Entrez gene ID | | 3566 |
Official gene symbol | | IL4R |
Full name | | interleukin 4 receptor |
Aliases | | ,CD124,IL4RA, |
Gene summary | | This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 16 Locus: 16p12.1-p11.2 |
Gene position | | 27325251 - 27376099 Map Viewer |
Gene orientation | | plus |
Gene size | | 50849 bp |
Gene sequence |
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OMIM ID | | 147781 |
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