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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for ARRB2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001932 regulation of protein phosphorylation IEA GO:0002031 G-protein coupled receptor internalization IDA GO:0002031 G-protein coupled receptor internalization IMP GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin IMP GO:0006366 transcription from RNA polymerase II promoter IDA GO:0007179 transforming growth factor beta receptor signaling pathway IDA GO:0007596 blood coagulation TAS GO:0007628 adult walking behavior IEA GO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA GO:0015031 protein transport IEA GO:0016567 protein ubiquitination IMP GO:0030168 platelet activation TAS GO:0031397 negative regulation of protein ubiquitination IDA GO:0031623 receptor internalization IDA GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA GO:0032226 positive regulation of synaptic transmission, dopaminergic IEA GO:0032691 negative regulation of interleukin-1 beta production IEA GO:0032695 negative regulation of interleukin-12 production IEA GO:0032715 negative regulation of interleukin-6 production IEA GO:0032720 negative regulation of tumor necrosis factor production IEA GO:0034122 negative regulation of toll-like receptor signaling pathway IEA GO:0043161 proteasomal ubiquitin-dependent protein catabolic process IMP GO:0045953 negative regulation of natural killer cell mediated cytotoxicity IMP GO:0051897 positive regulation of protein kinase B signaling cascade IEA GO:0060326 cell chemotaxis IMP GO:0070374 positive regulation of ERK1 and ERK2 cascade IDA GO:0070374 positive regulation of ERK1 and ERK2 cascade IMP cellular_component GO:0005622 intracellular IEA GO:0005634 nucleus IDA GO:0005737 cytoplasm IDA GO:0005829 cytosol TAS GO:0005886 plasma membrane IDA GO:0005905 coated pit IEA GO:0016023 cytoplasmic membrane-bounded vesicle IEA GO:0031410 cytoplasmic vesicle IDA molecular_function GO:0001664 G-protein-coupled receptor binding IPI GO:0005102 receptor binding IPI GO:0005515 protein binding IPI GO:0031625 ubiquitin protein ligase binding IPI GO:0031701 angiotensin receptor binding IPI GO:0043422 protein kinase B binding IEA

Protein-protein interaction details for ARRB2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID RALGDS Two-hybrid physical 12105416 NOLC1 Affinity Capture-MS physical 17353931 TCOF1 Affinity Capture-MS physical 17353931 DDX27 Affinity Capture-MS physical 17353931 AP3B1 Affinity Capture-MS physical 17353931 KPNA3 Affinity Capture-MS physical 17353931 KPNA4 Affinity Capture-MS physical 17353931 BOP1 Affinity Capture-MS physical 17353931 ARRB1 Affinity Capture-MS physical 17353931 MRPL44 Affinity Capture-MS physical 17353931 MRPL43 Affinity Capture-MS physical 17353931 FBL Affinity Capture-MS physical 17353931 PES1 Affinity Capture-MS physical 17353931 RPL7L1 Affinity Capture-MS physical 17353931 RAB5C Affinity Capture-MS physical 17353931 SMARCC2 Two-hybrid physical 16169070 MED8 Two-hybrid physical 16169070 STC2 Two-hybrid physical 16169070 MAPK10 Affinity Capture-Western physical 11356842 RALGDS Affinity Capture-Western physical 12105416 RALGDS Affinity Capture-Western physical 12105416 ARF6 Affinity Capture-Western physical 11533043 CYTH2 Affinity Capture-Western physical 11533043 CYTH2 Reconstituted Complex physical 11533043 OPRD1 Reconstituted Complex physical 11259507 MDM2 Affinity Capture-Western physical 12488444 MDM2 Affinity Capture-Western physical 12488444 AVPR2 Affinity Capture-Western physical 12473660 MAPK3 Affinity Capture-Western physical 12473660 MDM2 Affinity Capture-Western physical 12538596 LHCGR Reconstituted Complex physical 11867621 PTAFR Affinity Capture-Western physical 11729201 AP2B1 Two-hybrid physical 10097102 AP2B1 Reconstituted Complex physical 12070169 MAP3K5 Affinity Capture-Western physical 11090355 MAP2K4 Affinity Capture-Western physical 11090355 NEDD4 Affinity Capture-Western physical 18544533 MDM2 Affinity Capture-Western physical 18544533 ITCH Affinity Capture-Western physical 18544533 ITCH Affinity Capture-Western physical 17947233 ITCH Reconstituted Complex physical 17947233 CDC42 Two-hybrid physical 20936779 UBC FRET physical 15782195 UBC Affinity Capture-Western physical 15782195 UBC Affinity Capture-Western physical 15699045 MAPK1 Affinity Capture-Western physical 15699045 UBC Affinity Capture-Western physical 12574160 UBC Affinity Capture-Western physical 11588219 MDM2 Biochemical Activity physical 11588219 DRD4 Affinity Capture-Western physical 20100572 USP33 Affinity Capture-Western physical 19424180 GPR56 Affinity Capture-Western physical 21708946 USP33 Affinity Capture-Western physical 19363159 UBC Affinity Capture-Western physical 19363159 USP33 Reconstituted Complex physical 19363159 PARK2 Affinity Capture-Western physical 21466165 PARK2 Affinity Capture-Western physical 21466165 PARK2 Reconstituted Complex physical 21466165 UBC Affinity Capture-Western physical 21466165 MDM2 Affinity Capture-Western physical 21466165 IGF1R Affinity Capture-Western physical 19165858 MAP3K5 Affinity Capture-Western physical 19306926 STUB1 Affinity Capture-Western physical 19306926 TRAF3 Affinity Capture-Western physical 11226259 MAP2K1 Affinity Capture-Western physical 11226259 MAPK1 Affinity Capture-Western physical 11226259 AGTR1 Affinity Capture-Western physical 11226259 AKT1 Affinity Capture-Western physical 18191226 AKT1 Reconstituted Complex physical 18191226 MDM2 Co-localization physical 21389118 MDM2 Affinity Capture-Western physical 21389118 MDM2 Affinity Capture-Western physical 21389118