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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for NFKBIA (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 4792 Official gene symbol NFKBIA Full name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Aliases ,IKBA,MAD-3,NFKBI, Gene summary NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM] Location Chromosome: 14   Locus: 14q13 Gene position 35873960 - 35870716  Map Viewer Gene orientation minus Gene size 3245 bp Gene sequence >NFKBIA:complement(16870716..16873960):Length=3245 AGCCCACAGCAGTCCGTGCCGCCGTCCCGCCCGCCAGCGCCCCAGCGAGGAAGCAGCGCG CAGCCCGCGGCCCAGCGCACCCGCAGCAGCGCCCGCAGCTCGTCCGCGCCATGTTCCAGG CGGCCGAGCGCCCCCAGGAGTGGGCCATGGAGGGCCCCCGCGACGGGCTGAAGAAGGAGC GGCTACTGGACGACCGCCACGACAGCGGCCTGGACTCCATGAAAGACGAGGAGTACGAGC AGATGGTCAAGGAGCTGCAGGAGATCCGCCTCGAGCCGCAGGAGGTGCCGCGCGGCTCGG AGCCCTGGAAGCAGCAGCTCACCGAGGACGGGGACTCGTAAGTGGCGGAGGCCCGGGGCT GGGGGTCGTCGGGAGGGCGGGACGCGCGCGGCCTGGGGGTGGGAGGCGCCGGGCCTGGAG CCCGAGCCGGGGGACCAGCGATGCAGCCGGGCGGGCGCCGCGGCACCCCGGGGCTCCTGC ACCGCCCCGAACGCTGCAGGGCTGCAGGGCCGCGCGGGGCACCGGCCCAACTCGGAGGGG CGGCGGCTGGGCCCTGGTGGATGGCAGCGTCGCCACACGCCCCCTCCCCCCAGACCCGTC CTCTAGGCCGGGGGCGGGGCGGCAGCGGGGACGCGAAGTCCCCGGTTGCATAAGGCGGGG CGGGAGTTTCTGGCCGCTGGCGGGCGCCGAGCAGCCGGGAGGGGAAGTACAGGGCGTTCC GAGCTGGCGGGAGGGCGGGGCGGTCTGGCCGGCGCCCGCCGGGGCCGCGGGGGGAGGGGG GCGGAAAGTCCCTGGGCGCCTGCCAGGAACACTCAGCTCATAATAACCTCGCGGAAAACA CCGCGGCCTCGGCCTCCAGAAACCCCGGCCTTGCGCAATCCCCCGCAGCCCGCGCCTCCC TGGGCCCCACGCGGTGCACTCACCACCCCTGGGGTTTTTCCCTCTCTTCCCCACAGGTTC CTGCACTTGGCCATCATCCATGAAGAAAAGGCACTGACCATGGAAGTGATCCGCCAGGTG AAGGGAGACCTGGCCTTCCTCAACTTCCAGAACAACCTGCAGCAGGTGCGCCGCTTGCCT GGCCCGGGTTCTCTCTGACCCTGGGACGTAGCTGATGTAGCAGAGTCACCCCAGATCCTT TCTGAATTCAGGGCCACTGAGCACTATTTACCCTCACCTTTTACTTCACATCAGCCCACA TCCTAGAGAGTGAAGGAAATTCCACTGATTTGGTGAGGTCTTTATGACCCACCTGGAGCC TCTGCTATTTGCCAGCCCTCCCCACCCCCCTGTCTAGGAGGAGCAGCACCCAACCAGGAG ACACGGGTTGAGGGGAACTCGGGGTGTGGGTTTGGTCCATGGCTTACTTTCTCTGGTCTC TCTTGCATTCGTAGACTCCACTCCACTTGGCTGTGATCACCAACCAGCCAGAAATTGCTG AGGCACTTCTGGGAGCTGGCTGTGATCCTGAGCTCCGAGACTTTCGAGGAAATACCCCCC TACACCTTGCCTGTGAGCAGGGCTGCCTGGCCAGCGTGGGAGTCCTGACTCAGTCCTGCA CCACCCCGCACCTCCACTCCATCCTGAAGGCTACCAACTACAATGGTATGTCTGCCTCCC TGCCCTGCCCCACCCCCTCGGAGGGCAGGTGACGTGGAGAAGGGGCAGGTGGGCCAACTT AAGGAGTCCAGGCAAGAGCTTAAACTCCTAACATTTGGAAGGTTGAGAAAATATGTGTGC AAAGTGCCTATTGGATGCCTTTATAAAGTTCTTTCAGAACCCAGACTGTGGGTTCTTAAA ATTCAGAAGATAAGACTACTTGTTCCATAAAAGAATAGGTGAAAGGAGTGAGGGTTGAAA CAGGTGGTTATACTTTTTTCCTTTTGTTCTTCCAGGCCACACGTGTCTACACTTAGCCTC TATCCATGGCTACCTGGGCATCGTGGAGCTTTTGGTGTCCTTGGGTGCTGATGTCAATGC TCAGGTTGGTGCTTCCTGCCCCCGACGCACTGAGTCAGGCTCCTCGTGCTTATGTTGTGA GCAGAAATTCCAAATGCAGCCATAAGCATCTCAAATTCCTTTTGGTTTCAGGAGCCCTGT AATGGCCGGACTGCCCTTCACCTCGCAGTGGACCTGCAAAATCCTGACCTGGTGTCACTC CTGTTGAAGTGTGGGGCTGATGTCAACAGAGTTACCTACCAGGGCTATTCTCCCTACCAG CTCACCTGGGGCCGCCCAAGCACCCGGATACAGCAGCAGCTGGGCCAGCTGACACTAGAA AACCTTCAGATGCTGCCAGAGAGTGAGGATGAGGAGAGCTATGACACAGAGTCAGAGTTC ACGGAGTTCACAGAGGACGAGGTGAGTCTGTGAACTCCTTCGGCGCTCTAACTAATGAGG TGCCATTCCCTTCACCCTCCCAGGCCCCTAGAGCTGCTCCTTATCAGAGGGGTATCTACA TAATGAGTCTCTCAAATTTCTGTGCATAACCAGTATCCCAAGAATGTACCTGCCCCCCCT CTTTTTTTAAAGAGAAGCATTAAAGGCAAACTCTCTCAGCCTGTAAAGTTCATTATATTT GGGCTATGGAGAATGGAGTCCAAGAGTTATTTCCAGTAGTGGCCTCCCCATCCCGGTAGC TTGGCAGAGCTCCGCTCCGGAAGCTTAACGTGTCTTTTTTCCCCTTGTTTTCAGCTGCCC TATGATGACTGTGTGTTTGGAGGCCAGCGTCTGACGTTATGAGCGCAAAGGGGCTGAAAG AACATGGACTTGTATATTTGTACAAAAAAAAAGTTTTATTTTTCTAAAAAAAGAAAAAAG AAGAAAAAATTTAAAGGGTGTACTTATATCCACACTGCACACTGCCTGGCCCAAAACGTC TTATTGTGGTAGGATCAGCCCTCATTTTGTTGCTTTTGTGAACTTTTTGTAGGGGACGAG AAAGATCATTGAAATTCTGAGAAAACTTCTTTTAAACCTCACCTTTGTGGGGTTTTTGGA GAAGGTTATCAAAAATTTCATGGAAGGACCACATTTTATATTTATTGTGCTTCGAGTGAC TGACCCCAGTGGTATCCTGTGACATGTAACAGCCAGGAGTGTTAAGCGTTCAGTGATGTG GGGTGAAAAGTTACTACCTGTCAAGGTTTGTGTTACCCTCCTGTAAATGGTGTACATAAT GTATTGTTGGTAATTATTTTGGTACTTTTATGATGTATATTTATTAAACAGATTTTTACA AATGA OMIM ID 164008