Entrez gene ID | | 4035 |
Official gene symbol | | LRP1 |
Full name | | low density lipoprotein receptor-related protein 1 |
Aliases | | ,A2MR,APOER,APR,CD91,FLJ16451,IGFBP3R,LRP,MGC88725,TGFBR5, |
Gene summary | | The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12q13-q14 |
Gene position | | 57522282 - 57607142 Map Viewer |
Gene orientation | | plus |
Gene size | | 84861 bp |
Gene sequence |
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OMIM ID | | 107770 |
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