Entrez gene ID | | 5336 |
Official gene symbol | | PLCG2 |
Full name | | phospholipase C, gamma 2 (phosphatidylinositol-specific) |
Aliases | | ,-, |
Gene summary | | Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3.[supplied by OMIM] |
Location | | Chromosome: 16 Locus: 16q24.1 |
Gene position | | 81812930 - 81991899 Map Viewer |
Gene orientation | | plus |
Gene size | | 178970 bp |
Gene sequence |
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