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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SIRT6 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 51548 Official gene symbol SIRT6 Full name sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) Aliases ,SIR2L6, Gene summary This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants. Location Chromosome: 19   Locus: 19p13.3 Gene position 4182596 - 4174106  Map Viewer Gene orientation minus Gene size 8491 bp Gene sequence >SIRT6:complement(4114106..4122596):Length=8491 GCTTCCGGCGGAAGCGGCCTCAACAAGGGAAACTTTATTGTTCCCGTGGGGCAGTCGAGG ATGTCGGTGAATTACGCGGCGGGGCTGTCGCCGTACGCGGACAAGGGCAAGTGCGGCCTC CCGGAGGTGAGCGCGTCTGAGGGTCCCGAGCATCGCGCCCCAGGGCCGCGGGCTGGGAGC GGCCGGATGGCAGGGGGGCATTGTGGGAATATCAGGGGGCACTGAGGCTAGACAATGGGA GGGACTTCCCAGTGAGGAAGGGGCGGGAAGTGACGCCCCTGCGCGCCGGGGGACGCCAAC ACGCCCAACTCTGTGGTCACCCTGTCGGGGCTGATCGGGGAGAGAGGGGATGTAGTTCCA GGAAGAGGGGACGACAGGCGCAAAGGGAGGTGGGAATAAACACACCTGGAGAACGATTAG GCCTGGGAGGTTTCCAGAGCCGGGCCAGGACGGGGCTCAAATGCCAGGCTGGGGAGTTGG CACTTTATCCTGAGGGTGATGGGGAAGGGTTTTGCCCTGGCGAGGGGACTGGACAGAATG TGCCAGAAAGATCCCTCCAGCCACTCAGAGGGGAAGTGGAGGGATCGGCTGCCCCCTCCA CGCACTGTGGGACTTTGGGGAAGTCACTTCCCTTTTGGGTCTCCATCTCCAAACTTTCTG CAAACGAGGTGAAGATGGCCCCATTCCATAAGGCTGGCCCATGCATTCTGACTCATGCAT TTAATGAGCGCTGATGGTGTGCGCCCGTCCAGAAGCCCCACTCTTCACTGCTGCTGTTAG TCACTTTATTATTATTATTATTATATTTTTGAGATGGAGTTTCTCTGTCGCCCAGGCTGG AGTGCAGTGGCGCGATCTCGGCTCACTGCAACCTCCGCCTCCTAGGTTCAAGCGATTCTC CTGCCTCAGCCTCCTGAGTAGAGTAGATGAGACTACAGGCACCTGCCACCACGCCTGGCT AATTTTTGTATTTTTAGTAGAGGCGGGGTTTCACCATGTTGGCCAGTCTGCTCTTGAACT CTTGATCTCAAGTGATCCACCCACCTTGGCTTCCCAAAGTGCTGGGATTATAGGCGTGAG CCACCATACCCGGCCTGTTAGTCACTTTATTCCACCAACATTTATAGAGCACTTACTGTA GCTCAGGCACTTTCTAGGTACTAAGGCCACAGCCAGGAGCAACACAGATTAAAAACCCCT CCTTCTAGTAAGGGAGACTGACTAGGGGTTGCATGGAAACCAGTTGGCCAAGGGAGGCAT CACTGTCACTGAAGTGACATCTAAGCCACAAGTTACAGGAGGTGAGGGAGGGAGCCATGT GGGTATCTGGGGGAAGAGCATTAAAGGGTGTGGCCCTGAGGCGGGACTGTGCCTGGTGTG ATAGAGGAACAAGGAGGAGACCTGTGTGGCTGGAGCAGAGTGAGGCAGGGAGAGGGAGGA GAAGAGGGCAGGGAGGGGGCAAGGGAGGTAGTGCAGGGCCTGGTGGGCCGTGGGAAGGGC TAGGGCTTTGACAAGGCAGGTGGGAGGCATGGAAGGTTGTAGGAAGAGGAGGGGCATGAG GACAAGCTGCCTTTTCCAATCCATTTTCCTCCCTCAGGCAAGACAGGGACAGCTCAGTCT GTGGCTCGTGCGTGGCCTTGCCACTTGGGGGAACTGTTTTGACCCCTCCGTCTGCTCTCT CCCCCCACAGATCTTCGACCCCCCGGAGGAGCTGGAGCGGAAGGTGTGGGAACTGGCGAG GCTGGTCTGGCAGTCTTCCAGTGTGGTGTTCCACACGGGTGCCGGCATCAGCACTGCCTC TGGCATCCCCGACTTCAGGTCTGTGATTGTGCAGGGGAAGTCGAGGCAAGGCCTACCAGG CTGCCAGAGGCTTCCCTGCGAGCCACACACATCTGGGAATGAGAACACATCCATCTGCTT TCCTCCTGGATGTGTCCTGGGTACTCCCTTTAAGATGTGTCCCTTGGCTGGGCATGGTGG ATCACAAGGTCAAGAATTCCAGACCAGCCTGGCCAATATGGTGAATCCCTGTCTCTACTA AAAATACAAAAATTAGCCAGTTGTGGTGGCACACATCTGTAGTCCCAGCTACTCGGGAGG CTGAGGCAGGAGAATTGCTTGAACCTGGGAGGTGGAGGCAGTGAGCCGAGATTGCACCAC TGCACTCCAGCCTGGGCGACAGAGTGAGGCTCCGTCTAAAAACAAAACAAAAAGATGTGT CCCTTGTCACAACCAGCATTCCACTCACCTCATTGGCCAGAACACGGTCACCTGATCACA CCTGGCTGCAAGGGTTGCTGGGAAATGTAGTCTTTCATATTTGCAAGCGTAGCCAGGTGT GGTGGCAGGCACCTGTAATCGCAGCTACTTGGAAGGCCGAGGTGGGAGAATCGCTTGAAC CCGGGAGGCAGAGGTTGCAGTCAGCCAGGATCATGCCATTGTACTCCAGCCTGGGCAACA GAGCCAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGCCAAGGCGTGAAT TTCTCCTCCTTCTCCTCTTCCATAACCTGCTGTGGCTCCCCATTGCCAGGCAGTGTAGAG TTCTGAATACCTTGTGCTGGAAGCTGAAGCCCTTCCTGCCCCAGCCCTGAATCACCTCTC CAACTTCAGCCCCTCCTGCTCCTGCTGCAGCCCCCAAAACACTTGCATTTTCTCCTAAAC TCATGGGCTCTTCCCAGCACCCAGGCCTTTGTTTACCCCTTCTGTCTGATCTTCCCTCTC ACCCTTCAAGAAACTGCTTAGCCTCCTCCAGGAAGCCCTTCCACGTGCCCCAGGGCCCCC ACCTCCACGGGGCTTCCCCAGGCCCAGGTACCTCCTCTGATCCAGGCTTGACTCTTGGGG CCAGAGGATCTGTGTCCACCTGTCTCCCCCAAGATCAAGGGCTTCTGGAGGGCAGGGCTT GGGCCCATGTGAGCATCGTCGGGCTCATTGCAGCAGCAGTGTTGGTTGAATAGAATAAGT CATTTTTGCCTTCGTGTGAATTCATCTCTCTCTCTCTGCCTCTCCCTCTCTCTGTCTCTC TCCAATTCTGTCTCTGACTTGCTTTGTCTTTAACTCTTTATCTCTCTGTCTGTGTCTTGT TCTATCCCCCTCTCCCTGTTCTTGCAACTCACCCTCTATTTCTGTTTCTGATTCCCTCTC TCTGTCTCCCTGTCTCTCTCTGTCTCCTGATTTTCTCTCTCTCCAACTTTCTCTCTATAC CTCTCTGATTCTCCCTCTGTCTCTTTTTCTGTTCCCCTCTCCCCGTCCATCTCTCCCGGC CTGCCACCTTCAGGGGTCCCCACGGAGTCTGGACCATGGAGGAGCGAGGTCTGGCCCCCA AGTTCGACACCACCTTTGAGAGCGCGCGGCCCACGCAGACCCACATGGCGCTGGTGCAGC TGGAGCGCGTGGGCCTCCTCCGCTTCCTGGTCAGCCAGAACGTGGACGGGCTCCATGTGC GCTCAGGCTTCCCCAGGTAACACCCTGGCCCCGCCCCCACAAAAGAGCTTGGGGCCCCAC AAACCGTGTTTGCATTTTTAGGGGGAGAGTCCCCTTTTCCTGGTTCTATAAGATTCTAGC CCTGAGTTCTTGGCCCAGTGTGTGGAGATCTCTGAGTCCCATGGCTCAGAGCTGTCCCGG CTGAGGCCAGAGGCAGAATTTCCCTCGAGATGGGGCTAAGGGGAGGAGAGCTGTCAGGGT CTAGAAGTTGCAGTTTGTTTTTTGTTGTTGTTGTTGTTTTTGAGACCGAGTTTCGTTCTT GTTGCCCAGGCTGGAGTGCAATGGCGTGATCTCCGCTCAGCCTCCCAGGTTCAAGCGATT CTCCTGCCTCAGCCTCCCTAGTAACTGGGATTACAGGCATGCGCCATCACACCCAGCTAA TTTTGTATTTTTAGTAGAGACGGGGTTTCTCCATGTTGGCCAGGCTGGTCTTGAACTCCT GACCTCAGGTGATCTGCCCGCCTCAGCCTCCCAAAGTGCTGGGGTTACAGGTGTGAGCCA CCACGCTTGGCCTGTTGTGTTTTTAATATCCATCTTTATTAATCTGACACTAAACGTGTC TGACACTGAAGTGAACCTGTGCTCTGGGGCAGGCTGATTTCCCAATAAAAGTGTGGCCCT CCCCTGCCCCTCTTTGCCAGGTCTCACCCCTGGGGCAACCAATGACAGCCAGGTCAGTTG TTGAGACGAGGAGCTCGGCAGCCAGGGGTGAGGGGTGAGGAAGAGATTTTTCTCTGCTTA TAAAAGCAAACGAGGGGCCGGGCATGGTGGCTCACATCTGTAATCCCAGCACTTTGGGAG GCCGAGGCAGGCGGATCACGAGGTCAAGAGTTCGAGACCAGCCTGGCCAACATGTTGAAA CCCCATCTCTACTAAGAGTACAAAAATTAGCTGGGCGTGGTGGCGCATGCCTGTAATCCC AGCTACTCGGGAGGCTGAGTCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTG AGCCGAGATGGCGCCACTGCACTCCAGCTTGGGTGACAGAGCAAGACTCTGTCTTGAAAA AAAAAAAAGCAAAGGAGGGTCAGGTGTGGTGACTTATGCCTGGAATCTCAGCACTTTGGG AGGCCAAGGCGGGCGGATCATGAGGTCAGGAGATCGAGACCATCCCGGCCACATGGTAAA ACCCCGTCTCTACTAAAAACAGAAAAATTAGGCTGGGTACAGTGGCTCACGCCTGTAATC CCGGCACTTTGGGAGGCCGAGGCGGGTGGATCACAAGCTCAGGAGATCGAGACCATCCTG GCTAACACGGTGAAACCCTGTCTCTACTAAAAATACAAAAAATTAGCCCGGCGTGGTGGC GGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCCGGA GGCAGAGGTTGTGGTGAGCTGAGATTGTGCCATTGAGGTTGTGGTGAGCTGAGATTGCAC CATTGCACTCCAACCTGGGCAACAAGAGCAAAACTCTGTCTCAAAATAAATAAATAAATA AAATAAAGCTGGGATTGGATCTCATGCTTCAGGGCCATTCAATGTCTCGGTTTCTTCCAT TATAAACTGGGAATTTGAATTCCTGTGCTTCTGACCTGGTGACATCAAGAGGTTCCCATA TGCTCTCGGAGGGGGACGGGCATTTTGTGAGTGGAAAGGGCTTCCCGTTATCTAAGGTGG GTTCAGCCTTGGGGGTTAATGATTCCTTGGGCTCAGAGAGGTTGGTCCACTTGCCCAGAG ATGCACAGCAGATGAATGGTGGAGCCAGGAGCTAGAAGAGCCAGAAAGAAGGAGTTGATC AATGTTGTGGGAGAGGAGTCCGGGAAGCCTTCCTGGAGGAGAGGGGCTTAGCACCAGCTC CAAAGCCTGGGCATCCAGGGATCCTTTCCCACCATCAAGCCTCTTCCTGCTCTTCCCACA GGGACAAACTGGCAGAGCTCCACGGGAACATGTTTGTGGAAGAATGTGCCAAGTGTAAGA CGTGAGTGCCACCTGGGTGCAGGGGTGGGGGCTCTGCCAGAGGGGGTTGGGGGTCGAATC CGATGTCCCAGAGACCCAGAGGGTATGGGGGGACTGGGGTGTGGCCCTCCTGGGGGGATC TGGGGGCGTGTCTCCCTCTTGGGGGGATATAAGGAGTATGTCTCCCTCCTGGAGGGATTT GGGGGGCATGTCTTCCTCCTGGAGGGATTTGGGGGGGCCGTGCCTCCCTCCTGTGGGGGG TACATCCGTGTCCTGGCACTGCTGTAGCAACCTGCCACAGATGAGCAGCGTAGAACAATA GAAATTTGTGATCTCACAGTTCTGGGGACCAGAAGTCCAAAATCCAGGTGTCTGCAGGGC CATGCCCCTCTGCAACCTGTAGGGGAGGATTTTTCCTGCCTTTTCCTGGCTGCTGGTGGC AGCCAGCCACCCTTGGTGGTCCTGGACCTACAGCCACAGGGGCCTTCTTATCTCTGTGTT TCTCCTTTTTTTTGAGACAGTCCCGCTCTGTCATCCAGGCTGGAGTACAGTGGGGCAATC TCGGCTCACTGCAACCTCCGCCTCCCGGGTTCAGGCAATTATTCTGCCTCAGCCATCCAA GTAGCTGCAACTGCAGGCGCCCGCCACCACACCTGGCTAATATTTGTATTTTTAGTAGAG ACGGGGTTTCACCATATTGGCCAGGCTGGTGTCGAACTCCTGACCTTGTGATCTGCCCGC CTCAGCCTCCCAAAGTGCTGGGATGACAGGCGTGAGCCACCACGCCCGGCCCAGTATAAC GATTAAAGTCAGGAAAAGTAAAGTGGACATCGCCTTCTCTAATCCCGAATCCAGACTCGG CCTGTCGCCCCCATGCTCCAATTGTTCCTGTTTCTCCTGGTCCGGGATCCCATGCTGGGT CTTGTCTCTCGAGCCCCTTCGTCTGTCTGGGACAGTTTCCTGCTTTGTTTTCTGTGCTCC GGGCACCGAGCAGCATCCCAGCCCGTTATTCATGGAAGGCTACTCGTTCCGTGTCGCTGG GTGCTAGTTCTGGTCACCTGTCCACCCCCCACCTCCCTGGGAGAACGTCACCCTAGAAAC AGTGCGAGAGTCACCCATGGGAGCTCACCTGGTCCCATCCTCCCCCTTCCTCCCTGACAC AGGCAGTACGTCCGAGACACAGTCGTGGGCACCATGGGCCTGAAGGCCACGGGCCGGCTC TGCACCGTGGCTAAGGCAAGGGGGCTGCGAGCCTGCAGGTGAGCCACCCCCACCCATGCC CTGGGCTCCAGGGGAGGCTGCGAGGCCCCTGAGGACTCTCCTCAGCTTCCTCATTGCAGG GGAGAGCTGAGGGACACCATCCTAGACTGGGAGGACTCCCTGCCCGACCGGGACCTGGCA CTCGCCGATGAGGCCAGCAGGTCTGACCCCCCACCCCCAGGGAGCCCATGGTGGGGCGGG GCGGGACGACAGCAGAAACACAGCCAGCTCCAGCATGGGACAGTGGCTGAGGCTCACAGG CAGTGAGGGGAGGCTTCCTGGAGCAGGTGGGCCAGGCCAGGGGCTGCACACACGCACTCA CACACACTCGTCACCTCATGGCTCTGGGTGGGTGCTACACAAGGAAACCAAGGCTTCCGC CAGGTGTCTCCTCTATCCAGTGCTGCCCAGCCGGGAGGTGACCGAGCCAGGGTCCCACCC TAGGTGTCCAAGCTCTTACCACACTGTGATACTCCCCGGAAGTGTCTAAGGGCCCGCCCA GATCAATGACCCCGCCAACGGACCGCAGAGGAGGGCAGGGCGGGATCCCAAAGGCTGACT CGGGAGTGGGGCTGGCCTTGACCGCCCCGGTGAGCACAGATGGCCTAGGTGTGAACCGGC CCCCAGGGCTGGCTCGGGATGTTGGCAGGAGCAGGGCATCAGGCTCAGCCCACGCTCCCC GGCCCCAGGAACGCCGACCTGTCCATCACGCTGGGTACATCGCTGCAGATCCGGCCCAGC GGGAACCTGCCGCTGGCTACCAAGCGCCGGGGAGGCCGCCTGGTCATCGTCAACCTGCAG CCCACCAAGCACGTAGGTGTCTGAGCCTACCCCTGCCCAGGGCCACCATGCACCCTCTGT CCCCCACGCCTGACCCGTCCCGCCCCTCGGCAGGACCGCCATGCTGACCTCCGCATCCAT GGCTACGTTGACGAGGTCATGACCCGGCTCATGAAGCACCTGGGGCTGGAGATCCCCGCC TGGGACGGCCCCCGTGTGCTGGAGAGGGCGCTGCCACCCCTGCCCCGCCCGCCCACCCCC AAGCTGGAGCCCAAGGAGGAATCTCCCACCCGGATCAACGGCTCTATCCCCGCCGGCCCC AAGCAGGAGCCCTGCGCCCAGCACAACGGCTCAGAGCCCGCCAGCCCCAAACGGGAGCGG CCCACCAGCCCTGCCCCCCACAGACCCCCCAAAAGGGTGAAGGCCAAGGCGGTCCCCAGC TGACCAGGGTGCTTGGGGAGGGTGGGGCTTTTTGTAGAAACTGTGGATTCTTTTTCTCTC GTGGTCTCACTTTGTTACTTGTTTCTGTCCCCGGGAGCCTCAGGGCTCTGAGAGCTGTGC TCCAGGCCAGGGGTTACACCTGCCCTCCGTGGTCCCTCCCTGGGCTCCAGGGGCCTCTGG TGCGGTTCCGGGAAGAAGCCACACCCCAGAGGTGACAGGTGAGCCCCTGCCACACCCCAG CCTCTGACTTGCTGTGTTGTCCAGAGGTGAGGCTGGGCCCTCCCTGGTCTCCAGCTTAAA CAGGAGTGAACTCCCTCTGTCCCCAGGGCCTCCCTTCTGGGCCCCCTACAGCCCACCCTA CCCCTCCTCCATGGGCCCTGCAGGAGGGGAGACCCACCTTGAAGTGGGGGATCAGTAGAG GCTTGCACTGCCTTTGGGGCTGGAGGGAGACGTGGGTCCACCAGGCTTCTGGAAAAGTCC TCAATGCAATAAAAACAATTTCTTTCTTGCA OMIM ID 606211