Database of mammalian genes
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Gene
Protein
Transcript
Promoter
Expression
GO/PPI
PubMed
Cross reference
Gene Ontology information for PDGFB (
Homo sapiens
)
(Information is obtained from AmiGO)
ID
Term
Evidence
biological_process
GO:0001568
blood vessel development
IEA
GO:0001666
response to hypoxia
IEA
GO:0001892
embryonic placenta development
IEA
GO:0001892
embryonic placenta development
ISS
GO:0001938
positive regulation of endothelial cell proliferation
IDA
GO:0001938
positive regulation of endothelial cell proliferation
IEA
GO:0002548
monocyte chemotaxis
IDA
GO:0002576
platelet degranulation
TAS
GO:0003104
positive regulation of glomerular filtration
IEA
GO:0003104
positive regulation of glomerular filtration
ISS
GO:0006260
DNA replication
IEA
GO:0006468
protein phosphorylation
IDA
GO:0006929
substrate-dependent cell migration
IEA
GO:0007179
transforming growth factor beta receptor signaling pathway
IEA
GO:0007179
transforming growth factor beta receptor signaling pathway
ISS
GO:0007507
heart development
IEA
GO:0007507
heart development
ISS
GO:0007596
blood coagulation
TAS
GO:0008284
positive regulation of cell proliferation
IDA
GO:0009611
response to wounding
IDA
GO:0009611
response to wounding
NAS
GO:0010512
negative regulation of phosphatidylinositol biosynthetic process
IDA
GO:0010544
negative regulation of platelet activation
IDA
GO:0014068
positive regulation of phosphatidylinositol 3-kinase cascade
IDA
GO:0014070
response to organic cyclic compound
IEA
GO:0014911
positive regulation of smooth muscle cell migration
IDA
GO:0014911
positive regulation of smooth muscle cell migration
IEA
GO:0016049
cell growth
IEA
GO:0018105
peptidyl-serine phosphorylation
IDA
GO:0018108
peptidyl-tyrosine phosphorylation
IDA
GO:0030031
cell projection assembly
IEA
GO:0030036
actin cytoskeleton organization
IEA
GO:0030097
hemopoiesis
IMP
GO:0030168
platelet activation
TAS
GO:0030335
positive regulation of cell migration
IDA
GO:0030336
negative regulation of cell migration
IEA
GO:0031954
positive regulation of protein autophosphorylation
IDA
GO:0032147
activation of protein kinase activity
IDA
GO:0032148
activation of protein kinase B activity
IDA
GO:0032355
response to estradiol stimulus
IEA
GO:0032868
response to insulin stimulus
IEA
GO:0035793
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
IDA
GO:0038001
paracrine signaling
IEA
GO:0038001
paracrine signaling
ISS
GO:0042060
wound healing
IEA
GO:0042127
regulation of cell proliferation
IEA
GO:0042493
response to drug
IEA
GO:0043406
positive regulation of MAP kinase activity
IDA
GO:0043406
positive regulation of MAP kinase activity
IEA
GO:0043410
positive regulation of MAPKKK cascade
IMP
GO:0043536
positive regulation of blood vessel endothelial cell migration
IDA
GO:0043552
positive regulation of phosphatidylinositol 3-kinase activity
IDA
GO:0045737
positive regulation of cyclin-dependent protein kinase activity
IDA
GO:0045740
positive regulation of DNA replication
IDA
GO:0045743
positive regulation of fibroblast growth factor receptor signaling pathway
IEA
GO:0045840
positive regulation of mitosis
IDA
GO:0045892
negative regulation of transcription, DNA-dependent
IDA
GO:0045893
positive regulation of transcription, DNA-dependent
IDA
GO:0045893
positive regulation of transcription, DNA-dependent
IEA
GO:0048008
platelet-derived growth factor receptor signaling pathway
IDA
GO:0048008
platelet-derived growth factor receptor signaling pathway
IEA
GO:0048146
positive regulation of fibroblast proliferation
IDA
GO:0048661
positive regulation of smooth muscle cell proliferation
IDA
GO:0048661
positive regulation of smooth muscle cell proliferation
IEA
GO:0050730
regulation of peptidyl-tyrosine phosphorylation
IEA
GO:0050731
positive regulation of peptidyl-tyrosine phosphorylation
IDA
GO:0050921
positive regulation of chemotaxis
IDA
GO:0051781
positive regulation of cell division
IEA
GO:0060326
cell chemotaxis
IDA
GO:0060445
branching involved in salivary gland morphogenesis
IEA
GO:0060664
epithelial cell proliferation involved in salivary gland morphogenesis
IEA
GO:0061098
positive regulation of protein tyrosine kinase activity
IDA
GO:0070374
positive regulation of ERK1 and ERK2 cascade
IDA
GO:0071506
cellular response to mycophenolic acid
IEA
GO:0071506
cellular response to mycophenolic acid
ISS
GO:0072126
positive regulation of glomerular mesangial cell proliferation
IDA
GO:0072255
metanephric glomerular mesangial cell development
IEA
GO:0072255
metanephric glomerular mesangial cell development
ISS
GO:0072262
metanephric glomerular mesangial cell proliferation involved in metanephros development
IEA
GO:0072264
metanephric glomerular endothelium development
IEA
GO:0072593
reactive oxygen species metabolic process
IMP
GO:0090280
positive regulation of calcium ion import
IDA
GO:2000379
positive regulation of reactive oxygen species metabolic process
IDA
GO:2000573
positive regulation of DNA biosynthetic process
IDA
GO:2000591
positive regulation of metanephric mesenchymal cell migration
IDA
GO:2000591
positive regulation of metanephric mesenchymal cell migration
IEA
cellular_component
GO:0000139
Golgi membrane
TAS
GO:0005576
extracellular region
NAS
GO:0005576
extracellular region
TAS
GO:0005737
cytoplasm
IEA
GO:0005737
cytoplasm
ISS
GO:0005788
endoplasmic reticulum lumen
TAS
GO:0009986
cell surface
IDA
GO:0016020
membrane
IEA
GO:0016323
basolateral plasma membrane
IEA
GO:0016323
basolateral plasma membrane
ISS
GO:0031093
platelet alpha granule lumen
TAS
molecular_function
GO:0004713
protein tyrosine kinase activity
TAS
GO:0005161
platelet-derived growth factor receptor binding
IDA
GO:0005161
platelet-derived growth factor receptor binding
IEA
GO:0005161
platelet-derived growth factor receptor binding
IPI
GO:0005161
platelet-derived growth factor receptor binding
NAS
GO:0005515
protein binding
IPI
GO:0005518
collagen binding
IDA
GO:0008083
growth factor activity
IEA
GO:0016176
superoxide-generating NADPH oxidase activator activity
IDA
GO:0042803
protein homodimerization activity
IDA
GO:0043498
cell surface binding
IDA
GO:0043498
cell surface binding
IEA
GO:0043499
eukaryotic cell surface binding
IDA
GO:0046982
protein heterodimerization activity
IPI
GO:0048407
platelet-derived growth factor binding
IPI
Protein-protein interaction details for PDGFB (
Homo sapiens
)
(Information is obtained from BioGRID)
Interacting human protein
Experiment
Type
PubMed ID
PDGFRA
Reconstituted Complex
physical
2544881
LRP1
Reconstituted Complex
physical
11854294
SPARC
Reconstituted Complex
physical
1311092
PDAP1
Co-purification
physical
8780057
THBS1
Reconstituted Complex
physical
9334164
PDGFB
Co-crystal Structure
physical
1396586
HSPG2
Reconstituted Complex
physical
9692901