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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SIRT6 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006342 chromatin silencing IEA GO:0006355 regulation of transcription, DNA-dependent IEA GO:0006471 protein ADP-ribosylation IEA GO:0006471 protein ADP-ribosylation ISS GO:0006471 protein ADP-ribosylation TAS GO:0006476 protein deacetylation IEA cellular_component GO:0005634 nucleus IEA GO:0005634 nucleus ISS GO:0005654 nucleoplasm IDA GO:0005724 nuclear telomeric heterochromatin IDA GO:0005730 nucleolus IDA molecular_function GO:0003950 NAD+ ADP-ribosyltransferase activity TAS GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity ISS GO:0005515 protein binding IPI GO:0008270 zinc ion binding IEA GO:0008270 zinc ion binding ISS GO:0016740 transferase activity IEA GO:0016787 hydrolase activity IEA GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA GO:0017136 NAD-dependent histone deacetylase activity ISS GO:0046872 metal ion binding IEA GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) IDA GO:0070403 NAD+ binding IEA GO:0070403 NAD+ binding ISS

Protein-protein interaction details for SIRT6 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID ELF5 Two-hybrid physical 16189514 VIM Two-hybrid physical 16169070 CHD3 Two-hybrid physical 16169070 PRKDC Affinity Capture-MS physical 20157594 XRCC5 Affinity Capture-MS physical 20157594 XRCC6 Affinity Capture-MS physical 20157594 PRKDC Affinity Capture-Western physical 20157594 XRCC5 Affinity Capture-Western physical 20157594 XRCC6 Affinity Capture-Western physical 20157594 PRKDC Co-localization physical 20157594 RELA Affinity Capture-Western physical 19135889 RELA Reconstituted Complex physical 19135889 RELA Reconstituted Complex physical 19135889 CCNDBP1 Affinity Capture-Western physical 17131381 CCNDBP1 Reconstituted Complex physical 17131381 NR0B2 Affinity Capture-Western physical 20375098 VIM Two-hybrid physical 21900206 UBE2D1 Two-hybrid physical 21900206 CHD3 Two-hybrid physical 21900206 FAF1 Two-hybrid physical 21900206