Entrez gene ID | | 5599 |
Official gene symbol | | MAPK8 |
Full name | | mitogen-activated protein kinase 8 |
Aliases | | ,JNK,JNK1,JNK1A2,JNK21B1/2,PRKM8,SAPK1, |
Gene summary | | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] |
Location | | Chromosome: 10 Locus: 10q11.22 |
Gene position | | 49609687 - 49643183 Map Viewer |
Gene orientation | | plus |
Gene size | | 33497 bp |
Gene sequence |
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OMIM ID | | 601158 |
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