Entrez gene ID | | 4172 |
Official gene symbol | | MCM3 |
Full name | | minichromosome maintenance complex component 3 |
Aliases | | ,HCC5,MGC1157,P1-MCM3,P1.h,RLFB, |
Gene summary | | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. [provided by RefSeq] |
Location | | Chromosome: 6 Locus: 6p12 |
Gene position | | 52149582 - 52128812 Map Viewer |
Gene orientation | | minus |
Gene size | | 20771 bp |
Gene sequence |
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OMIM ID | | 602693 |