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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for IL12A (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 3592 Official gene symbol IL12A Full name interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) Aliases ,CLMF,IL-12A,NFSK,NKSF1,P35, Gene summary This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq] Location Chromosome: 3   Locus: 3q25.33-q26 Gene position 159706629 - 159713806  Map Viewer Gene orientation plus Gene size 7178 bp Gene sequence >IL12A:66201775..66208952:Length=7178 TTTCATTTTGGGCCGAGCTGGAGGCGGCGGGGCCGTCCCGGAACGGCTGCGGCCGGGCAC CCCGGGAGTTAATCCGAAAGCGCCGCAAGCCCCGCGGGCCGGCCGCACCGCACGTGTCAC CGAGAAGCTGATGTAGAGAGAGACACAGAAGGAGACAGAAAGCAAGAGACCAGAGTCCCG GGAAAGTCCTGCCGCGCCTCGGGACAATTATAAAAATGTGGCCCCCTGGGTCAGCCTCCC AGCCACCGCCCTCACCTGCCGCGGCCACAGGTCTGCATCCAGCGGCTCGCCCTGTGTCCC TGCAGTGCCGGCTCAGCATGTGTCCAGCGCGCAGTGAGTACTCAGCCCGCCAGGTCTTTG GCTCGCTCGGGTGCGGAGGGGCGGCTGCTTGGGAAGAGTGGGTAGAAACTCAAGTCTGCC TAAGGAGAGACTGGAACAGCAGCAGCCGTCTCCTGCAAAGAGGAATAAGAATAGGGGTCT CACCGTGTGCTAAATAGGGCATGTCTCTTTTCATCTCGAAACAGCCTGATGAGCTATCAT TATGCCCACTTCGTAGAGGAGAAACTGAGGCCCAGCGTGGGAGATTTCCTGCTTTCCTGC CTAGGGTCCCTCAGCTACAAACAGAAGGCAGATCCTAGCCAGTTCTAAAGTCAGGCTTGG CCGGGTGCAATGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGACAGATC TCCTGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAA CAAATACACAAATTAGCCGAGTGTGGTGGTGGGTGCCTGTAATCCCATCTACTCGGGAGT CTAAGGCAGGGAAAATTGCTTGAACTCGGAGGTGGAGGTTGCAGTGAGCCAAAATCGTGC CACTGCACTCCAGTCTGGGCCACAGAGTGAGACTCCGTCTTAAAAAAACAAAAAAAGTCA GGCTTTCTCACTCCACTGTTTTTAAAACACTGGGTCCCAAGTCTGACTCAGCCACTTCAC CACCTGGTCTGGGTTTCCCTGATCAAAAACATGTAGGCTTTCTCTGGGTGAGTGTTGGGT TCAACACCCTTGTCCAAGCTCATCTCTAGACCCTCACAGGGAGCTGGCTTCTAGCCCTAG AATAGAGTGGCGCTTTGTAATAACTCGAGTCATCTCTCAGGTGTTGAAGGAAAAGTGTTG GAAATGGGTTGAGGGAGGTGGGTGCCAAGCATGAATGGATGGGTGAAGGTGGCCAGAATG GAGGGAAGGTGGTGCAGGCAGGCCATCCAGGCTGAAGCTCCTCCACCTGCTCCTCTTCCT TCCAGGCCTCCTCCTTGTGGCTACCCTGGTCCTCCTGGACCACCTCAGTTTGGCCAGAAA CCTCCCCGTGGCCACTCCAGACCCAGGAATGTTCCCATGCCTTCACCACTCCCAAAACCT GCTGAGGGCCGTCAGCAACATGCTCCAGAAGGTGAGCCTTTCCTGTCCTCTCCACTGTGG ACCTGCACCCTCCCTGAGGAAGGGGCCTCTGATCCTCCCCTCTGGTACCTGATGGAACTG CAGAGAAATTGTGGAAGTTCATTAGCAGCTGTCAACAGCAGGAGAGGGAACTTTACAAAT GGCCCAAGTGTTAAAGAGTCCTAGTGAAATTGTGTCTCCAGAGAAAGCAAGAGTAGTAAT AAATTATAATGATGTTGGTTTTGGCTATGTCTACACTGAGTAAAGTGGATATTTGCAGTG TTCCTGTAGCCTGCCAACAGAGATAGAATTGTGTCAGGTCCACATGGTTTCTCTGGCACC ACACCACTGATCAATCCCGGAAATAGTTACTTGGGTGCATACTCTGTGTTGGGGGGCAGG GGTACAAAGATGAAATAGCCTTGTCCCTCCTGCTGCCCACCAGCTTCTACTTGGTGACAC AGTTCCTTCTTGGAGCAACACATCTCAGGGAGGACTATGACAGTGCACATGCAGCCTTCA TTTTCTAGGGAAGAGTTACCTAATTTTATTTACAGCTTCGTTCTTTTAGGTTTCATATTT TAATGTAAAAAACATTGCCGTTAAAAACTGCTCCAGTAGCTACTGCTGCAAAGGCTAAAG GCTAATGTTTTAAAAGATGTCCTCTGCCTTTCTGCTCTCTAGGAATTTTTTCTTGAGTAT TTTCTAGCTTGTTGCCTTAGGAATATCTTAAAATAAGCTCAATGCCACCAAGCCTTCTTA AAGGGCTCCTTTCCCCTTTCAATCTTTCATAATGTGCTGTGCATTGCTCCTCACAATTCA ATTAATCTTAATTGGACAGGGGGCTCAAGTGAAAACTGCTTTGTTTCCCGAAGAAAGGTT CAAAATGGGTAACTTTTAGGTGCTCCAATTCATATAGATTTTTTTGTGCAAAAGCTGACA CCCCTACTCCCAGATATAGTCCTAAGGGTCAAAAGATTATAGAAATCAATTTAATGTTTT GTACATCATTTGTCAAATTTGCTGTAGTAGAAAACAAATGAGGTAGATGCAAGTGATTCA CCGGCCATATCCAGGGCACAGGTTTGTAGAATTTGGGCTATATGTTTATTTTTTAGTTTG ATGCCATTCAAAAACCAAACATTTCAATTAAGATTTCAAAATTCTAGCTTCTCTTGAAAA GATCTGAAGAACAACACTGGACTCACACCTCCAAATCTAACTCTTTATAACCTGCTCAGA ATAGTGGGGTTGCCCAGGTCTGTTTAAACACCTCCGGGAATAGTGTATTCATTTCCTACT GCTGCTGTCACAAATGTAGTGGGTTTAAATGACACAAATTTATTATCTTACAGCTCTGGG CATCAGAAGTCCAAAATGGGTCCTACTGGGCTAAAGTCAATGTGTCAGCAGAGCTGTAGC CCTTTCTGGAGGCTCTTGGGGAGAATCTGTTGCCTTGCTTTGTCAGGTCTAGAGGCTGCC CACATTCCTTGACTTGTGGCCCCTTCCATTGTCCATACCAGCAATGTCTGGTTGAGTCTT TCTCATGCTGCTCCCTCTGGACTGACCTTCTACCCGCTTCTACTTTTGAGGACACTGCTT ACACTGGATTCACCCAGATAATCCAGGATCATCTCTCTACTCTTAGATCAGCTGATTAGC AAATTGAATGTCATCTGCACCTTCATTCCTCTTTGGCAGGTCACATAGCTCATTACCGGG TTCCAGGGATTGGGAGGTGGATGTCTTTGGAGGTGGAGAATTGGTCTAGCTACCACAGAA AGGGATTTTACTACTTGTGCCCAAACGTATTCTGAATTTTCAGGCCTTGCTTCTTGGCTC ATGCTGTTACCTCTGTCTGAAATTTCCCTCCTCCATTGTCGACACTTTACTCCTCTTAAT GTGGGTGTCCCAACTCTAGGAAGCTTTGCTTCCCTTCCTGCCCCTCCTCAGAAGCTTCAT GCCCTTCTCACCATGTCTCACCTACTGATGCCTCCTGGTCATTTGGGCAATTGTCTGTCT CAGCAGCTAAACTTGCAATCCAGGAGGGTATACATGGTCCTCTTCTCTGTCATGTTCTTA GTACCTAATGGAGTGCCTGCCACCCATTAGGCTGTTGAATGGAAAAATGATCGTAATCTT CAATCATACAGTCCTTTACTTCCTAAGATACATTTCATAATTTTACCCAACGGTGCTTTC CAACACACTAAGATGACATCTCTGTGTATGTGTGTGCGTGTGTGCACTGCAAATTAAATC TCAGCTTGTCTTAAGGGTTTGCATGTTTGTTATATCCATCAGACTGTGACCTTAACAGTT CCCCCTTTAGAAGTTATACTTGAAATAGGTATTCATAGAATACAGTCACTTTAGCAAAAG AAGAAACAATTTTCACCAGAAGCAAGTGTCACAGTGAGGTGTGGAGGCTGGTTAGCACAG GCTGTTGACATGATTTATTGTGTTTACATAATGAAAAAATATGTAATCCAGAGAAACATG CCCCAAGCTTAGGGAGAGGAGGGTGAGAGACAGAATGTAAGGAATCTATTTTCTTTTGTA TTATGAAGAACCAGAATTTCCTGCAAGTCAAAGTGACAGAGGTCAAGGGCAGCCAGCCGG AGCCTTCCTGGCACCCTGGCTTACCAGCCTTGTGGGGTGCCAGGTGCATTATCAATGTTA TAAACTGAGTTTCTCCTTCATTTTTTATAGGCCAGACAAACTCTAGAATTTTACCCTTGC ACTTCTGAAGAGATTGATCATGAAGATATCACAAAAGATAAAACCAGCACAGTGGAGGCC TGTTTACCATTGGAATTAACCAAGGTATAAAGGATTTTCCTCCCAGAGCATGCAGTGTGG TTAAAAACTGTGCATCAAATCTCACCTGCTTCTAAAAATTCACGTTTCTGGTATCCATCA TTATGGGATTTTAACTGGTCCTACTTCAGAAGTTAGATTTGGGAGAAAAATTATTTTTAA AAAATGGTTTTTTTTGCAACAATGTGAATACACTTAACACTTAAAAATAGTTCAGATGCT AAATATTATGATATGTGTTTTTACCATAATAAAAAAAATTTGAGACCTGAAGAGTCAGAA AGATTTATACTAAGAATTAATACTTTGATATATGATTTTTTCCCTCTAGAATGAGAGTTG CCTAAATTCCAGAGAGACCTCTTTCATAACTGTAAGTCAAAAAATGAAAAGTTTCAGCCT GTATGATGAATTCATATCACTGATGTCTGATTATTTTTTCCTCTAGAATGGGAGTTGCCT GGCCTCCAGAAAGACCTCTTTTATGATGGTAAGACACACAGCTCTTTCCTCAAATGCAAT GGGGGAAATGTTTTTAGCCCATCTCAATGGATACTTCCCCATCTTGTCATGTCACCCAGG CCCTGTGCCTTAGTAGTATTTATGAAGACTTGAAGATGTACCAGGTGGAGTTCAAGACCA TGAATGCAAAGCTTCTGATGGATCCTAAGAGGCAGATCTTTCTAGATCAAAACATGCTGG CAGTTATTGATGAGCTGATGCAGGTAAGACTTCATTCTATCAGTGAGAGCACCTTTTTCA TGCTAAAGATAACCAGCCAGGGTCTTTGATAAAGAGATATAAAAAGAGGTCTGGAGGCCT TTTAAAGGCCTGACAGACCTACATTTTCAAGAAGACAGCCTTGAGGGTGCCGTCTATAGG GAGCACAAATGTGAGCAGATCACATTATGAAAAGCAGACTCCAAAGTATTCACTCTGTGG TATCCCCCACACTCGGCAAATGTTTTTGTGCATTTTCTTATGTCAGCCTCAAAACAACCA TATGGGATCTGCACAAAGGAGGGAACCAAACCTTAGGAGAGTTAAACCACTTGTCTGAGG CTCTGCCTCTTAAAATCCTTCAAGAGGATTTCACTACACTTACCTTCTCACTCACCTCTA AAGGCTCCAGGACGTGCTCCAGGATGTGCATGCAAGGGGCCAGTTTGCATATCTGCAAAT ATTGCTGGGAAACAAGCAAGATTGGTGCCTGATTATGACCCATTGTGAACCAAAATGTGA ACCAAATAAAAGAATGACCTATCATCTGGGGCATCTATAATGTTATTCATAGGCAAGAAC TTGCTTTGTTATGTTCTGAATCACCATAACACAGATGCTAATATAAAACAAATATTTATA TAAGCGAGGGTGACTGCTTTGGTGACGAGGACATGGGATAAAAATATGGTGGCAGAAATC ATTGTCTGAAAAGTAATTGTTTTACTTTTATTCTTTTCGTGTGTGTGTGTGTGTGTGTGT GTGTGTGTGTGTGTGTGCATGTGCCAGATTTCTTGTTTGAAAGGCAATGAGCTTCATCCA AGTATCAAAGAATGTTAGCATCTAGAGAGCTGTAGTTGCTATTTCATTTTTAGGACCAAG AGTTGGGTGATTTGGGTGCTAGAATCAATTCTACCAGTAACCAGACAACTATTCCCAAGT CACTTAACCCCTCTGTGCCTCAGTTTCCTCCAGTATAAAATGGGGTGACTTTATTCTAGC TTTCTTTTAGACTTTTTGTGAGGAAGATATGAAAGTATTTATTCATCAAGGGTGCAAATG TAAGGTTTTATATTCTGTTATCAAATCAAAGTGCTAAACTTGGGAAATTCATTGCCAGGT TTATCTGACACAAATGGCATGTCTTCAGTAAACAGGCCTGTTACTGATAGTGAGTTCTGA TCAATAGCAATCCATCACCTCCCTGTGCTAAACAGAAGTGGGCTTTTTAATGTAACATAT ATAAAATTAATTAGATATTGCAGCAGATGTCATTTTAAAGGAACTGTTTCTTTCTAAGAC ACAACTCCCACTGATGATTTTTTCTAAATAGTTTTAAGGGTCTTTTCAGAGCTCATTGAA GATGGATGTGCTTGGAAAATGAGTATTTCTTTTCTCATTCTGCCTGGTGATCTGGCTGAG AGTAGATTTGGATTGGGTTTAGGAGTGGCATAAGGGACTGAGTTGCAGGCTCTGAGACAT GTACTGGCTTCACTCATTTTTATGAATGAATATTTGAATTTTGGAATACCATGTAAGTCA TGCTTACTGTTCATTCTCCTAGGCCCTGAATTTCAACAGTGAGACTGTGCCACAAAAATC CTCCCTTGAAGAACCGGATTTTTATAAAACTAAAATCAAGCTCTGCATACTTCTTCATGC TTTCAGAATTCGGGCAGTGACTATTGATAGAGTGATGAGCTATCTGAATGCTTCCTAAAA AGCGAGGTCCCTCCAAACCGTTGTCATTTTTATAAAACTTTGAAATGAGGAAACTTTGAT AGGATGTGGATTAAGAACTAGGGAGGGGGAAAGAAGGATGGGACTATTACATCCACATGA TACCTCTGATCAAGTATTTTTGACATTTACTGTGGATAAATTGTTTTTAAGTTTTCATGA ATGAATTGCTAAGAAGGGAAAATATCCATCCTGAAGGTGTTTTTCATTCACTTTAATAGA AGGGCAAATATTTATAAGCTATTTCTGTACCAAAGTGTTTGTGGAAACAAACATGTAAGC ATAACTTATTTTAAAATATTTATTTATATAACTTGGTAATCATGAAAGCATCTGAGCTAA CTTATATTTATTTATGTTATATTTATTAAATTATTTATCAAGTGTATTTGAAAAATATTT TTAAGTGTTCTAAAAATAAAAGTATTGAATTAAAGTGA OMIM ID 161560