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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PDGFA (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5154
Official gene symbolPDGFA
Full nameplatelet-derived growth factor alpha polypeptide
Aliases,PDGF-A,PDGF1,
Gene summaryThe protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene. [provided by RefSeq]
LocationChromosome: 7   Locus: 7p22
Gene position559481 - 536895  Map Viewer
Gene orientationminus
Gene size22587 bp
Gene sequence
OMIM ID173430