Entrez gene ID | | 3586 |
Official gene symbol | | IL10 |
Full name | | interleukin 10 |
Aliases | | ,CSIF,IL-10,IL10A,MGC126450,MGC126451,TGIF, |
Gene summary | | The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1q31-q32 |
Gene position | | 206945839 - 206940948 Map Viewer |
Gene orientation | | minus |
Gene size | | 4892 bp |
Gene sequence |
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OMIM ID | | 124092 |
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