Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for NTRK1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID4914
Official gene symbolNTRK1
Full nameneurotrophic tyrosine kinase, receptor, type 1
Aliases,DKFZp781I14186,MTC,TRK,TRK1,TRKA,Trk-A,p140-TrkA,
Gene summaryThis gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq]
LocationChromosome: 1   Locus: 1q21-q22
Gene position156785542 - 156851642  Map Viewer
Gene orientationplus
Gene size66101 bp
Gene sequence
OMIM ID191315