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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MAPK8 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5599
Official gene symbolMAPK8
Full namemitogen-activated protein kinase 8
Aliases,JNK,JNK1,JNK1A2,JNK21B1/2,PRKM8,SAPK1,
Gene summaryThe protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
LocationChromosome: 10   Locus: 10q11.22
Gene position49609687 - 49643183  Map Viewer
Gene orientationplus
Gene size33497 bp
Gene sequence
OMIM ID601158