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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for PLCG1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0007165 signal transduction NAS GO:0007165 signal transduction TAS GO:0007173 epidermal growth factor receptor signaling pathway TAS GO:0007202 activation of phospholipase C activity TAS GO:0007411 axon guidance TAS GO:0007596 blood coagulation TAS GO:0008543 fibroblast growth factor receptor signaling pathway TAS GO:0009395 phospholipid catabolic process IEA GO:0010634 positive regulation of epithelial cell migration IMP GO:0016042 lipid catabolic process IEA GO:0035556 intracellular signal transduction IEA GO:0043536 positive regulation of blood vessel endothelial cell migration IDA GO:0044419 interspecies interaction between organisms IEA GO:0045766 positive regulation of angiogenesis IDA GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0050852 T cell receptor signaling pathway TAS GO:0050900 leukocyte migration TAS GO:0071364 cellular response to epidermal growth factor stimulus IDA cellular_component GO:0001726 ruffle IDA GO:0005737 cytoplasm IDA GO:0005829 cytosol IDA GO:0005829 cytosol TAS GO:0005886 plasma membrane IDA GO:0005886 plasma membrane TAS GO:0030027 lamellipodium IDA molecular_function GO:0004435 phosphatidylinositol phospholipase C activity IDA GO:0004435 phosphatidylinositol phospholipase C activity TAS GO:0005057 receptor signaling protein activity NAS GO:0005509 calcium ion binding IEA GO:0005515 protein binding IPI GO:0016787 hydrolase activity IEA

Protein-protein interaction details for PLCG1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID EEF1A1 Two-hybrid physical 11886851 GIT1 Affinity Capture-Western physical 14523024 GIT1 Affinity Capture-Western physical 14523024 GIT1 Reconstituted Complex physical 14523024 SELE Affinity Capture-Western physical 12960351 DGKZ Affinity Capture-Western physical 12890670 PLD2 Affinity Capture-Western physical 12646582 PLD2 Reconstituted Complex physical 12646582 SRC Affinity Capture-Western physical 7510703 WAS Reconstituted Complex physical 8805332 EEF1A1 Reconstituted Complex physical 11886851 EEF1A1 Far Western physical 11886851 EEF1A1 Affinity Capture-Western physical 11886851 EEF1A1 Affinity Capture-Western physical 11886851 VAV1 Affinity Capture-Western physical 9891995 VAV1 Affinity Capture-Western physical 9891995 KHDRBS1 Affinity Capture-Western physical 11960376 GAB1 Affinity Capture-Western physical 11507676 GAB1 Affinity Capture-Western physical 11507676 LCP2 Affinity Capture-Western physical 11390650 LCP2 Reconstituted Complex physical 11390650 SH3BP2 Reconstituted Complex physical 9846481 DOK1 Reconstituted Complex physical 11071635 KIT Reconstituted Complex physical 11071635 GRB2 Affinity Capture-Western physical 9281317 GRB2 Reconstituted Complex physical 9281317 SHC1 Affinity Capture-Western physical 8662733 NTRK1 Reconstituted Complex physical 1715690 KHDRBS1 Affinity Capture-Western physical 9743338 RASA1 Affinity Capture-Western physical 9743338 SH3BP2 Far Western physical 11390470 SYK Affinity Capture-Western physical 7831290 SHB Affinity Capture-Western physical 10488157 LAT Co-fractionation physical 9729044 RHOA Affinity Capture-Western physical 12071848 RHOA Reconstituted Complex physical 12071848 PKN2 Reconstituted Complex physical 8910519 ALK Affinity Capture-Western physical 11888936 LAT Affinity Capture-Western physical 11368773 LAT Reconstituted Complex physical 11368773 KHDRBS1 Reconstituted Complex physical 10467411 KHDRBS1 Affinity Capture-Western physical 10467411 PDGFA Affinity Capture-Western physical 8443409 PDGFRB Affinity Capture-Western physical 8443409 NTRK1 Two-hybrid physical 9856458 PAK1 Reconstituted Complex physical 12085993 PTK2 Affinity Capture-Western physical 10430888 PRKD1 Affinity Capture-Western physical 8885868 ITK Reconstituted Complex physical 10586033 ITK Affinity Capture-Western physical 10586033 SYNCRIP Reconstituted Complex physical 9341187 FGFR1 Two-hybrid physical 9660748 GRB2 Affinity Capture-Western physical 7629168 ZAP70 Affinity Capture-Western physical 7629168 PDGFRA Affinity Capture-Western physical 7535778 PDGFRA Reconstituted Complex physical 7535778 ARHGAP32 Affinity Capture-Western physical 12454018 NTRK1 Reconstituted Complex physical 10092678 NTRK2 Reconstituted Complex physical 10092678 NTRK3 Reconstituted Complex physical 10092678 LAT2 Affinity Capture-Western physical 12514734 SH2B3 Affinity Capture-Western physical 8649391 RET Reconstituted Complex physical 8628282 TRPM7 Reconstituted Complex physical 11941371 TNK1 Reconstituted Complex physical 10873601 KIT Reconstituted Complex physical 7536744 ERBB2 Affinity Capture-Western physical 1676673 ERBB2 Co-fractionation physical 1683701 WAS Reconstituted Complex physical 8824280 FLT1 Reconstituted Complex physical 9398617 KDR Reconstituted Complex physical 9398617 FLT1 Two-hybrid physical 9398617 CBL Far Western physical 12061819 CBL Reconstituted Complex physical 12061819 CBL Affinity Capture-Western physical 12061819 EGFR Affinity Capture-Western physical 12061819 CBL Reconstituted Complex physical 9712732 GNB2L1 Far Western physical 8290562 ITK Biochemical Activity physical 12163161 IRS2 Affinity Capture-Western physical 9535722 IRS2 Affinity Capture-Western physical 9535722 GAB1 Affinity Capture-Western physical 8596638 GAB1 Far Western physical 8596638 PTPRJ Biochemical Activity physical 11259588 PICALM Reconstituted Complex physical 10926122 SOS1 Reconstituted Complex physical 10913276 SOS1 Reconstituted Complex physical 10913276 SOS1 Affinity Capture-Western physical 10913276 SOS1 Affinity Capture-Western physical 10913276 PECAM1 Reconstituted Complex physical 10350061 PECAM1 Far Western physical 10350061 CD22 Affinity Capture-Western physical 8627166 GHR Reconstituted Complex physical 9632636 SOS2 Two-hybrid physical 10940929 SOS1 Affinity Capture-Western physical 10940929 SOS2 Affinity Capture-Western physical 10940929 GRB2 Affinity Capture-Western physical 10940929 TUB Reconstituted Complex physical 10455176 TUB Affinity Capture-Western physical 10455176 LAT Affinity Capture-Western physical 9489702 MST1R Affinity Capture-Western physical 8918464 EGFR Affinity Capture-Western physical 9207933 NTRK1 Two-hybrid physical 10708759 ABL1 Reconstituted Complex physical 10708759 GAB2 Reconstituted Complex physical 10391903 GSN Reconstituted Complex physical 9164868 NTRK2 Two-hybrid physical 12074588 BAG3 Affinity Capture-Western physical 10980614 BAG3 Reconstituted Complex physical 10980614 LTK Affinity Capture-Western physical 8084603 PARK2 Affinity Capture-Western physical 18671761 UBC Affinity Capture-Western physical 18671761 EPHB2 Two-hybrid physical 9632142 PLXNB1 Affinity Capture-Western physical 19805522 PLXNB1 Affinity Capture-Western physical 19805522 PLXNB2 Affinity Capture-Western physical 19805522 ARHGEF2 Affinity Capture-Western physical 19805522 UBC Affinity Capture-Western physical 17372230 CBL Affinity Capture-Western physical 17372230 ALK Affinity Capture-MS physical 14968112 ALK Affinity Capture-Western physical 14968112 CAMK2A Affinity Capture-Western physical 18292392 EPOR PCA physical 15644415 BAG3 Reconstituted Complex physical 21233200