| Entrez gene ID | | 3716 |
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| Official gene symbol | | JAK1 |
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| Full name | | Janus kinase 1 |
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| Aliases | | ,JAK1A,JAK1B,JTK3, |
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| Gene summary | | Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq] |
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| Location | | Chromosome: 1 Locus: 1p32.3-p31.3 |
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| Gene position | | 65432187 - 65298906 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 133282 bp |
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| Gene sequence |
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| OMIM ID | | 147795 |
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