Entrez gene ID | | 409 |
Official gene symbol | | ARRB2 |
Full name | | arrestin, beta 2 |
Aliases | | ,ARB2,ARR2,BARR2,DKFZp686L0365, |
Gene summary | | Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq] |
Location | | Chromosome: 17 Locus: 17p13 |
Gene position | | 4613789 - 4624795 Map Viewer |
Gene orientation | | plus |
Gene size | | 11007 bp |
Gene sequence |
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OMIM ID | | 107941 |
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