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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for IL4R (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID3566
Official gene symbolIL4R
Full nameinterleukin 4 receptor
Aliases,CD124,IL4RA,
Gene summaryThis gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq]
LocationChromosome: 16   Locus: 16p12.1-p11.2
Gene position27325251 - 27376099  Map Viewer
Gene orientationplus
Gene size50849 bp
Gene sequence
OMIM ID147781