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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PLCG1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5335
Official gene symbolPLCG1
Full namephospholipase C, gamma 1
Aliases,NCKAP3,PLC-II,PLC1,PLC148,PLCgamma1,
Gene summaryThe protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 20   Locus: 20q12-q13.1
Gene position39766161 - 39804357  Map Viewer
Gene orientationplus
Gene size38197 bp
Gene sequence
OMIM ID172420