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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for LRP5 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID4041
Official gene symbolLRP5
Full namelow density lipoprotein receptor-related protein 5
Aliases,BMND1,EVR1,EVR4,HBM,LR3,LRP7,OPPG,OPS,OPTA1,VBCH2,
Gene summaryThis gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. [provided by RefSeq]
LocationChromosome: 11   Locus: 11q13.4
Gene position68080108 - 68216743  Map Viewer
Gene orientationplus
Gene size136636 bp
Gene sequence
OMIM ID603506