Home

Search

Browse

Statistics

User guide

FAQs

Links

Questions

Contribute

Download

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PDGFB (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 5155 Official gene symbol PDGFB Full name platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) Aliases ,FLJ12858,PDGF2,SIS,SSV,c-sis, Gene summary The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq] Location Chromosome: 22   Locus: 22q12.3-q13.1|22q13. Gene position 39640957 - 39619685  Map Viewer Gene orientation minus Gene size 21273 bp Gene sequence >PDGFB:complement(19010254..19031526):Length=21273 CCTGCCTGCCTCCCTGCGCACCCGCAGCCTCCCCCGCTGCCTCCCTAGGGCTCCCCTCCG GCCGCCAGCGCCCATTTTTCATTCCCTAGATAGAGATACTTTGCGCGCACACACATACAT ACGCGCGCAAAAAGGAAAAAAAAAAAAAAAAGCCCACCCTCCAGCCTCGCTGCAAAGAGA AAACCGGAGCAGCCGCAGCTCGCAGCTCGCAGCTCGCAGCCCGCAGCCCGCAGAGGACGC CCAGAGCGGCGAGCGGGCGGGCAGACGGACCGACGGACTCGCGCCGCGTCCACCTGTCGG CCGGGCCCAGCCGAGCGCGCAGCGGGCACGCCGCGCGCGCGGAGCAGCCGTGCCCGCCGC CCGGGCCCCGCGCCAGGGCGCACACGCTCCCGCCCCCCTACCCGGCCCGGGCGGGAGTTT GCACCTCTCCCTGCCCGGGTGCTCGAGCTGCCGTTGCAAAGCCAACTTTGGAAAAAGTTT TTTGGGGGAGACTTGGGCCTTGAGGTGCCCAGCTCCGCGCTTTCCGATTTTGGGGGCCTT TCCAGAAAATGTTGCAAAAAAGCTAAGCCGGCGGGCAGAGGAAAACGCCTGTAGCCGGCG AGTGAAGACGAACCATCGACTGCCGTGTTCCTTTTCCTCTTGGAGGTTGGAGTCCCCTGG GCGCCCCCACACGGCTAGACGCCTCGGCTGGTTCGCGACGCAGCCCCCCGGCCGTGGATG CTCACTCGGGCTCGGGATCCGCCCAGGTAGCGGCCTCGGACCCAGGTCCTGCGCCCAGGT CCTCCCCTGCCCCCCAGCGACGGAGCCGGGGCCGGGGGCGGCGGCGCCCGGGGGCCATGC GGGTGAGCCGCGGCTGCAGAGGCCTGAGCGCCTGATCGCCGCGGACCCGAGCCGAGCCCA CCCCCCTCCCCAGCCCCCCACCCTGGCCGCGGGGGCGGCGCGCTCGATCTACGCGTCCGG GGCCCCGCGGGGCCGGGCCCGGAGTCGGCATGAATCGCTGCTGGGCGCTCTTCCTGTCTC TCTGCTGCTACCTGCGTCTGGTCAGCGCCGAGGTGAGTTGCCACGGCGGCTGGGGCTGGT TCTTCATTCATTACCTTCGCCCCCCCCTTCTGACCGCCCCCTCCTCTCCCTGCAGTGAAC TTTGGACCCTTGCAGCCCGCGAGCCTGACGCCGGGCGCTGGGTGACCTCTTCGGGCTGGG AGCGAGGTCCGGGGGTGACAGGCTCTAAGGGAAGGCAACAGCGGTGGCTTTCTTTCCAAC CGGCGGGCGAATCTGGCTCCCTAAGCCGTTCCGTGTCGGGGGAGGGTGTGTGTGGCCCTG TCCCCCACCCTTTGGGAACCCGAGAACAAGCCCCTTCCCGGCCGGGGGAGAGGGGGTGGG GTGGTGCCCAGGGTGCAGAAGGCAGCGCGTCCTCCCGAGCCCACTTCGGCGCCAGCCTCG GCTTAGGCTCTGTCCTGCCATCGGCTTGCCCAGGAGGTGCAAGCTTGCGCACCGGTGCCA TCCACGCCGACCTTTGACGGGGCTCGGGTCCCACCCTGGCTCCCGGTCGGGGTCCGGGTG GACGCCCTCCGGCACGCGCAGGGCATGCCCGGCCCCAGAGCACGGTCTGGAAGCAGCTTG TGTCTCGGGCGCGGGGTTTGGGGTGGGAGTAACAGGGAGAGAGAGAGAGAGAGAGAGAAA GAGAGAGAGAGAGAGAGAGACGGAGAGAGAGACGGAGAGAGAGAGGGAGAGAAAGATAGA GACGCAGGTAGGTTTCGGGCACTCGGGTAGGGGGAGGACTAGGGGCTCTGAAGGAATCCA GCCCCCGGGGCGCTGTGTGCCTGAGGCCTTGCCGTACCTGTGCCCGCGCCCTGCAGGAGG AAGCACCTCTCTCCCCCGCATGCAGGGTGCGGAGCGCGCCGCCTGCAAAAGCCTAGCTGC ACGGGAGATGGGGTATAAAAACATCTGAGGGAGCGCTGGGGTCGGAGCCGTCCCCACCCC TCCCAGCCTCACGTAGCCGTGAGTTGGCAAGTCTACCCGGAATCCAGGTGGGAAAGGGGG CGGGGCAGGACGACGCGCGCGGTGGAGGGGAGGAGAGGGCAGCCGGGAGCGCGGCGTGAC TGGGTACCGTCCCACCTCCGCCCGGCTGCGGCCGGGAGTCCGCACCTCGCCCGCACCTCG CCGGCTCCCGGGGAGGGTCGGCCCCTGCGGCCTCCAGCCAGGCGCAGGAAGGAGGCAGCG GCGGCGAAGGGGTTAAGGCGGAGGGCTCGGAGGCCGCGGCCCGGCCTTGGGCTGCCGCCA GCGCAGGTTGTTTTGACCACGGAGGAGCCGTCGCCGTCTCCTTTTGTTCTCGGGGCTCCT CGAGGGCCGCAGGCCGCCCGCCCGGGGGCCCCGCCCTTCCGCGGCCGCCCCCCGCGGCCC GCACCCGGGAGGGAGGACGCGGGGCTCGGCCGGGCCGCCTTCAGGCCCCTCCCGACGCCC CCTCTCCGCCTCTCCCGCAGCCCCCCGGGCCGCGGCCAGCTGTTGGGGAGGGGGTGGCCG GCCGGCCCCAGCTGCCGCCTCGCCTCGCCGTGGGACCTGGGGGCTGGGCCCGGTGCCAGG GCGTCCTGGGAACGGCGGCGCCCCGTGGCTGCTCTCCGCAGCCCACCCCGCCCGGGCCCC CGACTCGCTCACTCACCCCACGCATGCACACTCCTGGCCGGAGGCGATGCTGCGCTCCGG CGGGCGGGCGCGCAGAGCGACGGGCACGCACTACCGCGGCCAGGTCGCGCGCCCGCCTCT GCCACGCCCGTGCACACGCGGGACACACGCGCGCGCACCGCACACAAACGCACGCACGGC CCCTGCACGCGCGGCCTGAGCACACGTGCGCGCACACCCACGCACGTACACAGGCACGCA CGGGCCCCCGTGCACCCAGCGCCTGGTGCTCGCCCCCGCGCAACAGGTGGGCCCTCCGTG GGCCCTGGCACCTCACCACCTCTGTAGCGGCCCCATTTCCTTCCTGGCGTCCTGTGAGGG AGGGAGAACCTCCCATCAGCACCACAGCACCTACTTTTTTTTTTGCCTCGTCAGCCCGAC GCCCCTCAAACCTTACCCATCTGTGACTCCTTTTTTTCAACCACCTCCGCGTGGTGGAAA ATGGTGGTGATGTGACTCTGAGGGGCACTGAGCTGTCCAGAGCGATTCCCCCTTCACATA AGCCTTCATTTGAACCTGCAAGACTGGAGGGACCTGGCGTGTGCAACCGCGGAGGGGGCT CCCACCCCTGGCTGTTGCATTCTCTTGGCTGATCCCAGCGTGCCCCGGGGAGGCCGCTGA CAGCTGGATGTTTCCCCAGCCTCCCCTTACCATTTCCAGCTTCGTCCAGCACCTCCTCCT TCTTTCCCACAGCTCCACGGGCTCGTGTATCTGGGGTGGAGGCTGTGGCACAGAAACTGC CTTTCTCCTCACTTTAGTCACAGCATTCTTGAACACATGGCCACAGGCGCGATGTATGTG GCACTTTGCAGTTTATGAAGCACTTTGCTGCTAAGCCTGAGTGAGCCTCAGGCTGGCCCT GGGGGAGGGGACCTGCATGGGGATGGAACCACGCAGGGGTCAGTCCAGGAAGGAGCTGTA ATGGCCAGTGCTGGGAGAGTCAGGGCAGGCCTGCTGGTGGAGGTGGCCTTGGAGCTGTCC ACGTCCTGGTCGTGCTCGGACTAATCTTTCAGCAGACGGCAGGCAGCCGTGAGGCAGGGC TGGGTGGAGGGCCTGCCGAGGCCTCTGAGGTGCCATCTCCACCAGCTGAGCTGGCTTCCA GGAGGGCGAGTCCCACTGTCACGTGACGCGTCTGGCCTCAGCACACTTCTTCCGGGAAAG AGTGAAGGGCCCCACTGCCCTTTGCCATCCAGCTTCCTCTGGCTTTGCTAATGGCCCTAG GGGGCAGGAGACCAACTGCTGGAATCCCAGAGCCCTGGAGGTGTGCAAGGGCAGGTCAAA CAGAATTTGGAGGATCTGGTGCAAGAGCCAGGAAGAGAGAGAGAGAGAGAGTGTGTGTGT GTGTGTGTGTGCGCATCTGAGAGAGAGAGAGAGAGAGACTGACTGAGCAGGAATGGTGAG ATGTTTATCATGGGCCTCGTAAGTACCTCTCCACGTCTTGTCTTCCCCTCCCCACATTGA GGAGCCTCTTCTGTGACAACTCTTCCTATGTTCTGGTTTATTTCATTGTTTATTACCTGC TTTCTCTACTGGAGTGTCAACCCCATTAGAGAGCTTTCCTCCTGGTCCCCACTTTTAGAA CAGTGCCCAGAGCCCTGTGGACAATCAGTAACTATTAGTGCAAAGAACAGTTAGTGCTGG GTTGGTGGGGAGGGCAGGACCTGGCCCCCTGTTGCTCCATGGCCCCACTGAGTCCTCGCT TTGCTCTGCTCCGAGGGCAGCCCCCCTTTTCAGCCCTCTGGTAGGCATCAGTCTTTCAAA GCCCCCCATCTTGAGAGAGAAGCATGTCTGTCTCTCCTCTGTCTTGGGACTTGGGCTACC AGGATTAGACAGGACAGAGGAGAAGAAACAGAAAGAAAATCAGACTGCAAAGGTTCTGTG TATCTTTAGCTGGGGCTAAGTTTCTGCCACCTAAAAAAAAAAAGAGAGAGAGAAGATTGG ATTAGTGCAGAGTTCCCAAAGAATGGCAGAATCCCCTGGCCCCGTCCCCTGGCTGGGATG GGGATGGGCAGTGATTGCCGTGGTTGCCAGTATTATAAATGGCTGGACTGGTTCCTCTCT TCCTGCTTTAATTTTCCTCTGCTCCTGCAAGAGGTGGGGAGGCCAGGGTTCTGGGCCCAC GTGAAGGAGCAGAGGCTGAGCGGGAGGGTCCCAAGAGCAATAAAGAAGGGGAATGCTAGG TGGGAAACACTGGTTCTAATGGCTTCTGTGGTTTGCCCCGAGAGGGCTTCTTCAAAGGGG TTGGTTGGCTTTGGCATTCGATCTAAATAAGGCCTGCGACTCTCAGGCAGGCAGGCTCTG GGAGGCCTCATCAGCTTCTTCCTCTGCCAGCCACAGACAACGCCCCTGGTTGCTTGGGCC TGTGTGTCCCTTGGTGGGAATGGCAGGCGGGCCGGGGAGTGTGTATCTGTGTGTGTGTGC TGGGCCCAGGAGGAGGGTGGGGTTCAAGCCCCTTTGATCTGCCAGCCTGGTTGGGAGCAG ATCACTCACCTGGCCTCACGCTCGCTCGTGCCCTTCCTACCTGCTGCAGCTGGCGCTGGG GGCGGGGTCGGAGGAGGCTGTTTACCTTGGCTCCCACGGCTGGCTTTGCCCCAGCTGCCT CCTCGCCACGCCCTCACTCTGCCAGAAACCCCGGGCCTGAGATCTTGGGACAGCTTCTTC AGGGTGCCAGGCCTCCTTTCCCATCTCTGAAGTGAGCTGTCCACCTGGAGGCCTGCGGAA CCTGTGCCCAGGAAAACCAGGCTCCGGGCGGCTCACCTTCCCATACCAAGAAGAGCCTGT GACTCCCAACAGGTGCTCATGCTCGTCATCCCCAGAGCATTGCATCCTGGAGCTGAGCAC GTGCTGAGTGTCCCCCCACCCTCACCCACCCCCAGCCCCGGAAGGGCCTTGTAAGCCCAC ACGGCCCAGGCTCTGCCAGTGTGGAGGTAGGGTACCATTTCCTGTGGCCCAGCACAAGGG ATAATGCAAAGTCACGCACTCTTTCATGGGCAGGCAGCTCTCCACCCACTCCTTGTCATC CTCAAAAATGTCCTGTGCTGCTGGCCCTGAGCACGTGTGCCACTCGCTGCTGCCCACAAA GGAGCCATCCGGAAAGAATTAATGATGATGACAGTGACAACTCATTAAGCTCCCATTATC TGCTGGCAGCTCTGCTCTGTGCAATTATGCCTCCCAGTAACCCCGGGCGAGGTATTATTA GCCCCATTTAAAAGATGCAGAAGCCGAGGTTTTAGATTGTGACAAGATTCCAAGAATCCA GGTTGCCCTGGCATCTGGAGCCCTTGCTCTTTCCTCCGCTACAGGGTTTCTCAGCCTCTG CACTCCTGATGTTTGGGAAGGCCGTCCTGTGCCCTGAAGGGTGGTGAGCGGCATCCCCGG CCTCCCCCAACTTAAGATGCAGTGCACACCCCAAGTTGTGGCCACCAGCGATGCCTTCAT ACATTGCCACTGTCCCCTGGGGGCCCACTGGGCCCTGGTTGAGAGCCTCTGACGTGGGAC ATGCTGCAGAGTAAAGAGCCAACACGAACCTTGTGTGATGCTGAGGGCCAGTGGCCTTAG AACACAGGAGAGGGAGGCTGAGACGCCCCATGGTGGGCTGGAACAGGTGGGCAGTCTGGA GCCTGGGAACGACCCAGCTCTGCCACTTGCTAATTGTCTGGACCTGTTGCTGCTTGTTTA ATTTTTTCTAAGCTTCAGTGTTCTCATCTGGAGGATGGGGATACAAATACTGCCAGCCTC TTAGGATTGGTAGTTTATACGGTGTTTTTCTCAGCGTGTGGCTTGTAGCTGGCATTCATA GATGTTAGTTGTGGTATTATTACCAAATCCGGGGGCTTATGGGTAGTTCTGGGCATCTAG TGGCCACATTACCAAAAGCATCTTCAGGGACGGTCTCCCTGCTCAGATTAAAAGGGACTC TAGTTGCTCATTTGCCTAGGGTTGGGGAAGAATATCCCAGGTGGCCCTCCTGGTGGAGGA GGCAGAAGAATCATACTGGACAGAACCTGGAAAATGGTAGACTCCTTCATGCATTTGACC AGTATTTACCGAGGACCTACTATGTGCCTCTCTCTCCTCCTCAGACCCTATCCTGGGCTC TTTCACACTCAGCCTTGGAGGGGCATCTCCTATGTGTCGTGGGCCTGGATCTGGGGTGTC CACTCGGCCTGTTCAGGGGTCTGCCTCCTCTGCCGTGGCTGGCAGCTGCAGCCGGCTCTC CAGTGGGCAGGGAGATCTTGGCACAAGCACTAAATGCCATTTGCTACTAGGCCTTTGGGC CCCTCCCCTGGGGGGTTAATTGAATCTTTACTCCACAAACGCTTCTTGTTCTCCTTCTGC CAGTGATCCAGGGAGGCCTGGCTAGGCACCCGGCTTTGGCGTTTTCTCTGCCCCTTCTAA CGCCTCCTGGCAGAATTAGAATTGAATCGAATGTTCTTCAAGCCCCTCGATTCACAGATG AGAGCCAGGACCATAGGGGCAGTGACCAGCCGAGGTCACACGGCAGTTGGTCCAAAGGCG TGGGATTCAGCTCTCTGGCCTGCCAGTTCTGGGTTTGACAGAACTCTCAGGGGAAGCGGC TTTCGCTGGTGTTCACTGGAGACCAAGCCCTCTGTTCTGTGGGTTGGGTACTTTGTCAAC ATTTGGAGAGCACCGGAGGCGTGGTCTCTCTTCTGAGGTGGAAAGAATGAACTTGCTTGA GGGCGGGAGGAGGCAGAGCCCGGAGGAGATGGGGCCGAAAGTGAGGGGCAGCGGGGCCCA TACCCTCCTCTGTCTTGCACGTGCAGCCCCTGGCTGCCCGGATATTGAAGGAAAGACCCT AGTTCTCAGCCAAGCCCTGCCACCTTTTTTTCCTCAAGTTGCCCAGCAGCCCTTAGACAT TGGGCGGAGTTGTAAGCTCCATGTTCAAACAAAGACATGGAGACTCAGGGGTTTCAGGGA ATGATGTAGCTTTAAAAGTGGTCACCCCCACCCCCCGCCCTGAGTCTTCTGGCTCCTGGA TCGATGTGGGTGGCCAGAGTTGGTCATGGATGAACCCCTGGAGGTGTTGCTAGACCTCAT GATAAGCTGGAGGAAACAGAGCTTTCGGGGAGAGCCCCCTGAGGCTGGCCACAGGGCTGA GACGACCTCTTCTCCTCTCCCTCGCTCCCCCTCCGCCGTCAGGCAGCGAGAAAGCAGCAT CCCTTTTGTGAAGGTAGCCTGCACCGACCCCCTCTGAGCCCCCCGACCTTCGGCTCCGGG AATGTGGAGCGAACCAAGAAGGGAAGTCCTCCCTTCTTAATCCAGGGAAACTGAGGCAGA AAATAGTTTAACCCAAGGTTCTATAGTAATGTGCCAAGCCTATTGATGCCCTCTCCAGGA CTGTCTGTCCAGACCGTGCAGCCCGAGTGCCTGTGCCTGCACGTGTGTGTTTGCACACGT GGAAGTCCGGTTCCAGCCTTTGAACGTGCAGCGACATCTTAGGAATTTTCTTTGCTTCTC AGTGGCTGGTGGTCTGGATTGTGATTCTCAGTCTCCCATCTGCCCTCGCCTCTTTCTTGG GATCTCTGGCATCCGCCCCTTGGGTCTCCTGGGACTGTGGGGGACGTGGCTGTGACCTTC CTACGGGGCTGCTCTTGTGTCATTGTGGGACCTGCGGTTTCCCTGGAGGAAGCCCAGCTC CGAATGAGGCCTGTTGAAGTGTTATCAGGTTTCGAGTATGTTTGGCAACAGGCCAAAGGG GCTCTAAAAATAGGGTTTGGTTGGGCACAGGGCACGGGTAAGCTTTCAGGTTTCCCGGCC GTGTCCGAGGATTCCCTTTTCGCCTCTTTCGAGTGAGAGACTTCATAGATACCGCTAGGA CCTGGGGCCTCCTGAGGCCATCGCACTCTGCACGCGTTTATTAAGCACCTCTTGTACCCA GGAGCCTGGGAGTACAGGCTCTGTCATCCCAAAGGCATGGGTTTGAATGCAGCTTTTGCC AATAATTGAGCCTCTCTTTGAACGTTTGTTTTCCCCTCTGTAAAATGGGGGTTAGATTGG CCATGGGAGATGCTGGCTGTCTTCAGCTGTCAGGTGTGTTGTGAGACTCAGGGAGAAATC AGATTTTGGTGCATTCCCAGAACATGTAGTTTGGTGGGGGAGACAGACATAGAGACAAGC AGGTCCAACTCAAAGCAAGCTGGGGTTCCTGTTGGGGGTTGAGGGTGCAGGGACTGAGCT GGGTCTCAGAGGCTTCGGCAGGTCCAGGCCCCGAGGCCTTTGTGCTCCTGATCATCAGGC CTGGATCCTGCCTGTCCGTCTCCCTGTGACCTTGGAGCTTTCCACAGGAGAAAGCGAGAA AGCGTGTGGTGGGGGAGACAGCCATGCTGGAAAGCCCCCACTCCCAGCTCACTCAGCCTT TTGGTGTCTGCCCGGCAGGGGGACCCCATTCCCGAGGAGCTTTATGAGATGCTGAGTGAC CACTCGATCCGCTCCTTTGATGATCTCCAACGCCTGCTGCACGGAGACCCCGGAGGTAAA TGGAATCCTCGCCCCGCGCTCCGGCCCTCCGAGGAGACTTTAAGAGATCTGGGAGGGGCA GGACAGGAGGCATCCCTCCTTCTTGACGTCTGGAGAACTAGAGGCCCATGGCAGCCCAGA GAGAGCGTGGCCACACCCATCCAGGGCAGGGCCGAGTCAGCAGGCGGGTTGGTACCTGGG ACTTGGGGTGTGGCAGGAGAAGCACCCACGTGTGGCTCCGGCTTGGTGCCAAGGGTGGGG TGCCAGGAGGAGGGAGGGCGGGGAGAAGGTGCCCAGGGCATCTGCCGAGTATGTCTCCAG GTGTGGGCCCAGCCAGGGAGGGTGGCACTGGAGGAGTCATCTCCCCGCCCCTCTGGCTAG GGGCCCGGTCTGTGAGGTCCCCTGGGGACACCTGGCCTCGACCAGCAGGCAGCCCTGCCC GTGCCCCAGAGCTCACTCAGCGAATGGGCACGTGCTCGGTGGCACACACGTGGCGGGGCT GGCGGGCTGGATTGACAATGTATTTATAAACGCTGTCTTCAGAGCAAATTCCATTCTATT CTAACCTCTGGCCTGTTCCCTGGAGCCCTGGTCAGCAGCCCCCCTGCACCCCCAGGTCCC CTTCCCTCTGGGGTTCTGTCTCTTTGTCACTTTGTAATCCTTGCCCAGACGCTATCTACG GGGGAACAGCATTTCCTGCCTTTGTTTCCTCTCCCCGTTGGGCCCCTGGCTCCCTCTCAA AAGCATTCCCGGGCCCTTTCAATCCCGCCTGTGCTGGGGGGCGGTGAGGCAGGCAGGAGG GGGCCCCAGCTGGGCCCACCTATTGTTCGCCAGGGCCCCCACCCGATGTCTCCCACAACC CCCACCCTATGCCCGACTGGCCGCCCCTGGCCACACACAATGGGGCAACTTCCAAATTTA GCCTTTCTACCATTTCTTTCCAAGCCTTTACACCCCCACCCTCAGACGGCCCCTCCACAC CCCTGGTGGGGGTCGGGATCTTGGAGATGAGGTTTCAATAGCAGGCCTGTTTCAAGGCAA CCATGTGGCTATTTTTTCCTAATCAACTTAACCTTTCCACAAAGCGCATCTTTTCCCCAT CTCCTCCCCACCAGGGACATTCCAGAGATGGCAGGGAGAAAGGAAAGGAGCCAGAGGGAC AGATAGGCTCGTTGACGTAGGGGCTGTCAGGCTGGACGGAAGCGGACTAGTCATCAGACT CCCTGCAGTACCCGGGACGGACAGGCGGCAGGCGCCTTTGTCTTGGATGGGGCCAGTGGG TCGGTGCCAGAACTGGAGCCATGGGGTGCTGTGTGGAGGTGGCAGGAGCGTGTTCCCAAT GCCCCTTAGTTTATTTGTGGCTCCTCACCCATGAGAGAGACAGAAGGGTCTGTCCACGCC TTAACATCCAGCTCAGAGGCCTCCCTCAGCCCTCACTTCCCAGCAGCCAACCTCTGGCCA TGGGCTCTGGAAAGGACCGATGTCTCCAAGGAGGGCTGATGGGACTGAGATGGTGCCCAG GCTAGAAAAGGGAGCTGTCATTTGTGACCAGAGGAATCAACAGACGGCTGGGGGCAGAGG TGGGGCAACAGTTTAGAGAAGGGGAGGGAGACAGACACAGATACAGATACGGTGTGAGGG CCCCGGAGCTAGAGAGACCAGGCCCTAGAAGGGTGTGTGGCAGGGACTCCCCACCCCCAG CAGGCCCAACTCCCACCCCTCTTCTCCTCTTCTCTGTCTTCAGCTCCCACCCCCATCCCT CTCCCTCCCTCCCTCCCTCCGTGGCTCCCGCCTGCCCAGCGCGGCCATTGTCCGGGGCTC CAGAGGGGCTGTGTTCAGGGCATGCGGTCCCCCTGGGGCTTCTGGGAATTTCTCCATTCA GCACTTCCTATGGGAACGCTGGGTGGAGGGGCACTGGAAACTGGCCTTCAGTGCCCTAGG TCCCGGCCCCGCCCTGGAGGCCGAGGAGGGTTCACTTACAGTAGCAAAGGGGAAGGGTTA TTTTTAACTCCACTGACATGGGTTCTGGCCAAAAATGTTGGCTAAAGAGCCAGGGATGCA GTCAGGATCCTGGGCCTGCAGCTGTCCTGGGGGCTGCTTGGAGGGTCCCTGCTCAGGGCC AGGACCCGTGCATTTATGGGGGCTGGAAGGAGGGACTGTTCTCTGGAGTGGGGGAGAGGC AAACCTCCCGCCTGCCCAGACACCCCGGCGGAGGGAGCCCCTGCCCAAGGTGGGGCCGCC TGGTGTCTGACTGTGACTTCTCCTGCAGAGGAAGATGGGGCCGAGTTGGACCTGAACATG ACCCGCTCCCACTCTGGAGGCGAGCTGGAGAGCTTGGCTCGTGGAAGAAGGAGCCTGGGT AAGACTGAGACACCCAACAAGGGTCCTTCAAATTAGCATGGGGGCCAGGGAAAGAGAACG GGGGCGGGCAGCCAGTCGGAGGGCCCCGAGGGTCCTCTTACAACTCCCGTTCCCCCCACA TTCAGGACTGAGCGAACTGAGAGAGTAAAACCATCCTTAAATGCCTGTGTTCAGTCATCA CAGCCCCTCGCCCCCACACTCTCTGGTTTCTAAATATAGTGCTGCAAAGCTCATTCGTTC CTTATTTCAATCCTGGAGGTAGATATTATTAACCCCATTTCACAGAGTTGGAAACTGGGG CCCAGAGAGGGTAAAGAACTAGGCGAGGTCACACTGCTAGGGAGCGGTAGGGCTGAGATC CCAACCTGCTCCCCTCACTTGAACCCAGCGTGGTCCCTGATGGGCTATGGGTATCTCCTG TGGCAAAGGGCCGCGGCCTAGGCTGGTAGACCTCGAGCAAAGCCTGGAACTTCCTCCTGC TCCCTTGCAGAGACCTAAAGGAGACCGTAGATCATTAGGTCCCAGAGAAACCCTCCCAGG TGAGGCAAATGTCCACTCAAACCCCTCCTCCTCTTTGACACCTGGAGTCCCCAAAACACT GCAGTTAGAGGCTGGGGGAACGATGAATAAGAGTCAGGTGGCCTGGGCCGGGCATGGTGG CTCACGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGCAGGCAGATCACGAGGTCAAGAG ATGGAGATCATCCTGACCGACATGGTGAAACCCTGTCTCTATTAAAAATACAAAAATTAG CTGGGCGTGGTGGCAGGTTCCTGTAGTCCATGCTACTTGGGAGGCTGAGGCAGGAGAATT GCTTGAACCAGGGAGGCGGAGGTTGCAGTTAGCCGAGACCACGCCACTGCACTCCAGCCT GGCGACAGAGCAAGACTCCGTCTCAAAAAAAAAGAAAAAAGTCAGGTGGCCTGAGTTCCA CCCCCAATCTATGAATGTGGGCGGACGGGATATTCAGCTCTCAGAGCCTCCTGTCCTCTG TACATGGATAGCATCGGTAACCTCAGTGCTTGCTGTAGGCAAGGCTTACTCACTTTACAC CTTAGATCCACATGGGAGGGAGGTGCTGTTATTATCCCATTTCATAGAGGAGGAAGCTGA GGCTTTGAAAGCAGCAGTGATGCAGGAATCCAAGGCACCGTGAGACAGCAGTGCACGCGT GGTTTCGAGCTAATATGGTACCTGCATAAAAACCACATGTTGGGCAAGCCCATAAATGTG TAAAATCATAAAGAAGAATAAAATAGTCATGTGCCAGCAGAGGGAAGCGGACATTTACTA AGCATTTACAACATGCCCCACACTCTGAATTTTCTCACTTGAAACTACAGTGGTTCTTGG GTGTAGATCTCATGGTCCCATTTTCAGATGGGGAAACACAGGCTTAGAGTGGCTCAGCCA TCTGCCCAAGTCCCATGGCTAATGACAGCCAGGACTTGAAACCTGAACCCTGGGGTTGAA GGGCGTGAGAAAGAGCAGTCCCGGAGGCACCCGCTGAGCTCCCCTGCCAAGTGGGGGGAC TCTGGACAGGCCTACGCTCCTGACCCAGGTTTCGTCTCCTCCCAGGTTCCCTGACCATTG CTGAGCCGGCCATGATCGCCGAGTGCAAGACGCGCACCGAGGTGTTCGAGATCTCCCGGC GCCTCATAGACCGCACCAACGCCAACTTCCTGGTGTGGCCGCCCTGTGTGGAGGTGCAGC GCTGCTCCGGCTGCTGCAACAACCGCAACGTGCAGTGCCGCCCCACCCAGGTGCAGCTGC GACCTGTCCAGGTGCGTAGGCTCCGCGGCCCCCCGAGGCTGGTCCCGGTGGTGGGTGGAG ACCACCCTTCTGGGGCTCATACCTGACCAGGCTTCCTTGACTGGGCAGAGTGGTGTGTCG AAGGACATTCCTGATTTGTTCCTGGGCTCTGTCCAGAGAGGCCCACTCTTGGGAAGCTCT TCCTAGGCAGGTGGACTGAGGCCGACCATGAGTCCTCTGAGGTGGCTCAGGCCACTGTAG CCAAAAGCCACAGACAGACCCCCCGGGCTGGGCGAGGTGTGGAGCCAACGTGAAGTAGGG ATGTCACCTCCTTTACAAGGACAAAATCGCAAAACGTCCCTTGAAGAGCCGTATCCGCAA ACATTTATCTGACACTCAGAATGTTTTGGGGAGCTACTCAGGTTCCCCCAAAGCTCTCCC TATTCAGGGCTGTCTTGAGAAAGGCTCAGATGGGTGGCCCTGCATCTTTGACACCTGCTT GTCTCTCTTTGACAAGCTGTGTCTTTAATAAAGAGAGTGCAGAGAGGCCCACCAGGTGAT AGACACTGCGGAGCTGGGGCAGGTCCCCTGACAACAGTGGAATGCTGATCCTGCTTTTCT TCGGAGGGACGGGGGATACATACACTGGACTCAGGGAAAATTCTAGAGTAGAGGCTGTCT CAGGGAGCACCCTGGTCTCACCCTAGTCGGGGCAGAGTCAGAGAAGCTGCTGCTTCTGCT TCTTGTGGAAAGATTCCTGCACGCCCCAGGCCAGCCTCGCCCACAGGCTGGGCAGTGCGC ATTTCTCTAGCTCAGCACCGGCCCTTGCCCGATGCTCTGCCTGCTTAGCCGCACTTCCTT CTCCTGCCACCAGCCCGTGGCCTCTCCTCCTGCCCACCTTCCCTCCCTGGCTTGGGCCCC ACGCCTGAGACTACGAATGTCACTCCACCCCACTGCCCACTCTCGTGGTATCTCCTGTCC TCGATGCTTCCAGCTCTATGGATGGACACCTGACATCTGACCTCCCCGTTCCCACCTCCC TCCTAGATGAAGCCTCCCCCCACTTCCTTCCAGACAACCATCTCCCGCCTCTGCCGCAGC CCTGACCTTGGCTGGCGCTCCGGGAATGAGGATACCGCAGGCCCCAGCTCAACCCGGAAA TGCCTTTCTGGCTGTCCCTCTCTGGGGGCACTGAGGGGGGCCCCAGGTCGGGAGGGCTTG TTTTGATGGAAAAGCTACGAGAAGGGCAGAGGTCAAGGTCCTGCTATTGTTTGGGCCAAA GCTTTTGCCCCACAGCCTGCTCTCCGGGCTTTCGAGGAAAGATTGCTGCAGGGGACACCG GGGTGGGAAGCGCAAGCCATTCGGGCTTCCCGGGCTCCTGGCTGTGTGGTCTCTACAGAG GCATTTTGTGGCTCTGTCCTCCAGGTGAGAAAGATCGAGATTGTGCGGAAGAAGCCAATC TTTAAGAAGGCCACGGTGACGCTGGAAGACCACCTGGCATGCAAGTGTGAGACAGTGGCA GCTGCACGGCCTGTGACCCGAAGCCCGGGGGGTTCCCAGGAGCAGCGAGGTAACCACCTT TCCAGGCTCAGCCCTCAGCCCCCTTCCCCTGCAGCAGCTGGGGGCAGGGGCCGGTCTTAA AAATGGAAATGGGATCAGGCCCGCCCCCGGTTAAATTCACGGGAGGCTTTCTTTTCATCT TGCTGAGACACAAGCCAGGTTCCTCCCTGGCCTGAGAGCCCTACATGAGGATTAGCCCCT GGCTGGCTCTCTGGTCTCTGCCAACCAGTACCCTTCACCTGTGCCACCCCCGCCGGGCAG GCCTCTTTCAGTAACTAATGGAGTTTCTGCCTCAAGGCTTTAGCACACACTGCTGTGGCT GAAGAACACTTCTCCCAGCTCTCCACAAGCCTAGCTCCTTCTCTTCATTAGAGTCTCAGC TCAGAAGTCACCTCCTCCTAGAAGTCTGCCCTGACCACCCCATCCAGAGCAGCGCCATTT CCAGTCTTGCTACCATAGCCCCCTGCTTTGTTGGATGTGGGGATGGGATGGTGGAAGGAA TCTGGGCCTGGATGAGAGAAAGCTCCGCGCACATCAACTTCCGATAGTGAGCAGCTTGTC CTGGGGATGAGAAATCAAACGAATTTCTCGTATCCTTGAGCGGGGGAACCAGGACCAGTG GGGAGAAGCCACTGGAGAGAGATTTCAGCTCCATATGCAGAACAGCTAGCTGGTGATCAG TCAGGGGTGCAAGGTGGAATTGGCAGCATTGTGAGGCATCTCTACAAAAAATACAAAAAT TAGCCAGGCATAGCGGCACACGCCTGTAGTCTCAGCTACTTAGGAGGCTGAGGTGGGAGG ATCGCTTGAGGCTGGGATGTCGAGGCTACAGTGAGCCGTGATGGCACCACTGCACTCCAG CCTGGGCAACAGAGCAAGACCCTGCCTCAAAAAAAAAATGATTAATACGATTAGATGAGC GTTTAAAAAAATCACGTAAGTGATAGTTCTTTTTCAGTAACTTTCTATTGTTAGGGACAG GACAATCTTTTCATTCTCATTTCTTATTAACAAGACCCTGAAGACGGAGCCATTTCTTGG CATCTGTGTCTTATTCCCAGAGCTGAGCTGAGTCGCTGGATGCCATGGAAAGGCTGATCA TATGACAGCTTCAAACTGACATGTTGTAAATTATTGAGTTAATATGGAGGGTGATTTCTC TATTAAGGGAAAATTATATATATCTATATATATATATATTTTTTTTGAGGCAGTCTCACC CTGTCACGCAGTCTGGAGTACAGTGGCACAATCTTGGCTCACTGCAACCTCTACCTCCTG GGTTCAAGCAATTCTCCCGCCTTAGCCTCCCGAGTAGCTGGAATTACAGACACATGCCAC TACACCCGGCTAATTTTTGTATTTTTAGTAGAAACGGGGTTTCACCATGTTGGCCAGGCT GGTCTTGAACTCCTGACCTCAAGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATT ACAGGCGTGAGCCACCACGCCCAGCCTCTTTCTTTTTTAAGAGACAGGGTCTCTCTCCAT CACCCAGGCTGGAGTGCAATGGCATGATCATAGCTCACTGCAGCCTTGAACTCCTTCCTG GGCTCAAGCGAGCCTCCCTCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCATGTGCCAC CACGTCCAGCTAATATTTTAAGTTTTTGTAGAGATGAGGTCTTGATTCGTTGCTCAGGCT GGTCTCTAACTCCTGGGTTCAAGTGATCCTCCCACCTCAGCCTCCCAAGGTGCTGGGATT ACAGGCATTGAGCCACCACGCCTGGCCTTCTTTATGTTTAGAGTGAGTTACTTCATGTAT TTGTTTGACGTAATTTTCTAAACCAGTTTCTTGGGAGGCGCATTATACCAGTGAAACGTA GATGATGTAAAGTCCCATCATTTTAGTTCCGGTATTTTGGTTGAGTATGACGGTGTTTCT GTCACCTGTCCATGGGCCTGGCTAAGGCTTGGTAGTGTGGCTCTCTGTGATAATGTGGTC AGTGTCAGACCTCCTGGGCTCAGATCTGCGTGTTGTCACTTGAGCTGTGTGGTGACCTTG TGCTTGCCTGGGCTTGGTATAGCCCAGTGTCCTGCTGATGGCCCAGGCTCTGGGGAAGAA ACTCCCTGGGCCCTTCAGTGGCCCTCCTGGTGTCTTCTGTCTGAGGGGATCTGAAGCCCA TTCAAGTCCCTGAACTGCTAGAAAATCTGCGCAATTGCAGAGATGGGAGAGCTGCCTCGT GGGAGCTGGTGTCTGTAAGGTGGGAGGTCAGGTGTCAGATCCCGGTAGGCTGGGAGAGCT CAAAAGGCTCCCAGGAAATGGCTGGCCTTGAGCTCAGCAGACACAGCTGTCCCTGCCAGG GTGGCCACCTGGGAATCCAGGACGGAGAGAAGTGTATAAGAGCTCCCCTTGACTGAGGCT CACAGGCACTGTCGTTTGTGCTGAGTGGTTGGAGGTGTGCACTCTAGAGGCAGATCCCTG AGTTCAAATCCCAGTCTCTCTGCTTCAGTTTCCTCATCTGTAAAGTGTGGGTAACAGCAT CTGCCGGTAACAGCACCTGCCGTGAAGGGAAATGAGCATAGAACAGCACCAGGTACATGG TAAACACTAGCTGGGGGGTTTCTGGCCATTTCCATGTATTGTCTCCTAACGCTAGGAGGC CAGGGCTGCTGTCTTCTCTGCTTTAAAGATGTGGAAATCGGCTGGGCGTGGTGGCTCACG CCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGGATCACTTGAGGTCAGGAGTTCA AGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAACCAG GTGTCATGGCGTATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGGATCACTT GAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAAT ACAAAAATTAACCAGGTGTCATGGTGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGAG GCAGGAGAATCACTTGAACCTGCGAGGTGGAGGTTGCAGTGAGCTGAGATCGCGCCACTG CACTCCAACCTGGGCAACAGAGTGAGCCTCCATCTTAAAAACAAATAAATAAAGATGCGG AAATCGAGGCACAGGGCAGTTAAGTGACTTGCTCCAATGTCCACGATACGTGGGAGAGCC CAGATTTGAGCCCAGGTGGGTCAGATCCTCAGCCTGAGTTGTGGCCCATCCCACTCTACC ATTTCTCAGAGTGGCAAGGGGCAGGTAGGTGACAGGCACAACTGACCCGAAGGCCCAGCT TCATGGTGGGAGTATGATTCTGGCCCAGAGCCCAGTGGCCTCCACACCACGTGATCGGAC GGGGCTGAGAGGTTGGGAGGAAACCTCAATAGTAGGTCAAGCTAAGGAAAATAAGAAAAA AAAGTGAGTCGTAGCAGCTGCCATGTGCTGACCACTTCATACTTGGAGCTTTTTATTATC TTTCCCAGGTCTGGGGGTTGACTGGGCTCAGCTGGGCAGTTCTATTGGCCCCTCTATTGG TTGCAGTCAGCTGGTGGCCTGGGCTGTGGTCATCTGGAGACTCAACGGGGACAGCTGGGC CTCTTTTCCTCTCCCTGTAGTCCAGGGCCTCTGGCTCTACGGGGAGAGCCAGTCCCCACC AGGCCTCTCCATGTGGCCTCTCCAGCAAGGTAGCCAGACCTGTTATGTGGCAGCCCAGGG TCCCCCAAAGCATGAAGGTGAGAACTGCCAGCCCTTCTTAAGACCTCTGCCTGGAACTGG CACGGCACCACGTCTGCCTCTTGTTGGTTAACCAGATCCAACTCCAGGCCAGATTCAAGG GGCAGGGAAATAAACTCTATTGGTCAGTGGGCAATGACAAAGAACTTGAAGCCATATTTA ATCTACCCGGCTCTGTGTCCAGTACTGTGCAAAGAGCTTTGCCAGCATACTGTCATTTAT TCCTCCCACCAGTTCTATGAGGTGGGCAGTCTTATTACCCCCATTCCACAGATGGAGGCG CCAAGGCTCAGAGAGTTTCAGTCATTGTCCCCAAGGCACATACAGCTGGTGAGCAGTGGA GTTGGGATCCAAACCCAGGACCCTGGTCCAGATTCCCCTCCTGTCCCTTTCCTGAGCCCA GAAGGTCCATGGCAGGCCTTGGTCAGTGGGGAGAGACCTCCCCAATGGTCCACATGCTGA CGAGGTCTTTCTTTTTCTTGTGCAGCCAAAACGCCCCAAACTCGGGTGACCATTCGGACG GTGCGAGTCCGCCGGCCCCCCAAGGGCAAGCACCGGAAATTCAAGCACACGCATGACAAG ACGGCACTGAAGGAGACCCTTGGAGCCTAGGGGCATCGGCAGGAGAGTGTGTGGGCAGGT GAGGGCCAGGCGGGGCAACTGAGGCCCAGAATCCTGTGTTTTCTTCTCTGTGGTCTGTGG ATGGGGTCAGGGGAAAGGATTTTTCCATAGAAAATCCAGCCTCTGAGCCTTGGTCCTCCC TGTCCAGTTATCAGCTGGGGCAGGGTGGGTGGTGGGCTTTGGAGACCCCAGCCCAGCTGT GTCCCAGCATGCCCTAAGAGGATGGGAGGTCTAAATCTCAATCTTCCCAGCCCCTCAATG CCCCCAGCCCTGAGCATTGCTGGAAATCAGGGGTGGCTAGTTGACCCCAGCTCCCTGCCC CTGGCATCGGGGACATATGAACATGGGATGGACCCTCTAGGCTGTCTCTGACCCCTGTGT CTCTCTGCTTGGCCTGCAGGGTTATTTAATATGGTATTTGCTGTATTGCCCCCATGGGGT CCTTGGAGTGATAATATTGTTTCCCTCGTCCGTCTGTCTCGATGCCTGATTCGGACGGCC AATGGTGCTTCCCCCACCCCTCCACGTGTCCGTCCACCCTTCCATCAGCGGGTCTCCTCC CAGCGGCCTCCGGCGTCTTGCCCAGCAGCTCAAGAAGAAAAAGAAGGACTGAACTCCATC GCCATCTTCTTCCCTTAACTCCAAGAACTTGGGATAAGAGTGTGAGAGAGACTGATGGGG TCGCTCTTTGGGGGAAACGGGCTCCTTCCCCTGCACCTGGCCTGGGCCACACCTGAGCGC TGTGGACTGTCCTGAGGAGCCCTGAGGACCTCTCAGCATAGCCTGCCTGATCCCTGAACC CCTGGCCAGCTCTGAGGGGAGGCACCTCCAGGCAGGCCAGGCTGCCTCGGACTCCATGGC TAAGACCACAGACGGGCACACAGACTGGAGAAAACCCCTCCCACGGTGCCCAAACACCAG TCACCTCGTCTCCCTGGTGCCTCTGTGCACAGTGGCTTCTTTTCGTTTTCGTTTTGAAGA CGTGGACTCCTCTTGGTGGGTGTGGCCAGCACACCAAGTGGCTGGGTGCCCTCTCAGGTG GGTTAGAGATGGAGTTTGCTGTTGAGGTGGCTGTAGATGGTGACCTGGGTATCCCCTGCC TCCTGCCACCCCTTCCTCCCCACACTCCACTCTGATTCACCTCTTCCTCTGGTTCCTTTC ATCTCTCTACCTCCACCCTGCATTTTCCTCTTGTCCTGGCCCTTCAGTCTGCTCCACCAA GGGGCTCTTGAACCCCTTATTAAGGCCCCAGATGATCCCAGTCACTCCTCTCTAGGGCAG AAGACTAGAGGCCAGGGCAGCAAGGGACCTGCTCATCATATTCCAACCCAGCCACGACTG CCATGTAAGGTTGTGCAGGGTGTGTACTGCACAAGGACATTGTATGCAGGGAGCACTGTT CACATCATAGATAAAGCTGATTTGTATATTTATTATGACAATTTCTGGCAGATGTAGGTA AAGAGGAAAAGGATCCTTTTCCTAATTCACACAAAGACTCCTTGTGGACTGGCTGTGCCC CTGATGCAGCCTGTGGCTTGGAGTGGCCAAATAGGAGGGAGACTGTGGTAGGGGCAGGGA GGCAACACTGCTGTCCACATGACCTCCATTTCCCAAAGTCCTCTGCTCCAGCAACTGCCC TTCCAGGTGGGTGTGGGACACCTGGGAGAAGGTCTCCAAGGGAGGGTGCAGCCCTCTTGC CCGCACCCCTCCCTGCTTGCACACTTCCCCATCTTTGATCCTTCTGAGCTCCACCTCTGG TGGCTCCTCCTAGGAAACCAGCTCGTGGGCTGGGAATGGGGGAGAGAAGGGAAAAGATCC CCAAGACCCCCTGGGGTGGGATCTGAGCTCCCACCTCCCTTCCCACCTACTGCACTTTCC CCCTTCCCGCCTTCCAAAACCTGCTTCCTTCAGTTTGTAAAGTCGGTGATTATATTTTTG GGGGCTTTCCTTTTATTTTTTAAATGTAAAATTTATTTATATTCCGTATTTAAAGTTGTA AAAAAAAATAACCACAAAACAAAACCAAATGAA OMIM ID 190040