Entrez gene ID | | 4522 |
Official gene symbol | | MTHFD1 |
Full name | | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase |
Aliases | | ,MTHFC,MTHFD, |
Gene summary | | This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. [provided by RefSeq] |
Location | | Chromosome: 14 Locus: 14q24 |
Gene position | | 64854759 - 64926725 Map Viewer |
Gene orientation | | plus |
Gene size | | 71967 bp |
Gene sequence |
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OMIM ID | | 172460 |
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