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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for IL4R (Homo sapiens)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0002532production of molecular mediator involved in inflammatory responseIEA
GO:0006955immune responseTAS
GO:0007165signal transductionTAS
GO:0030728ovulationIEA
GO:0035771interleukin-4-mediated signaling pathwayTAS
GO:0042127regulation of cell proliferationIEA
GO:0043032positive regulation of macrophage activationIEA
GO:0043627response to estrogen stimulusIEA
GO:0045626negative regulation of T-helper 1 cell differentiationIEA
GO:0045630positive regulation of T-helper 2 cell differentiationIEA
GO:0090197positive regulation of chemokine secretionIEA
cellular_component
GO:0005576extracellular regionIEA
GO:0005615extracellular spaceIEA
GO:0005886plasma membraneIEA
GO:0005887integral to plasma membraneTAS
GO:0016020membraneIEA
GO:0016021integral to membraneIEA
molecular_function
GO:0004872receptor activityIEA
GO:0004896cytokine receptor activityIEA
GO:0004913interleukin-4 receptor activityTAS
GO:0005057receptor signaling protein activityTAS
GO:0005515protein bindingIPI
GO:0043560insulin receptor substrate bindingRCA

Protein-protein interaction details for IL4R (Homo sapiens)
(Information is obtained from BioGRID)
Interacting human proteinExperimentTypePubMed ID
GNB2L1Reconstituted Complexphysical12960323
ARIH2Two-hybridphysical16169070
SHC1Affinity Capture-Westernphysical10652211
PTPN6Reconstituted Complexphysical11714803
INPP5DReconstituted Complexphysical11714803
SHC1Reconstituted Complexphysical11714803
PTPN11Reconstituted Complexphysical11714803
IL4Co-crystal Structurephysical11786020
JAK1Reconstituted Complexphysical12133952
NCF1Affinity Capture-Westernphysical10369419
HGSAffinity Capture-Westernphysical21362618
HGSReconstituted Complexphysical21362618
UBCAffinity Capture-Westernphysical21362618