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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for LRP5 (Homo sapiens)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0001702gastrulation with mouth forming secondIBA
GO:0002053positive regulation of mesenchymal cell proliferationIMP
GO:0002076osteoblast developmentIBA
GO:0006007glucose catabolic processIMP
GO:0006897endocytosisIEA
GO:0007275multicellular organismal developmentIEA
GO:0008217regulation of blood pressureIMP
GO:0008284positive regulation of cell proliferationIDA
GO:0009952anterior/posterior pattern specificationIBA
GO:0016055Wnt receptor signaling pathwayIDA
GO:0030326embryonic limb morphogenesisIBA
GO:0042632cholesterol homeostasisIMP
GO:0044332Wnt receptor signaling pathway involved in dorsal/ventral axis specificationIDA
GO:0045600positive regulation of fat cell differentiationIMP
GO:0045668negative regulation of osteoblast differentiationIMP
GO:0045840positive regulation of mitosisIDA
GO:0045893positive regulation of transcription, DNA-dependentIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0046849bone remodelingIBA
GO:0048539bone marrow developmentIMP
GO:0048596embryonic camera-type eye morphogenesisIBA
GO:0060042retina morphogenesis in camera-type eyeIMP
GO:0060059embryonic retina morphogenesis in camera-type eyeIBA
GO:0060070canonical Wnt receptor signaling pathwayIDA
GO:0060070canonical Wnt receptor signaling pathwayIMP
GO:0060349bone morphogenesisIMP
GO:0060444branching involved in mammary gland duct morphogenesisIBA
GO:0060612adipose tissue developmentIMP
GO:0060828regulation of canonical Wnt receptor signaling pathwayIMP
GO:0061178regulation of insulin secretion involved in cellular response to glucose stimulusIBA
GO:0061304retinal blood vessel morphogenesisIMP
GO:0071901negative regulation of protein serine/threonine kinase activityIMP
cellular_component
GO:0005783endoplasmic reticulumIEA
GO:0005886plasma membraneIDA
GO:0016020membraneIEA
GO:0016021integral to membraneIEA
GO:0043235receptor complexIDA
molecular_function
GO:0004872receptor activityIEA
GO:0005515protein bindingIPI
GO:0015026coreceptor activityIBA
GO:0017147Wnt-protein bindingIBA
GO:0019534toxin transporter activityIMP
GO:0042813Wnt-activated receptor activityIBA

Protein-protein interaction details for LRP5 (Homo sapiens)
(Information is obtained from BioGRID)
Interacting human proteinExperimentTypePubMed ID
MESDC2Affinity Capture-Westernphysical12581525
FZD8Affinity Capture-Westernphysical11448771
AXIN1Affinity Capture-Westernphysical11336703
AXIN1Affinity Capture-Westernphysical11336703
AXIN1Affinity Capture-Westernphysical18632848