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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for JAK1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006468 protein phosphorylation TAS GO:0007243 intracellular protein kinase cascade IEA GO:0019221 cytokine-mediated signaling pathway TAS GO:0035556 intracellular signal transduction TAS GO:0046677 response to antibiotic IDA GO:0060333 interferon-gamma-mediated signaling pathway TAS GO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS GO:0060337 type I interferon-mediated signaling pathway TAS GO:0060338 regulation of type I interferon-mediated signaling pathway TAS cellular_component GO:0005634 nucleus IDA GO:0005737 cytoplasm IDA GO:0005829 cytosol TAS GO:0005856 cytoskeleton IEA GO:0012505 endomembrane system IEA GO:0016020 membrane IEA molecular_function GO:0000166 nucleotide binding IEA GO:0004713 protein tyrosine kinase activity EXP GO:0004713 protein tyrosine kinase activity TAS GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA GO:0005131 growth hormone receptor binding ISS GO:0005515 protein binding IPI GO:0005524 ATP binding IEA

Protein-protein interaction details for JAK1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID ATIC Affinity Capture-MS physical 17353931 ARRB1 Affinity Capture-MS physical 17353931 ELF3 Affinity Capture-MS physical 17353931 STAT3 Reconstituted Complex physical 11751884 ABL1 Reconstituted Complex physical 9774693 ABL2 Affinity Capture-Western physical 9774693 GNB2L1 Affinity Capture-Western physical 12960323 GNB2L1 Reconstituted Complex physical 12960323 IL27RA Affinity Capture-Western physical 12734330 PRMT5 Reconstituted Complex physical 10531356 SHB Reconstituted Complex physical 12200137 IL10RA Reconstituted Complex physical 12374810 PTK2B Affinity Capture-Western physical 10702271 TEC Affinity Capture-Western physical 9178903 BTK Affinity Capture-Western physical 9178903 STAT3 Affinity Capture-Western physical 11722592 IRS1 Biochemical Activity physical 9492017 IGF1R Reconstituted Complex physical 9492017 BRCA1 Affinity Capture-Western physical 11163768 IL2RB Affinity Capture-Western physical 7973659 IL6ST Affinity Capture-Western physical 11468294 IL6ST Reconstituted Complex physical 11468294 STAM2 Biochemical Activity physical 10993906 PTPN11 Reconstituted Complex physical 8995399 PTPN11 Biochemical Activity physical 8995399 TYK2 Affinity Capture-Western physical 7589562 TNFRSF1A Reconstituted Complex physical 9510175 STAT5B Two-hybrid physical 9047382 STAT5A Two-hybrid physical 9047382 STAT5A Affinity Capture-Western physical 9047382 STAT5B Affinity Capture-Western physical 9047382 STAT5A Affinity Capture-Western physical 9047382 STAT5B Affinity Capture-Western physical 9047382 STAT5A Reconstituted Complex physical 9047382 PTPN11 Affinity Capture-Western physical 12403768 IL2RB Affinity Capture-Western physical 7973658 IRS2 Affinity Capture-Western physical 7499365 IRS1 Affinity Capture-Western physical 7499365 ELP2 Affinity Capture-Western physical 10954736 ELP2 Reconstituted Complex physical 10954736 IL21R Affinity Capture-Western physical 11016959 GRB2 Affinity Capture-Western physical 11527382 CSF3R Affinity Capture-Western physical 7512720 IL5RA Affinity Capture-Western physical 9516124 IL9R Affinity Capture-Western physical 8756628 PTPN6 Biochemical Activity physical 7629131 PLAUR Affinity Capture-Western physical 9417082 IL6ST Affinity Capture-Western physical 9388212 IFNAR2 Reconstituted Complex physical 12133952 IL2RB Reconstituted Complex physical 12133952 IL4R Reconstituted Complex physical 12133952 IFNGR1 Reconstituted Complex physical 12133952 IL10RA Reconstituted Complex physical 12133952 GRB2 Reconstituted Complex physical 8536716 TSHR Affinity Capture-Western physical 10809230 IL6ST Affinity Capture-Western physical 11742534 STAM2 Affinity Capture-Western physical 10899310 GHR Affinity Capture-Western physical 10502458 RAF1 Affinity Capture-Western physical 9446616 TNFRSF1A Affinity Capture-Western physical 11801527 IL2RB Affinity Capture-Western physical 9553136 IL2RB Affinity Capture-Western physical 9774657 EIF2C4 Affinity Capture-MS physical 19167051 CSF2RB Affinity Capture-Western physical 21965659 TIRAP Affinity Capture-MS physical 21903422 UBC Affinity Capture-MS physical 21987572