Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PLCG2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5336
Official gene symbolPLCG2
Full namephospholipase C, gamma 2 (phosphatidylinositol-specific)
Aliases,-,
Gene summaryEnzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3.[supplied by OMIM]
LocationChromosome: 16   Locus: 16q24.1
Gene position81812930 - 81991899  Map Viewer
Gene orientationplus
Gene size178970 bp
Gene sequence