACACATGACTACAG CCGTATCAATAGTTTTGTGCATTTCAGTTCCTGTTTTCATGGAAACACACGGCTGAGAAT GAAAGCCCCAAAGCCTCAATTTCACAGTGGTCTCCTAACTACCTGCTTTCCATGCAAACT AGGGAGATGATATGGCCAGGAGTGAAGCCCTGTGTGTTGGGCAGGGTCACACTCCAGCAC CCAGACCATAGAACAGGGCCCATCCTGCTTCATGAGGGAAACTGCTCTTCGGGCCTTTAG CTGGACTATCTCATTTCATTAGTTATCCCGGGAGTCCGATACAGGATGAGATTCTGAAGG GCAAATACACACTTTTTTTTTTTTTTGAGATAGGGTCTTGTTCTGTCACCCAGGCTGGAG TGCAGTGGTGCGATTTCAGCTCATAGCAGCCTCCACCTCCCAGGCTCAAGCTATCTTCCT ACCTCAGCCTCCCAAGTAGCCGGGACGACAGGTGTGCACCACCACGCCTGGCTAATTTTT GTATTTTTTTGTAGAGATGGAGTCTTGCCATTTTGCCCAGGCTTGTCTCGAACTTCTGGG CTCAAGCAATCCGTCCACCTCGGCCTCTCAAAGTGCTGGGATTAGCCACTGCACCTGGGC AACAGTTTATGTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTGTGTATATAT ATGTGTGTATGTATATATGTGTATGTATATGTGTGTGTGTGTGTGTGTGTGTGTGTATAA AATCTCCAAGTCCATCCAACCGAGATGGCTCCTACTAGAAGCCAAGAGTCCACCGGGTTG AGCACTGGGTCTCTGGAGGCCTGTGGCACTGCTGAGAAGGCTCTAACAAAGCCAAGGGAA GGGCCACCTCACTAGAAGCCAGGCCTGGAGGAAGGGTGAGGGCTGAGGGCCTGGAGGTAA GACTGCCTGTGGTTTTAGACCCAGCTCTGCCACTGACTAGCTGTGTGGCTGGCCTTCAGC ACATCTTCACACCTCTCTGCACCTCAGTTTCCACATGTGAAGATATGAAAGTGATTCTGA AGGTGATTGCAAGGTTGATTGGAATCCAGCTCTTGAGTTAGTGCAAAGTGTTATTGTGAG ATGATATAACCACGATTAAAAGCAAGAACAGGTGCAGAGAAGCGATGATTCTAAGAAGGA GGGGACCGGGTTGGAAAGGATCAAACCATCCAGGATGCCGAGTCTGGGGCAATCCATCTG GGCTGTTTCTGGAAGACCCCCGGGTGCAGGCCAGGACACTGCTGCCCTCCCGTCCTTAAC TCCCCTCTTCACTCAGTCCTCACTCACCTCCCTCTCACACACACAAACATCTCCTAGAAT AATCCCCACTGCCTGCCTTCACTCTTACCCGTCTCATTTGCCTCCCCTGAACTTCATCCT CCTGGAGTTCACGATCTCACTCTTCACTCTTTTCTTCCCCTCGAAGATTCAGCACTGCTT ACTTACATGTTAAGATATTTCAGAACAGTGAAATGTTGCTATTTTCAAAAACCTACAAAG GTGGTATGCAGAGGAAAAGGTACTTCTTTGTGTTCCCAAAGAAAACATCTTTCCAAAATC CAGCCTATTGATTTTATTTCTTCGGGGGAACAAGAATTTTAGTATCTCTAAGTTGGGTAG CATTCTACTCTTGGCAGTTGCTGGAAAGAAGGCACTGGTCTAGGTCCTGGGCTTCACAGG TAACACCTGTCAGGGTGTCTATGAAGTCAAGGCTGTCTGAGGAACAGCAAAGTGGGAAGA AGCAAGCTGGCTGGCTGATGAAGGGTTTCTTGGGTGGACAAGTAGTTGGAGCTATTTCCT ATTTACCAAAGAGAGCTAAAGTTCATAATTCTACAGAGAGTTCCATAATGAACCTCAAAT ACCTCTGTTTTTTGAAGGAGTTTCTCATATACAGCACTAGCTGACTATCCTGGGCAGGAT GGGAGATAATGAATGCAGTGCCAATCGGGCTGGATTTATATGGTCCTCAGTGAGGCTGGT CAAGAACCGAGTTAGAACTCTCACAGAGTCACTGCCACAGAAGAAATCTCCCAAGTGGCT GTTTCCTGACATTCCCGGGAGGGACAGGCCTCCTTCTGAGTCACTCCCTAAGCAGTTCTG AACTGTGAGGTCAGCCAGGCTGTCCAAGTGCACTCCCTGAGCCACTGGCAGACACACTCA GCAGCCAGAGCTAGACAGGCAGGTGGTAGGAGTCCAGGGCCACGGCAGGGATGGAGTGTC GCCCCCTCGCTGCGATACCAGAGCAACTAAAACGTTAAGGCCTTGCACTAAAGCTGCCCT TAGGATGCATTCTTTTAAAGTTTTTCCATTTAATGCAGACTCTTTTCAATTCTTATTTTA TCCTTGTTTCCTTTAGAAAGTCCTTTCAAAAATATCTTTAGAGGGTTTTTTCCTATACTA TGTGGCCATATACGGGTCAAAATTAAGTTTAATTTCCAGGCTCCAAGCCAGCGTTTCAGA AAAATCTCACCAAGGTTTGTGGTAAAAGAAGCAAAGGGCTGACTTTTTGGTTTTCTTGAA TCTCACTGTTCCCTCTGCAGCAGCATGCATGTCTGCCCACCTCCAGACACACAGGCACCA TCTGCCGCCCCCCATCAGCCCGTGTCCCTTCCACCTCGACTCGCCTACAAAGCCCAGAGA GGTCTGTTTCTTGGCCCCCAGAGCCCAAAGATACTGACACACTCTTACATTTCCAACTAG AATCAGGAACGAGGAGTGACTCTCAGTCAGTTCATTAAGTAAATGTCTTTCTAACCGCTC TGCCCATGGGACATCACGCCCCACAGGGGAAAGGGGAAGCTTCTGTAGCCTGGGATTCTG GTGCCTCAGTCTGGGTCTAGACTTTCCTGAAAAAACGTTAAAATATGAACTGCATTCCTA GAATTTAGCCTACATAAATAAGAGATGAACACAAAGATTTCTATAGTTTACTCACTGCCG CTTATTTACAGAAGCAAAAATCTGCCACGATAGGGGCCTGACAAATGACAGTACCACTGT GCAATGCGTTTCTACGCAGCTCTCAATCCCATGTTCTCTAATACCACCGAAGGGCTTAGG AAATGCTTATGGTATATGTAAAGAGTAAAGAAGTTACAAAACAGTATCAACAGTTGACCC CTATTTTAAAAAGTATTTTTAAAAGTGTGACGATATTTACCAAAATATTAACAGCAATAG TTACCTCTGGCTGGTGGGATGAGTGAATGTATTTTTGTTGAATATATGTTACCTTTATAG TAAATATATGTTATCTTGATCATCAGAAAAAAAAATATGTAAGAACTTGAAAGCTGCTTG GACAGCGCTGCTGATAGAAACCCCTGAGCATCTTGTCACTGTTCTTCTGATTCAGAGGGT CTGGGTGGGGCAGGGGTGGTCTGAGATTCTGTATTTCTAAGAAGCTCCCAGTGATGTCCA TGCTGCTGGTCCATGGACCACACTTTGAGTATCAAGGGACCAGAGCATGTCGGGGGAGAG GCTGGGGATAGCTTTCTTTATCTGAACTGGATAAAGGAACTGGGCTCAAGCTAAGAACCC TCTCCAGGTTCTGCATCTTTGTTCTTCAGTGAAAAATGAGAGGACACACCAGGCCAGGTT CAGACTGAGACACAATCCCTCTCCTGGGTTCCCAATGACTTGTCTCTTGTCCATTCCCTT CTCTAAGGCTAAGGGCCCCCAGGAAGAGCCATGTGGCCAGACCCTCACAGTTGCTGGCAT TCCAAGGAGATTCTCACTCCGCATCATTTGGGGCCAAAAGGCCCCTTACAGAAGCTCTGC CCAAGGCTCAGATCAATGGCACCTGCTCCCAGAGCCTCCTCTGATCTCCCAGGACACCTT TCCCTGATCTGTGCACTTATCTCTTGCTGCCTGGCAAAATGTCTTAGCTCCTCACTTGGG CCATGTGCTGCTCTCCTCTCCCATGGGGAGAGCCACACGGAGAGTGCTGGCCAAAGCAGC AGAGTTCAGGCCAAAGGATGTGCACTCATTTATTCAACAGGCATGCAGGATTTCCAGGGA AAGCTGGATTTTAAAACCTCTGGGAACAAGAGCAGAACCTGACTGAGAGCTCATGTGGGC ACTTTTCATAGCAGAATAGCTCATGAGGTATAGAGACACGGACGCAGAACGTGGGCTGTA GCGACAGATGGTCCTGCATTCTAGTCCCCACTGTGCCTTTTCCTCATGGGATGACTTTAT TCAGGTACCCTTTCGGCAAAATCCTCCAAGAGAAAGGAAACTGGGAGGTTCTGGGGAGAA GGCTGCTGCGTTTGCAATTGGGAGAGGTTGTTGACAGAGGTTTATGTCTGTGGCAAGCAG CCTTCCTTCAGTGGAATACTTGAAGACAGGTCTGTAGTTGAGCAAACTCACCTCCATTTG TCCTCCTGGAAAGAAGAAATCAAGAGGAAAAATCTCTCTCCCATCCTCCAAATGGAGCTG GCACATTGCTATCTGTGGCATTTGTCTTTCCAGAACACAACTGAGAAGGAAACCTTCTGC AGGGCTGCGACTGTGCTCCGGCAGTTCTACAGCCACCATGAGAAGGACACTCGCTGCCTG GGTGCGACTGCACAGCAGTTCCACAGGCACAAGCAGCTGATCCGATTCCTGAAACGGCTC GACAGGAACCTCTGGGGCCTGGCGGGCTTGGTAAGCTGCACTGTATTCCTGGCAAGCCGG CCGCGTGGCTCCTGGTGGACAGCAGCCTCACTTCTAAACACTCCTTAGGAGCTGCAGCAC CCTTGGTCAACCCATTCATTCATTCACTCATTCAATAAGTATTTGCTGAAGTTCCACAAG TGCTGGGTGTGGTTCTAGGTGCTGAGGACGTGTCACTAAAGACACGCAGGCCGAGTCCCT GTTCTCATGGAATGTTCTAATGGGAGAGTTAGAAAAACAAACATGTAAAATGATGGCCAG CAGTGATACGTGCTACAAAGAAAAACATAGAAATAAAGAACATAAGAGTCATGGGGGAGG GGGCTGACTTAGGAGCTGGTGACATTATCTGAGCAGATATTTGAATTGAGGGAGCAGGCC ACATGACTAACTAGGGAGACCATTCCAGGCAGAAGGAGGAGGTATGCAAAGGCCTTAGGA TGGAAATGAACTAACTTCCTGTATTTAAAGACCAGTAGGAAGGCCAGTGTGGCTGGATCA GAGTGAGTGAGGGGTAGTTTCCAGGACAGCAGATCACACAAGGCCTTTAGATTCCACCAC GAGTATGGCAGGGAACACCTGCAGAGCTTTGGGCAGGACAAAGACTGTACAATCTGATTT ACGTGATTTAAAAGGGTCAGTCTGGCTACTGTGTGGTAAATAGGCTGAAAGGGGGAAAGC ATAGAAGCAAGATGGCCTGTTGGGAGGCTACCACAGTAAACCAGGCTAGAGATGATGGTG GCGTGGACAGAATGAAGCAAGATGGCCTGTTGGGAGGCTACCACAGTAAACCAGGCTAGA GACGATGGTGGCGTGGACAGAATGAAGCAAGATGGCCTGTTGGGAGGCTACCACAGTAAA CCAGGCTAGAGATGATGGTGGCGTGGACAGAATGGGAGCAGTTGAGGTGAACAGATTTGG GATATGACTAAAAATAAAACCAGAAGGATTTGCTGACAGATCGGTTGTAGGGGGTAAGAT ACAGGGGAGGAAAAGATGACCTCTTTGTTCCTGCCCAAACCCCTCTGGCGATGGTCAGTA CTGTTTACAGAGAGATGAAAGACTGGCGGCAAGGCAGGGCTGGAGGTTCAGCAGAAGATC AAGAGTTCAATTTTGTACATCGTACATGTAAGGTGGCTCTTGGATAGCCAAGTGAAGGTG TTGAGAAGATGGTTAGAAAAGTCTGGAACTTAGGGGAGAGGTCAGAACTTGCAATACAAA AAGGAGAGTCCTTAGATAGATACTGCTGAAAATCTGAATGACAGAAAGGGAGAGATCAAA GGACTGAGCCTGAGATCAACACATGGAGGTCAGGAGAGGAGGATCCAGCCAAGGGGCCTG AGGAGGAGTGACCAGTGAGGCAGGAGAACACTGGAGAGTGGGCGGTACCCCAGGAAGCCG TTGAGGACACTCAAGGAGGGAGGGTTGACTGTGTCAAATGTACTGAAAGGACAGGTCAGG TGAGGACCAAGAAAGGCCCCTGGGTTTGGCTGATGGAGGCCATGGGTGAGGCTGATGTAA ATGGAGAGGCAGGAAGGAAAGCCCAGCTGGAGTGGGCTCACCGAGGATAGGGTGGCGAGA GGAGACAAAGAAGGAACAGTGAGGGCAGAACACTCTTTGAAGATGTTTAGCTATAAGGCT GCAGAGAAACTGACCCACAGCTGCAGGGTGGTTATGGAGTGAGGGAAGCTCTTTTAAGGT TGGGGGTATACCCAGCATGTTAATGCACCTGGGGGAATGGTCCAGTGGAGCAGGAAGAAC TGAAGAGAGCAGAAAGAGGAAGAATCATTAGGGGGCAGAAGTCCTTGTAGCCCAGAGTGG ATGTTATCTAATATCGAGTGGAGGAATTAATTGGCTTTAGAGGAGAACAAGGACATGTAT CCCCTCTCTGGGCCTATCACCTTGTAGACAATGGGATAGGTCATGGGATAGGAACTTGGC ACAACACATGTTCTCTCTTTTAATTCTCTCCATTATCTTATGAAGCAGGCAAGTAGGCAA ACAATTGTCCCAACTTTACAAAAGAAACTGAAGCTTTTATAAATTAAGTAGTACATCCTA AGCAATACAATTAATAAATGGTAGAGCTGAGATTCAAACTGAAGCAGTGGCCTGGGGGTA GCATCTGGAATCCTTCCCACCTTTAGGGCTGCTGTGCTGCGGTGCTGCTGTTTAATGGCA CAGGAGGGCCACATGACTGAATCTCTCTCAGCAGTCCAGGCAGTCATGCAGAAGGCCCAG TAGAGCACCGGGCAGGTCTGAGCCAGCATCTTCAAGTTCCACCCTCTGAGCAAGCACCTA GCTGTGACACACCTCTCCAGAGACTGCACTCCCCCCCGCGCCACCCACCCCAAAAGCAGA TAGGTAATGGTATACAGTAACCATTTCTAGAAGTGTAAGTAGTATGCACCCAAAATAGGC AAAACCTGCTGGCCTAGTGATAGAGACAACTCCCAGTCAGGCTAGACTGGAGGCCTTGGT TTTATAAGTGTTCAGGTGACAAGTGCCACAGTAGGCTTGATCAAGTAGACAGGCAGGCAA GACAAATGCTTACCAATGCAAGCTAATGAAATGTTTCTTTTGCAGAATTCCTGTCCTGTG AAGGAAGCCAACCAGAGTACGTTGGAAAACTTCTTGGAAAGGCTAAAGACGATCATGAGA GAGAAATATTCAAAGTGTTCGAGCTGAATATTTTAATTTATGAGTTTTTGATAGCTTTAT TTTTTAAGTATTTATATATTTATAACTCATCATAAAATAAAGTATATATAGAATCT OMIM ID 147780