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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MCM4 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 4173 Official gene symbol MCM4 Full name minichromosome maintenance complex component 4 Aliases ,CDC21,CDC54,MGC33310,P1-CDC21,hCdc21, Gene summary The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq] Location Chromosome: 8   Locus: 8q11.2 Gene position 48873494 - 48890068  Map Viewer Gene orientation plus Gene size 16575 bp Gene sequence >MCM4:737895..754469:Length=16575 GGGTCTCGCGGTTTGGGAGCGCTACTCGCCAGGTGGACTCGGAGTCCGCGAGCGTCGTCG GCAAGCGGCCGCCTTTCCACGGTAACCGCGCGCCGGCGGGGAGGGCGTGGCGCGGAGCCG ACGGGAACGTCCGCGCTGCGGAGCAGGGCAGGGAAGCCGGGAGGCGGGCCCGGCCCGAGC TTGTCCTTGTCGCGCAGGTACTCCGAGCACTATGTCGTCCCCGGCGTCGACCCCGAGCCG CCGCGGCAGCCGGCGTGGAAGGGCCACCCCCGCCCAGACGCGTGAGTCCCCCGAGCCGGG CCCACTACAGCCCCCGGCGCCGCCCCGTCTGCCCTCTCGCCGCAGCTGGCAGCGCTGGGT GGGTGCGCGGGACCCGGGCGCTCAGCCTCGGGCTGGGCGCTGCCGCTTGGTGCGCACAGA CACCCACAGCAGGCTGTGGCCTGGGTGCTGCTTAATTCGATTGCCATTTGCCTCTGTTTG GTTTGGTTCAGTGGTGAGTCATAATGCCCCAAGGAAAAGACAAATCCAGGAAGGCCGGCC CTGAAAGTTAATGGCTGTCTTTTCTGTTTTGTGTGACACAAGCTCGGAGTGAGGATGCCA GGTCATCTCCCTCTCAGAGACGTAGAGGCGAGGATTCCACCTCCACGGGGGAGTTGCAGC CGATGCCAACCTCGCCTGGAGTGGACCTGCAGAGCCCTGCTGCGCAGGACGTGCTGTTTT CCAGCCCTCCCCAAATGCATTCTTCAGGTGCGTGTCTGAAGATCTTGGTTTTGCTGTGCT TGATACACAGCTGATGCTTTATCTGCTCAGGTTTACTGGCTTTATAACAGTTGGCATAAC GCCTAAAGCATCCCCTCTGCACGTGACTGAGCATGTTCTTAACCAGAGGAGCTGAACGGA GTGCAGAAAATAGTAGTTTTAGGGCTTAGTGAGCAGAGGAAGCAGCTTCTCTGGTGCTTT TTTTTAATAGAACATTTAAGAGTGCTCAGAATCTCAGCCACCGCAGGTTGCAATAAATAT TCAGTTTGCTGTTGCGATTAGATGGTATAGATCAACAGACAACATGCTGTAATTTCAGGT TTGATATGCCACCAGAATTTCCTAATTTTGTTTTTATAGCTATCCCTCTTGACTTTGATG TTAGTTCACCACTGACATACGGCACTCCCAGCTCTCGGGTAGAGGGAACCCCAAGAAGTG GTGTTAGGGGCACACCTGTGAGACAGAGGCCTGACCTGGGCTCTGCACAGAAGGGCCTGC AAGTGGATCTGCAGTCTGACGGGGTGAGTATGCAGTCTCCTGAAACCATCTTATGGCGGG TATCATGTGGGTAACTCTGTTTTCATGATTCTGTCATGTTTTTCTGTGTAGGCAGCAGCA GAAGATATAGTGGCAAGTGAGCAGTCTCTAGGCCAAAAACTTGTGATCTGGGGAACAGAT GTAAATGTGGCAGCATGCAAAGAAAACTTTCAGGTGAGCTACATGTATTAAAATTCTTAC TTTGGGCTCTGAAAATGTTGGGAGACCGTGTTTATAATCTATATCTAAGTAGCCATAATG ACTAGAAGGGCCACCTGTGGTGGCTCACACCTATAATCCCAGTACTTTGGGAGGCCAAGG TGGGAGGATCACTTGAGGCCAGGAGTTTGATAGCAGCCTGACCAATATAGTGAGACTCCA TCTCCAAATTAAATTTTAGAAAAGAAAAAGGAAGAAAAATATTATTTATTTCTGTCTCCT GATAGTGACATACTCATAACTTTGTGTGTTTTTAGTAGTTGCCTGTTCCCAAATGCTATA TGCCTAATACAGTTTTCTCTCCACTTAAAGAGATTTCTTCAGCGTTTTATTGACCCTCTG GCTAAAGAAGAAGAAAATGTTGGCATAGATATTACTGAACCTCTATACATGCAACGACTT GGGGAGGTAATCAAATACTCTTTAAATTCAAGTTACGTGTTTTAAAATAGTTAAATTAGC AAAATATAACTTGTTCATTTTTATTTTCTAGATTAATGTTATTGGTGAGCCATTTTTAAA TGTGAACTGTGAACACATCAAATCATTTGACAAAAATTTGTACAGACAACTCATCTCTTA CCCACAGGTAAGAATTTAGCTTTGACCTTGATGAATTTTAGTAACAGTCTAGAAAGAATG TTTCCAGATAACAGAAATTCTTCAGTAATGAAGATAGTATGCGCAAACACTTTAAGAAAC TGAGTATCATCTCCTTTGGCCCGGTGTGGTGGCTCACACCTATAATCCCAGCACTTTAGG ACGCCGAGGCAAATGGATCACTTGAGGTCGGAAGTTTGAGACCAGCCTGGGCAACAAAGT GAAACCCCATCTGTACTAAAAAATACAAAAATTAGCCAGACATGGTGGTGCATGCCTGTA GTCCCAGCTACTCGGGAGTCTGAAGCGATAGAATCACTTGAACCCCGGAGGCAGAGGTGC AGTGAGCCGAGATGGCACCACTGCTCTCCAGCCTGGGCAACAGTGAGATTCCATCTCAAA CAAACAAAAAAAAACTATGTATCATCTCCTTTAAGATGAACATTTTTTTTTCACATTTTA ATGTTCCTGAAAGTGGGACTTGTATTACTATCAATGACAGGTTATGGTTTACTTGGCAGT GTTTTTCATGTAGAAAAATGATGAATCTTAAAACTGATAGCTTCTTGGGTTTCATGAAGT AAGTTATCTTAAATGGAAATACTTTAAATGAATTACATACTTCCTGCTGCTTTGAAAGAA TATATTGTACTGTAGACTTTTACTTCTAAGCCTCAGGTCAGTTTCTATTAATGAAGTATC AGCTCTGTTGACTCTGGGTGTAGTCTTTGGAGGCAAGCAGACTTGGTTTTTGAATCTTGG TTTTGCTGATTACTGGCTGCATAACCTTGGTCAAGTTCCTTAGCCAACCAAAAGCTGTTT CCTCATCTGTAAAATGGGAACCATATGTTAAGAAATTTGAATAAATATGATTTAACTTAC TTTGGTATCGCCAGGCACGGTGGCTCATGCCTGTGATCCCAGCACTTTGGGAGGCCGAGG CAGGCAGATCACCTGAGGTTGGGAGTTCAAGACCAGCCTGACCAACGTGGAGAAACCCCG TCTCTATTAAAAATACAAAATTAGTCAGGCGTGGTGGCAAATGCCTGTAATCCCAGCTAC TCGGGAGGCTGAGGCAGGAGAATTACTTGAATCCCAGAGGCAGAGGTTGCAGTGAGCCAA GATCATGCTGTTGCACTCCAGCCTGGGCAACAAGAGTGAAACTCTGCCTCAAAAATTAAA AATAAATAAATAAAAAACTTACTTTGGTATCACTTCATTATAGAAGGAAAATAAAGTGTG AGGTCAAAATCTTTTTCCCTTCTAATAGAAAGCAAAGAATATGCCAGTATACATCAAGAA GGCACTTTCGTATAAATTATGAAATTTAACCCAATTGAAAATATGCAGAAATAGATAGTT CAGCATACCTAAATTTGAAAACAGCACGTGCATGATTCTGTAGGGTAATACTTTGGGGAC ATGACATGTTGTCTTTTTATACTTTGCTAATCTGACATGCCTTTATTATATTTAACACTG AGATATGAATACAAATACATCTTCATATTTGTTTTTACAGGAAGTTATTCCAACTTTTGA CATGGCTGTCAATGAAATCTTCTTTGACCGTTACCCTGACTCAATCTTAGAACATCAGAT TCAAGTAAGACCATTCAACGCATTGAAGACTAAGAATATGAGAAACCTGAATCCAGAAGG TAATGTATTTTTCATAGGATTACTTTTGTTGAAGGAAAATGCCTTACATGAAAATAGCCT TGTTTTCATTGAGAAATTATGAAAGAAGTAATTGGCGGTGGTAGTCAAGGTGACGGATTA TAAATTGACAATAATATAGATTCAGTTATCCTATATACTTATGAACCCCCTATACTTTTT AAATTTAATTGAAGTTTCTGATATAAGAGATGTGACTATTGGCCGGGCACAGTGGCTCAC GCCTATAATCCCAGCACTTCAGGAGGCCGAGGCAGGCGGATCACCTGAGGTCAGGAGTTT GAGACCAGCCTGGCCAACATGGCAAAACTCCTTTACTAAAAATAGAAAAATTACCAGGGC ATGGTGGCACACGCCTGTAGTCCCGGCTACTCTCGGGAGGCTGAGGCAGGAGAAACGCTT GAACCCGGGAGGCGGAGGTTGCACTGAGCAGAGGCTGTGCCATTGCACTCCAGCCTGGGT GACAGAATGAGACCCTGTCTCAAAAAAAAAAAAAAATTAGATTTTAAAGATTTGAGGATC ACTTGAGGCCAGGAGTTTGAGACCAGCTTGAGTGACATAAGAGACTCCATCTCTTTTTAA GAAGAAATTAGCAAGGCACAGTGGCTCACACATGTAATCCTAGCACTCTGGGAGGCTGAG GTGACGGGCTTACTTGAGCCTGGCAGGTTGAGGCTTCAGTGAGCAGTGATTGCACCACTG TACTCCAGTCTGGGCAACAGGTTAAGACCCCATCTCAACAACAACAAAATTGTAGAGGTC TCATGAATCAGTGGCAGGATAGGGTGATCTTCACGGCTAGCAGTGGCTAAATACAGGCCA GAACAGGGTAGCTTGTCTGAAACCAGCAGGGGAAATTAGTTGCGGGCAGTGGGACCTTCA AAGGGAAAAAGTTGTCTGTCAGGAAAGGTTCAAATAATAGAGGAAACGAGCAAGAGTGAA AGATCAGAGCATCTAAGGGGTTCTCCTGTGTGGATAATAATGACTTTAAAGTATAGAGGA CTTTTTCTCTACCAGGTGCTCTTACTAGGCTTGAAGTACATTGGCACGTTCAGTCCTTGG CTCTGGGATAGGTGCTGATACCACCCCATTCTATAGGGGACACAAAATGTACACAGAAAG GCTAGGGTCAGGACTCAGTCCAGGCTGTCTGGCTTTTTTCCTGACACAGCAGGGTGTCAT ACAGGAGGCCAGGTGAGTGAGGCAGGAGGCAGGGAGCAGGGTAGGCAGACAAGAAGGGAA CGAGGGATGCCTGCTGGACAGGGGCCCTGAGGAAGAAGGGCCAGAGGTTCGCTGGGCTTG AGAGTCTCCTGAAGACATAGCCTGCAGATGACTGGACACAGAAAGGTCGCCCTAGGCAGA GTCTTGGGCACCTAGCTCCTGTCTGTGATCCCAGCTATTCCTGGACCTCCACACCTCAGG TCAGGTGTGCTGACCTCTCTTCTCCCCTCACAGACATTGACCAGCTCATCACCATCAGCG GCATGGTGATCAGGACATCCCAGCTGATTCCCGAGATGCAGGAGGCCTTCTTCCAGTGCC AAGTGTGTGCCCACACGACCCGGGTGGAGATGGACCGCGGCCGCATTGCAGAGCCCAGTG TGTGCGGGCGCTGCCACACCACCCACAGCATGGCACTCATCCACAACCGCTCCCTCTTCT CTGACAAGCAGATGGTGCGCAGCCACCCTGGCCCCCCAGGCTATGCTTTGCCTGTCTGTA TCCTCAAAAGGCCAACTATAACTTGTCCCTCGGACCCTGAGCCTCACTTCCCGAATGGCA TCCATCCCTCTCTGGTCTTGTGGGTTTCGTTAGTGGCCTATGGGCTAAATATGCAGAGCA CGCAAAGCCCCTGCTTCAGGGCACTGTCCCTGTGCTGTTGCCAGTGGCACTGTCTGTTGT TAGAGACACTGTATTTTCATGGCCTAAAATGCTTCAAACGTTTGAGATGAGAATACTTGG TTAAATGTCATTCTGCTTTTTCCATTGGTAAAGGATTGAGGAATTTTTCTGAAATTTTTT CACAAATTTTACTGTCTAAGAAGTTTGGTCTTTTTTCTCTATATTCATGAAATTTTAAGA TGAAGTTATTAAAATGACAGAAAAAAGTGAGGGGAAGGTAGAAAATTGCTTATTTACCGT GATTGTGACTGTAAAGATGTGGGAGGACAGGATTTGAGTTTTTCTGTGACTGCGTGTGCA TGGTTTCTTTAATGTTGCATGGGATGGAGAGCTGGAGACAGAAAGGCAGGCACCCTGCTC CGCAGGAGCACATGGCCTCCTATTCTCAGAATCATGCAGGCCCCCAAAGTGGCTTAGAGA AAAGCCCAGCATCCTTAGGCCTCTCAGAGGGTACCTGGTTTGGAAAGGCCTTCCTCGACC CTGCTTTATGAAAAGCATCTCAGCTTCCCCCACCGCAGCTCCCTACATTCCTTCCCCTGT TTTGTTGCTGTCTGTTGCAGCAACTTCTTTAGAAGAAGTAATTTCTAAGGAAATAATGAG AAACATGGACAATCATTTATGTGGGGATATGCACTGCAGCCTTATATGGCAAAAGCAGTA CAAAGACATGCAGATTTTGTCCCCCTGCCCTCTCTTTGTGGCCCACATGTTCTCTGTTTG CTGACCTTCAGATCAAGCTTCAGGAGTCTCCGGAAGACATGCCTGCAGGGCAGACACCAC ACACAGTTATCCTGTTTGCTCACAATGATCTCGTTGACAAGGTCCAGCCTGGGGACAGAG TGAATGTTACAGGTAAGAGTGTAGGTTTGCACCAGCACTTGAGCATGTCTGGCTTGCTTT CAATGCTGTGCTTTAGTGAGTCATTGGACTTGGTCACAGGTCCAGTTCTACCTCCAGTTG TCACTGCTTGTCTTTGAGACTGTGGGGTATATCCCTGCTTTATCTGCCACCTTTTTAACT GAGTACCATGGCCCAGCAGTATGAAATTGTTCAGTTCTTCCCAAACTTGAATGTTGGAGC TCATGGTTCGTGTGGTCACTCGCCTCTTGATACCTCAGTATCCTGGAGCTGTGTGTGTCT CAAGTCAGTACTGTTGGCATCATGAGAGAGCAGCCTCAGACAGGCTTGTATGGGTAAAGT TTTGAGTTATGCCATCAGCTCAGAGAAGTATTACTCACCAATGCTGGAGTTTTAAGTAAT TTTTACTTAATTTCCCAAATGTATAGCCAAGGGTTAACATTTGTTTGTTACAGAGAAAAA TGAGTCAGTGACTTGTTTCCATGTGTAGAAGCTGAGGTTCAGGGATGCATAGACAGCAGT AGCTCAGATGCCACGGTAAATCAGAACCCAGGACCCAGGTCTCCTTCTCTTGCTGCCACA AGAGTGCTCTTTGCACAGCACCATATGAGTGTGGCAGTCCTCCTTTTGATGCTGTAGAGT CACAATGGATTTTGGTTGGGGGCAAGGGAGTGTTGATGGCAGCACGGTTCTTCATTGATG GGCAAGGTGGCGACGGTCGCGGAGTGCCTGAATCTGCTCCTGAGCGGAGGGCCTGGGGCA CACCACGCATCGGCTCTTGTCTTCAGTGAGGCAGTGCTCACCCTGTTTCTTCCCCAGTGT GAAGTCCCGCAGTTATCACTGGCAATCTTCCGTCGTAAAAGTACTTGAAGTCATGGAGAA TTTGAAAGAATGCGTAGTTTTTAGTGAGTGACGTGCGCATTTCCAGTCCTGCTACCCTGA AACCTTTGATAAAGTATTTAGTCCAATATTTTTGTTTCCTCACCTACAAAGTGGAGTTAA TGTGATGATACATGTGTGAGAGTGTTTGGGGCCAAGGGGCTGTGGAAAGTGCTGTGTAGA TGTGAAATAAGTATCAATGCTGCTCTGTGAGATAAATCATTCCGGGCCACTTTAAACATA ATCTTCCATCCCTAGCCTATATTGGAGTGAAGAATAGTGTGTATTCTAAGAATGTGTGTA AACTGGTTTGTTGTGTTAAACAAGAATTACACTGACCCACTGAATAAACAAGGACAGTGC TCTGTGCCATTGCGTTGAGATAGCTGTAACGGGGAAAGGCCAGGCTTTCTCCAAAAGCTG CAGGAATCAGCCTGGAGTTAAAGCCTTCTGGTTTGAAATCCAGAAAAGACGAACATCAGA TCAGACCTCTGTATGTGAGGAGCCTGGCTTCCAGAAGAATGCATGATTTGCATGCTTTTG TCGGGGGTGGTGGGTAGGTTGGGGGGACCTAGTCTAGTTTTAATGACTGGAGGATTTTAG CATTTTGTTGCAGTCAAGTAAGTGCTAGGCAGATTCTGTACACTCAACTTAGGGAAGTAA AAATACTGCTTATTAAAAACAACCACGAACCCAGCATTGAGCTAGAAGCACAGCAGCTCC ATTTCACCCTCAGGGTGACTGTGCCCGTGGGCATGCTCACGTAGCTACAGTTGCCCTGGA GCACTGCTGACTAGTGGGCCCAGGTGAACACGTCCTCGGGTCTATCATTTGCAGAAACCT GGGTTCTTTCTCTTTTGTTTTGTTTTGTTTTGTTTTGTTTCATTTTGTTTTGTTTTGTTT TTGAGACGGAGTTTTGCTCTCGTCACCCAGGCTGGAGTCCAATGGCACCATCTTGGCTCA CCGCAACCTCCGCCTCCCAGGTTCAAGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGG GATTACAGGCATGTGCCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTT CTCCTTGTTGATTAGGGTGGTCTCGAACTCCCAACCTCAGGTGATCCGCCTGCCTCAGCC TCCCAAAGTGCTAGGATTACAGACATGAGCCACCTTGGTTCTTTCGAGCTTGTCCGTTTC CTGCTGCTATTTCCCTGCTTGCTCATAGCAAGCGGGAGCTTTGCAATGTGGGCCTGAGTC CTGGGCTTGGGAGGGTCATTTAAGAGACGGTGGAGCTCACCCTTTCCAGGGCCAGCCCGA CGTGGTGCCTCGCTCTGAAGTGCACCTGTTGCCTACGCTGGTTGCTGAGCCACTCGGAGG AAGATATGGGAAGGTAAAAGTGCATCTCCTGGTTGTGCCCTCAGGCATCTATCGAGCTGT GCCTATTCGAGTCAATCCAAGAGTGAGTAATGTGAAGTCTGTCTACAAAACCCACATTGA TGTCATTCATTATCGGAAAACGGATGCAAAACGTCTGCATGGCCTTGATGAAGAAGCAGA ACAGAAACTTTTTTCAGAGAAACGTGTGGAATTGCTTAAGGAACTTTCCAGGAAACCAGA CATTTATGAGAGGCTTGCTTCAGCCTTGGCTCCAAGCATTTATGAACATGAAGATATAAA GAAGGTAACAGTGGATTTTAAACTAGGGGTTGGGATTTACAATTCTTTGGGATCAAATAG TATAAACATCCACTCCGCCACTCGAGCCATCCGCCATAAAGGACAGAGTTGTGGCCTGTT AGAGCAAGTGCTGGCAACCTGACTTGCCATTGGTTGAGAAGAATCATAGCATTGTCTATC CTCATCTCTGGTCTAAACTTAGGTTTCTAAACAGAAGAGGCCACACAGTGTCAGAATAGG GACTTGCATGGCCACCATTCTGGTGTAATGATAGGTGCTGATGAACTGGTCAGTGATAAC TTAAAGCATATCAAGCACTTTCACGAGCCTTTTTATACCTTCCTGTGATTTCTTAATTGT AGTTCTTTATAAGAGAGAAAAGTACCTCTAAAGTTTAAACTACATCTCAGTTAACTGTGC AGAAAATGAATGTTTAGACATGTCTCTGATTATTTAGGGAATTTTGCTTCAGCTCTTTGG CGGGACAAGGAAGGATTTTAGTCACACTGGAAGGGGCAAATTTCGGGCTGAGATCAACAT CTTGCTGTGTGGCGACCCTGGTACCAGCAAGTCCCAGCTGCTGCAGTACGTGTACAACCT CGTCCCCAGGGGCCAGTACACGTCTGGGAAGGGCTCCAGTGCAGTTGGCCTCACTGCGTA CGTAATGAAAGACCCTGAGACAAGGCAGCTGGTCCTGCAGACAGGTGCTCTTGTCCTGAG TGACAACGGCATCTGCTGTATCGATGAGTTCGACAAGATGAATGAAAGTACAAGATCGGT ATTGCATGAAGTCATGGAACAGCAGACTCTGTCCATTGCAAAGGTGAGTCGCCTTCTCCA CCGTGAACATGGACGTGTTTAAAATATGTGGACCCTTGAAAGACAGGGTCTGTGGAACTG TGCTGTGCTACCTTGGTTCTAACTTGGGGAGATTGATAAGTGCTTTCCACATCATATTTC AGCTAAATCTCAACATGTCTTCTACAGGGTGTCACGTTTTGTCTTTATTGCTGTACTAGC CTTGAATTTGTCCTAAAGCTCTTGCAAGGTGCCTGCTTCCTGAGAAAGATGTGGTTATAG CACACATTCATCTAAACTCAGTCCTTGGCATGAATCTGAGGACAGGGCTTATCCAGGTGA ACTGCTGAAGTCAGTAAAGGCAACATGGCTCAGGCAATAGAAACTCAGTGGAGGGAATAT GGGTTTAGTAGGTGGCCGGGCGAAGACGGTGCTTGTTAATTGCCAGCGTCAGGGAGAGGC TTCTAACTGCACTCTTTGCTCTGATAGGCTGGGATCATCTGTCAGCTCAATGCGCGCACC TCTGTCCTGGCAGCAGCAAATCCCATTGAGTCTCAGTGGAATCCTAAAAAAACAACCATT GAAAACATCCAGCTGCCTCATACTTTATTATCAAGGTATTAAAACAGATTTTTATTTTGT TCATTTGTAGAATATTCAGGGTGAGATTGAAAAGGAGCTACTAAGATTTCAGCAACTGCT AATGGAAACTCTTCACTCTTATCAAGATGTTTCAAATTTGGTTGGTCAAGAGTTTTCACG ACAAGGATGATGTGTGTTCTCATTTGTTTTTTAAGCAGTTGGGATGTTTACCTCCCACGC CGTTTACACATGGCTGTCACTCACTACTCTTAGTCCTAAAGCCACTGCTGAGAGTCAACA GAGAACAATTCCGTACAGTAGATGAGGCTCTGAAAAGTTAGATTTATTAAAGTGCAATCA CATAATCTTCACTCTTGGCCCCACTACAAATATTGGACATTTTTCATAAATGGATTTTAG GTTTTAATTACTTGCTTTTTTTTCTTTTTTTTTGACAGAAGTTTTTTTTCCCAAAAAAAC AGTTGAATGTGTTTTCATTCAAATCTTTCCATTGTCAGCCAGGTACAGTGACTCACACCT GTAATTCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCGCCTGAGCTCAGGAGTTTGAGG CCACCCTGGGCAACTTGATGAAACCCCATCTCTACTAAAATACAAAAAATTAGCCCGGCG TGGCGGCGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGAGGCACAAGAATTGCTT GAGCCTGGGGGAGTGGAGATTGCAGTGAGCTGAGATCATACCACTTCACTCTAGCTTGGG CTACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAACTTTCCATCGTCAAAA TTATAGTAACGTTTCCCTAAGGGAAGACTTCCTTTGACTCAGCTGATTGGTCCCCAGCCG TTCCCTGGGCCGACCTAAGGACTAGGGACAGCACAGGGTGAGTGGGGTGAGTGGATGGAC ACGAAGGCCCTTTCCACACCAGGCAAAGATGCTTCTCCCTGATGGCGCTCACAGGGTGCA CATTGACTGCACATCTGTGGTGCTCAAGCAGTCTTTAGTACGTCGTTTGTAGGTGTATTG GTGTCTCAACTAGGAAAACAGTTTTTTTGTTGTTGTTTTGGGTTTTTTTGTTTGTTTTTT TGAGACAGAGTCTCCCTCTGTCGGCCAGGCTGGAGTGCAGTGACGCGAACTTGGCTCACC GCAACCTTCGCCTTCCAGGTTCAAGCGATTCTCCTGCTTCAGCCTCCCAAGTAGCTGGGA TTACAGGCAGGCACCACCACTCCTGGCTAATTGTTGCATTTTTAGTAGAGACAAGGTTTC ACCGTGTTGGCCAGGCTGGTCTCAAACTACCAACCTCAGGTGATCCACCTGCCTCGGCCT CACAAGGTGCTGGAAAAACAGTATTTTTACTTTGTTTTCTTAGGTTTGATTTGATCTTCC TCTTGCTGGACCCTCAGGACGAAGCCTATGACAGGCGTCTGGCTCACCACCTGGTCGCAC TGTACTACCAGAGCGAGGAGCAGGCAGAGGAGGAGCTCCTGGACATGGCGGTGCTAAAGG ACTACATTGCCTACGCGCACAGCACCATCATGCCGCGGCTAAGTGAGGAAGCCAGCCAGG CTCTCATCGAGGTAACCCTGCTGAAAAAAGGCTTACTGTGCCTGTAGCCCACAGCATTAA TGTAACTGACCAATCATCTCCTTTAAAATATTAATTATTTTGTTACGAATAACATACTGT TCTCTTCCTTGTTTTGAGACAGAGCCTGGCTCTCTTGCCCAGGCTGGAGTGCAGTGGCTT GATCTCGGCTTACTGCAGCCTGTGGCCTGTGCTTCTGGGTTCAAGCGATTCTCCTGCTTC AGCCTCCCTATTAGCTGGGATTACAGGTGCCCACAACCACTCCGGCTAATTTTTGTATTT TTAGTAGAGACAGAGTTTCACCGTGTTGGCCAGGCTGGTCTTGAAATCCTGACCTCAAGT GATGCGCCAGCCTCTGCCTCCCAAAGTGTTAGGATTGCAGGCGCAAGCCACCATGCTGGG CCTAAGAATAATAAACTTTTCTTTTTTTTTTTTTTGTGAGACGGAGTCTCGCTGTGTCCC CCAGGCTGGACTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCACCTCCCGGATTCAC GCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACCCACCACCACGCCT GGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGGATGGTCTCGATC TCCTGACCTCGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGC CACCGCGCCTAGCAATATACTATTTTTTATAACTGTTTATTACTTCCTCCCATATTGCAA AATTGATCTTTCCAAATGTTGCAAAAGGGGGAAATAGTTCATTTATGTAGGTAGTACACA CACTTTATATGTTTAAGTACTTACAAGCATAGTGAATTTAAGATCAAAGACCTGGTTTCA AATAGAGGCAACACTACACAGTAATTTGGAAACTGAAAAAGTCATCCAGTTTCTGTAAGC TTCCTTTTGCTTGTAAAAAACAGAATGAGCTGTCTTTTAGGTTCACTTTTCAGCATCCTG GTACATGAGCTGAAGTGCATGATGGCACATTTAGGTTATTCAAGCATTGTGATATTAAGA AGGTTCCTGGTGCTTTGATGAGCTTTGCATCCTAACTGAGCTCCTAAAAATTCTAAGATG AAAGTTACAGACATTATGTAATTTTTTTGTGTGTCATAGTCTTGGGGGTTGTTAATGAAG AAATAAGACTGTGTCATCTGTATGTGAAATTGATACAACTTACCTTTGCAGCATTCTCCC AGCAATCCTTATGAGCCCCATTGTGCCCCATGTGAGCACTTTTCCCAGACAGGCCTGATT CTCCCTATGAGTGCTCACAGCCTTCTCCTCTCCCCACATGCCACATTCCTTCCCTCTGCC ACGCCATGCCCGTCTCTGTTCTTCAGAGCTACGTTAGATGCCACCCTCTCCAAGAATTCT TCCCAAGCATCTCCCAGTTGGAATATGTTCACCCACCACTGCACGCTGCACGTTGATGTC TTCACCTGCGATTTCTGTGGTCTGTCTGTGTAGTCTCTACCACTTGATGAGCTCCGGGGC CCAGGACCATATCTGAGTTCCGTTTACTTAATGGAAGCCTAAGTGTTCAAAATTCACCCA CAAAACTAAAGTTGTCACCAAGGAGGTTTGCTTTTGCTTTTGTTTTTCTACCTACAATAG GCTTATGTAGACATGAGGAAGATTGGCAGTAGCCGGGGAATGGTTTCTGCATACCCTCGA CAGCTAGAGTCATTAATCCGCTTAGCAGAAGCCCATGCTAAAGTAAGATTGTCTAACAAA GTTGAAGCCATTGATGTGGAAGAGGCCAAACGCCTCCATCGGGAAGCTCTGAAGCAGTCT GCAACTGATCCCCGGACTGGCATCGTGGACATATCTATTCTTACTACGGGTTCGTTATTT TCAGTGAACAGAAAAGCTTTTGAAAATTATTTCAATATGCATGTAGTTTATATGTCAGAT TTAAGCTAACAGTTAAATCATTTGAAACAGAAGTTCTTAACCTTTTTTGGATTAGGACCC CTTTGAGAATCTGATGAAAGTTGCCCTTTAATCTTATCTTGATAAAAATATTGATTAACA CACACAGTTTTGTGTATAGTTTTTTTTTGTTTTTTTTTTTTATACTTTAAGTTTTAGGGT ACATGTGCACAACGTGCAGTTTAGTTACATATGTACGCATGTGCCATGTTGGTGTGCTGT ACCCAGTAACTCGTCATTTAACATTACGTGTATCTCCAAATGCTATCCCTCCCCCCTCCC CCCACCCCACAACAGGCCCTGGTGTGTGATGTTCCCCTTCCTGTGTCCGTGTGTTCTCAT TGTTCAATTCCAGTTTTGTGTATAGTTTTAAGGAGATTCTGTCTCCTTGACTGTCTGGGA AGTTTTGTTAACCCATTTTAGAGAAGTTGTTTGTTTCTTAGCAGCAGCTGCTTGCTGCAC AGATGTGTAGACTGTTAAGGAAAGCAGCAGCTAGTGGCTTACAGAAATTTCCAAATAATT AAAAACTCATTCCCTTCAAATGTACTCAGCCCCTGTCGCCTTATCTTTCTAGGTGATACT ACTAAAGGAATATTTTTGAGAATTTGAAGCATTTCATTTCATAATAGCAAAAATGTTTTC ATTGATTTCTTTTTAAATCAGGGATGAGTGCCACCTCTCGTAAACGGAAAGAAGAATTAG CTGAAGCATTGAAAAAGCTTATTTTATCTAAGGGCAAAACACCAGCTCTAAAATACCAGC AACTTTTTGAAGATATTCGGGGACAATCTGACATAGTAAGTGTTTATATGTATTTTTTGT TTGATAGAGCTTTCTCTTTTTCCTTAATATTGCTTTTGGGTTTTTTTCCTTTATTTATTA AATAATAAATATAGAGAAGAATGAAGAAAAGGAAGATGAACCATAAGCCATCATCAAGAA ATAATCACAATTAAAATTTTTGGCTGGGTGCAGTAGCTCACGCCTGTAATCTCATTTGGG ACGCTGAGGTGGGCAGATCACTTGCAGCCAGGAGTTTGAAACCAGCCTGACCAATATGGT GAAACCCTGTCTCTATTAAAAATACAAAAATTAGCTGGATGTGGTGATAAGCACCTGAAA TCCTAGCTACTCAGGAGGCTTAGGCAGGAGAATTGCTTGAACCTGGGAGGCGGAGGTTGC AGTAAGCTGAGATCCCACCATTGCTCTCCAGCCTGGGCACCAGAGCGGAACTCCATCTCA AAAAAAAAAAAAAAGAAAAAATTGTTATGCCCCTTTCATAGTTGTTATAAGTTTGCTTTA GGTATGAAATATTTGGGTGTCCTTTTGTAAATAAGTAAGGTAGTTGTTTAGTGAAAAGAA CTATGCAGTCTTTCAGTGCTGGTCCACTTTCCATCGCTGTGTTGTGACTGAGAGGGCAGA GTTGATAGTTACAACGTGGACTATACAGATGCCAAGTCTACCACATGGACCATCTGGCTA CTCCACTCCTGATTTAGAGCATAAGGCATGTGTACAGCCACCAAAAAGAGAAAGATTCTG GGTGGTACTTTAACATTATAATTATTGTGTTTCTAACAGGTAAAGGAGGGACTTGACGTG TACAATATTTATTTTCTTTCTCTTCCCCACAGGCAATTACTAAAGATATGTTTGAAGAAG CACTGCGTGCCCTGGCAGATGATGATTTCCTGACAGTGACTGGGAAGACCGTGCGCTTGC TCTGAAGCCTTGTGAGCAAGGAAGGCTCCCTGCATGTCCTGCTTGCTGCACGCCACATGG GTGTGGTCTGCATCTCAGTTGGCCGCCATCAGTGTAAATAGAGCTTAAAGTCATGGTTTG GCTGCATAAAAATTTTCTAACTTGGGTTCAATATTTGTAGTGAAGTATCTGTTTTCATTT TTTTCACGTTATAAATAAAAATACTATGCTGGCCGGGCGCGGTGGCTCACACCTGTAATC CCAGCACTTTGGGAGGCCAATGTGGGTGGATCATGAGGTCAGGAGTTCAAGACCAGCCTA GCCAAGATGGTGAAACCCCGTCTCTAGTAAAGATAACAAAAAATTAGCTGGGCTTGATGG CATGCGCCTGTAATCCCAGCTACTCGGGAGGTTGAGGCAGGAGAATCGCTTAAACCCAGG CGGCAGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTCAGCAATAGAGTG AGACTGTCTCAAAAAAAAAAAAAAAAAAAAAACCTGCCAATTTTCAAACATACCGTAGAG ATTATTTTCAGGTGCCATTTTATAGTATAGCAGCAGGGCTTTTACTCTGTGTATGCACAG ATGCAGTCTGGGGCATGGTTTGTGTGCTGGACTTTCTCATGGCCATCATCAGTATGCTTA TGGATTTGATGACAGGCATAGCCTGGGCATATCACCTCATTGGTAAAGGGCTAGAGCCTT TCTTTTTTATGGCAC OMIM ID 602638