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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for PDGFB (Homo sapiens)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0001568blood vessel developmentIEA
GO:0001666response to hypoxiaIEA
GO:0001892embryonic placenta developmentIEA
GO:0001892embryonic placenta developmentISS
GO:0001938positive regulation of endothelial cell proliferationIDA
GO:0001938positive regulation of endothelial cell proliferationIEA
GO:0002548monocyte chemotaxisIDA
GO:0002576platelet degranulationTAS
GO:0003104positive regulation of glomerular filtrationIEA
GO:0003104positive regulation of glomerular filtrationISS
GO:0006260DNA replicationIEA
GO:0006468protein phosphorylationIDA
GO:0006929substrate-dependent cell migrationIEA
GO:0007179transforming growth factor beta receptor signaling pathwayIEA
GO:0007179transforming growth factor beta receptor signaling pathwayISS
GO:0007507heart developmentIEA
GO:0007507heart developmentISS
GO:0007596blood coagulationTAS
GO:0008284positive regulation of cell proliferationIDA
GO:0009611response to woundingIDA
GO:0009611response to woundingNAS
GO:0010512negative regulation of phosphatidylinositol biosynthetic processIDA
GO:0010544negative regulation of platelet activationIDA
GO:0014068positive regulation of phosphatidylinositol 3-kinase cascadeIDA
GO:0014070response to organic cyclic compoundIEA
GO:0014911positive regulation of smooth muscle cell migrationIDA
GO:0014911positive regulation of smooth muscle cell migrationIEA
GO:0016049cell growthIEA
GO:0018105peptidyl-serine phosphorylationIDA
GO:0018108peptidyl-tyrosine phosphorylationIDA
GO:0030031cell projection assemblyIEA
GO:0030036actin cytoskeleton organizationIEA
GO:0030097hemopoiesisIMP
GO:0030168platelet activationTAS
GO:0030335positive regulation of cell migrationIDA
GO:0030336negative regulation of cell migrationIEA
GO:0031954positive regulation of protein autophosphorylationIDA
GO:0032147activation of protein kinase activityIDA
GO:0032148activation of protein kinase B activityIDA
GO:0032355response to estradiol stimulusIEA
GO:0032868response to insulin stimulusIEA
GO:0035793positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwayIDA
GO:0038001paracrine signalingIEA
GO:0038001paracrine signalingISS
GO:0042060wound healingIEA
GO:0042127regulation of cell proliferationIEA
GO:0042493response to drugIEA
GO:0043406positive regulation of MAP kinase activityIDA
GO:0043406positive regulation of MAP kinase activityIEA
GO:0043410positive regulation of MAPKKK cascadeIMP
GO:0043536positive regulation of blood vessel endothelial cell migrationIDA
GO:0043552positive regulation of phosphatidylinositol 3-kinase activityIDA
GO:0045737positive regulation of cyclin-dependent protein kinase activityIDA
GO:0045740positive regulation of DNA replicationIDA
GO:0045743positive regulation of fibroblast growth factor receptor signaling pathwayIEA
GO:0045840positive regulation of mitosisIDA
GO:0045892negative regulation of transcription, DNA-dependentIDA
GO:0045893positive regulation of transcription, DNA-dependentIDA
GO:0045893positive regulation of transcription, DNA-dependentIEA
GO:0048008platelet-derived growth factor receptor signaling pathwayIDA
GO:0048008platelet-derived growth factor receptor signaling pathwayIEA
GO:0048146positive regulation of fibroblast proliferationIDA
GO:0048661positive regulation of smooth muscle cell proliferationIDA
GO:0048661positive regulation of smooth muscle cell proliferationIEA
GO:0050730regulation of peptidyl-tyrosine phosphorylationIEA
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIDA
GO:0050921positive regulation of chemotaxisIDA
GO:0051781positive regulation of cell divisionIEA
GO:0060326cell chemotaxisIDA
GO:0060445branching involved in salivary gland morphogenesisIEA
GO:0060664epithelial cell proliferation involved in salivary gland morphogenesisIEA
GO:0061098positive regulation of protein tyrosine kinase activityIDA
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDA
GO:0071506cellular response to mycophenolic acidIEA
GO:0071506cellular response to mycophenolic acidISS
GO:0072126positive regulation of glomerular mesangial cell proliferationIDA
GO:0072255metanephric glomerular mesangial cell developmentIEA
GO:0072255metanephric glomerular mesangial cell developmentISS
GO:0072262metanephric glomerular mesangial cell proliferation involved in metanephros developmentIEA
GO:0072264metanephric glomerular endothelium developmentIEA
GO:0072593reactive oxygen species metabolic processIMP
GO:0090280positive regulation of calcium ion importIDA
GO:2000379positive regulation of reactive oxygen species metabolic processIDA
GO:2000573positive regulation of DNA biosynthetic processIDA
GO:2000591positive regulation of metanephric mesenchymal cell migrationIDA
GO:2000591positive regulation of metanephric mesenchymal cell migrationIEA
cellular_component
GO:0000139Golgi membraneTAS
GO:0005576extracellular regionNAS
GO:0005576extracellular regionTAS
GO:0005737cytoplasmIEA
GO:0005737cytoplasmISS
GO:0005788endoplasmic reticulum lumenTAS
GO:0009986cell surfaceIDA
GO:0016020membraneIEA
GO:0016323basolateral plasma membraneIEA
GO:0016323basolateral plasma membraneISS
GO:0031093platelet alpha granule lumenTAS
molecular_function
GO:0004713protein tyrosine kinase activityTAS
GO:0005161platelet-derived growth factor receptor bindingIDA
GO:0005161platelet-derived growth factor receptor bindingIEA
GO:0005161platelet-derived growth factor receptor bindingIPI
GO:0005161platelet-derived growth factor receptor bindingNAS
GO:0005515protein bindingIPI
GO:0005518collagen bindingIDA
GO:0008083growth factor activityIEA
GO:0016176superoxide-generating NADPH oxidase activator activityIDA
GO:0042803protein homodimerization activityIDA
GO:0043498cell surface bindingIDA
GO:0043498cell surface bindingIEA
GO:0043499eukaryotic cell surface bindingIDA
GO:0046982protein heterodimerization activityIPI
GO:0048407platelet-derived growth factor bindingIPI

Protein-protein interaction details for PDGFB (Homo sapiens)
(Information is obtained from BioGRID)
Interacting human proteinExperimentTypePubMed ID
PDGFRAReconstituted Complexphysical2544881
LRP1Reconstituted Complexphysical11854294
SPARCReconstituted Complexphysical1311092
PDAP1Co-purificationphysical8780057
THBS1Reconstituted Complexphysical9334164
PDGFBCo-crystal Structurephysical1396586
HSPG2Reconstituted Complexphysical9692901