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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for NOTCH3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID4854
Official gene symbolNOTCH3
Full nameNotch homolog 3 (Drosophila)
Aliases,CADASIL,CASIL,
Gene summaryThis gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq]
LocationChromosome: 19   Locus: 19p13.2-p13.1
Gene position15311792 - 15270444  Map Viewer
Gene orientationminus
Gene size41349 bp
Gene sequence
OMIM ID600276