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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for NFKBIA (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000060 protein import into nucleus, translocation IEA GO:0002224 toll-like receptor signaling pathway TAS GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS GO:0006915 apoptosis TAS GO:0006916 anti-apoptosis TAS GO:0007253 cytoplasmic sequestering of NF-kappaB IMP GO:0008063 Toll signaling pathway TAS GO:0010745 negative regulation of macrophage derived foam cell differentiation IMP GO:0010875 positive regulation of cholesterol efflux IMP GO:0010888 negative regulation of lipid storage IMP GO:0031663 lipopolysaccharide-mediated signaling pathway IEA GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA GO:0032270 positive regulation of cellular protein metabolic process IMP GO:0032495 response to muramyl dipeptide IEA GO:0032496 response to lipopolysaccharide IEA GO:0034130 toll-like receptor 1 signaling pathway TAS GO:0034134 toll-like receptor 2 signaling pathway TAS GO:0034138 toll-like receptor 3 signaling pathway TAS GO:0034142 toll-like receptor 4 signaling pathway TAS GO:0042127 regulation of cell proliferation IEA GO:0042345 regulation of NF-kappaB import into nucleus NAS GO:0042994 cytoplasmic sequestering of transcription factor IDA GO:0043330 response to exogenous dsRNA IEA GO:0043392 negative regulation of DNA binding NAS GO:0044419 interspecies interaction between organisms IEA GO:0045087 innate immune response TAS GO:0045638 negative regulation of myeloid cell differentiation IEA GO:0045746 negative regulation of Notch signaling pathway IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0050852 T cell receptor signaling pathway TAS GO:0051092 positive regulation of NF-kappaB transcription factor activity TAS GO:0070417 cellular response to cold NAS GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway IEA GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IEA cellular_component GO:0005634 nucleus IDA GO:0005737 cytoplasm IDA GO:0005829 cytosol TAS GO:0005886 plasma membrane IDA GO:0033256 I-kappaB/NF-kappaB complex TAS molecular_function GO:0005515 protein binding IPI GO:0008134 transcription factor binding TAS GO:0008139 nuclear localization sequence binding IPI GO:0019899 enzyme binding IPI GO:0031072 heat shock protein binding IEA GO:0031625 ubiquitin protein ligase binding IPI GO:0042802 identical protein binding IPI GO:0051059 NF-kappaB binding IDA GO:0051059 NF-kappaB binding IPI

Protein-protein interaction details for NFKBIA (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID UBE2E3 Two-hybrid physical 9409737 POM121 Two-hybrid physical 16189514 SUMO4 Two-hybrid physical 15247916 SUMO4 Affinity Capture-Western physical 15247916 COMMD1 Affinity Capture-Western physical 14685242 NCOR2 Affinity Capture-Western physical 12589049 PIR Two-hybrid physical 10362352 BARD1 Two-hybrid physical 10362352 RELA Reconstituted Complex physical 11533489 RELA Reconstituted Complex physical 12419806 RELA Reconstituted Complex physical 12419806 MED19 Two-hybrid physical 16169070 CHUK Biochemical Activity physical 9252186 PTPN13 Reconstituted Complex physical 9882613 FBXW11 Affinity Capture-Western physical 10644755 BTRC Affinity Capture-Western physical 10644755 BTRC Reconstituted Complex physical 9990853 RELA Affinity Capture-Western physical 9990853 BTRC Affinity Capture-Western physical 9990853 RELA Affinity Capture-Western physical 9990853 BTRC Affinity Capture-Western physical 9990853 TP53 Affinity Capture-Western physical 11799106 TP53 Two-hybrid physical 11799106 VCP Affinity Capture-Western physical 9452483 VCP Reconstituted Complex physical 9452483 RELA Affinity Capture-Western physical 11313474 NFKB1 Affinity Capture-Western physical 11313474 HNRNPA1 Affinity Capture-Western physical 11313474 HNRNPA1 Affinity Capture-Western physical 11313474 HNRNPA1 Reconstituted Complex physical 11313474 DYNLL1 Two-hybrid physical 9372968 DYNLL1 Reconstituted Complex physical 9372968 DYNLL1 Affinity Capture-Western physical 9372968 RELA Affinity Capture-Western physical 8139561 PIK3R1 Reconstituted Complex physical 9892650 IKBKB Reconstituted Complex physical 9891086 RPS6KA1 Biochemical Activity physical 9214631 RPS6KA1 Affinity Capture-Western physical 9214631 RPS6KA1 Affinity Capture-Western physical 9214631 RELA Reconstituted Complex physical 9738011 NFKB1 Reconstituted Complex physical 9738011 G3BP2 Reconstituted Complex physical 10969074 G3BP2 Affinity Capture-Western physical 10969074 G3BP2 Affinity Capture-Western physical 10969074 REL Affinity Capture-Western physical 10706725 CAPN1 Reconstituted Complex physical 10521480 IKBKB Reconstituted Complex physical 9751059 CHUK Reconstituted Complex physical 9751059 MAP3K14 Reconstituted Complex physical 9751059 RELA Reconstituted Complex physical 9751059 IKBKAP Reconstituted Complex physical 9751059 IKBKB Biochemical Activity physical 9346485 CHUK Biochemical Activity physical 9346485 LYL1 Reconstituted Complex physical 10023675 CHUK Biochemical Activity physical 10094049 HOXB7 Reconstituted Complex physical 10026139 UBE2D1 Two-hybrid physical 9409737 UBC Affinity Capture-Western physical 18503636 AURKA Reconstituted Complex physical 17060341 RELB Affinity Capture-Western physical 19219072 RELA Affinity Capture-Western physical 19219072 PSMA2 Reconstituted Complex physical 16098527 HDAC3 Affinity Capture-Western physical 16371367 RELA Affinity Capture-Western physical 16105840 CHUK Biochemical Activity physical 12054687 IKBKB Biochemical Activity physical 12054687 RELA Affinity Capture-Western physical 7878004 NFKB1 Affinity Capture-Western physical 20980497 RELA Affinity Capture-Western physical 20980497 ABL1 Affinity Capture-Western physical 12167702 ABL1 Reconstituted Complex physical 12167702 NFKB1 Affinity Capture-Western physical 20237821 NCOR1 Affinity Capture-Western physical 15536134 NCOR2 Affinity Capture-Western physical 15536134 HDAC1 Affinity Capture-Western physical 15536134 HDAC2 Affinity Capture-Western physical 15536134 HDAC4 Affinity Capture-Western physical 15536134 HDAC5 Affinity Capture-Western physical 15536134 NCOR2 Affinity Capture-Western physical 15536134 RPS3 Affinity Capture-Western physical 18045535 UBC Reconstituted Complex physical 11950839 UBC Affinity Capture-Western physical 11913973 CUL1 Affinity Capture-Western physical 11483504 UBC Affinity Capture-Western physical 11415944 RELA Affinity Capture-Western physical 11231305 UBC Affinity Capture-Western physical 10968793 CUL1 Affinity Capture-Western physical 10713156 NEDD8 Affinity Capture-Western physical 10713156 SKP1 Affinity Capture-Western physical 10514433 SKP1 Reconstituted Complex physical 10230406 FBXW11 Reconstituted Complex physical 10230406 BTRC Affinity Capture-Western physical 10066435 FBXW11 Affinity Capture-Western physical 10066435 BTRC Affinity Capture-Western physical 10066435 FBXW11 Affinity Capture-Western physical 10066435 SKP1 Affinity Capture-Western physical 10066435 CUL1 Affinity Capture-Western physical 10066435 SUMO1 Affinity Capture-Western physical 9734360 RELA Affinity Capture-Western physical 8887633 RELA Reconstituted Complex physical 8887633 RELA Affinity Capture-Western physical 8978697 UBC Affinity Capture-Western physical 8978697 RELA Affinity Capture-Western physical 7628694 UBC Affinity Capture-Western physical 8631829 NFKB1 Affinity Capture-Western physical 8631829 BTRC Affinity Capture-Western physical 10075690 BTRC Two-hybrid physical 10075690 SLC25A4 Reconstituted Complex physical 11287411 SLC25A4 Affinity Capture-Western physical 11287411 SLC25A4 Affinity Capture-Western physical 11287411 RELA Affinity Capture-Western physical 11287411 RPS6KA1 Biochemical Activity physical 9261139 RPS6KA1 Affinity Capture-Western physical 9261139 RPS6KA1 Affinity Capture-Western physical 9261139 RELA Affinity Capture-Western physical 20065107 BTRC Affinity Capture-Western physical 9859996 RASA1 Phenotypic Suppression genetic 12151397 FBXW11 Reconstituted Complex physical 12165731 UBC Affinity Capture-Western physical 20068069 UBC Affinity Capture-Western physical 20068069 COMMD1 Affinity Capture-Western physical 20068069 CLU Affinity Capture-Western physical 20068069 MALT1 Affinity Capture-Western physical 20551178 BCL10 Affinity Capture-Western physical 20551178 RELA Affinity Capture-Western physical 20551178 CSNK1A1 Affinity Capture-Western physical 20551178 RELA Affinity Capture-Western physical 20551178 BCL10 Affinity Capture-Western physical 20551178 CSNK1A1 Affinity Capture-Western physical 20551178 NFKBIA Biochemical Activity physical 10066434 UBC Affinity Capture-Western physical 10066434 UBC Reconstituted Complex physical 10066434 CHUK Biochemical Activity physical 10066434 RELA Affinity Capture-Western physical 10066434 IKBKG Biochemical Activity physical 21896478 CHUK Biochemical Activity physical 20932476 CDC34 Biochemical Activity physical 20347421 UBC Reconstituted Complex physical 20347421 BTRC Biochemical Activity physical 20353940 UBC Affinity Capture-Western physical 19933270 UBC Reconstituted Complex physical 19933270 BTRC Biochemical Activity physical 19933270 BTRC Affinity Capture-Western physical 19933270 BTRC Reconstituted Complex physical 19933270 UBC Affinity Capture-Western physical 19494296 IKBKB Affinity Capture-Western physical 20797629 IKBKB Affinity Capture-Western physical 20797629 CSNK2B Affinity Capture-Western physical 20797629 RELA Affinity Capture-Western physical 20797629 HNRNPU Affinity Capture-Western physical 20797629 IKBKB Affinity Capture-Western physical 22022389 BTRC Affinity Capture-Western physical 22022389 UBC Affinity Capture-Western physical 22022389 RELA Affinity Capture-Western physical 22022389 SUMO1 Affinity Capture-Western physical 19625650 UBC Affinity Capture-Western physical 20797629 BTRC Affinity Capture-Western physical 20797629 BTRC Affinity Capture-Western physical 20797629 MAPK14 Affinity Capture-Western physical 20797629 MAPK14 Affinity Capture-Western physical 20797629 RELA Affinity Capture-Western physical 22081069 NFKBIB Affinity Capture-Western physical 22081069 RELA Affinity Capture-Western physical 22081069 TRE17 Affinity Capture-Western physical 22081069 IKBKG Affinity Capture-Western physical 22081069 TRE17 Affinity Capture-Western physical 22081069 RELA Biochemical Activity physical 22081069 NFKBIB Biochemical Activity physical 22081069 COPS2 Affinity Capture-Western physical 17318178 UBC Affinity Capture-Western physical 17318178 NFKB1 Affinity Capture-Western physical 20558726 BTRC Affinity Capture-Western physical 20558726 FBXW8 Affinity Capture-Western physical 20558726 UBC Reconstituted Complex physical 10570937