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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PPM1A (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5494
Official gene symbolPPM1A
Full nameprotein phosphatase, Mg2+/Mn2+ dependent, 1A
Aliases,FLJ42306,MGC9201,PP2C-ALPHA,PP2CA,PP2Calpha,
Gene summaryThe protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]
LocationChromosome: 14   Locus: 14q23.1
Gene position60712470 - 60765805  Map Viewer
Gene orientationplus
Gene size53336 bp
Gene sequence
OMIM ID606108