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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for MAPK8 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001503 ossification IEA GO:0002224 toll-like receptor signaling pathway TAS GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS GO:0006915 apoptosis TAS GO:0006950 response to stress TAS GO:0007254 JNK cascade IDA GO:0007254 JNK cascade TAS GO:0007258 JUN phosphorylation IDA GO:0008063 Toll signaling pathway TAS GO:0008624 induction of apoptosis by extracellular signals TAS GO:0008629 induction of apoptosis by intracellular signals TAS GO:0008633 activation of pro-apoptotic gene products TAS GO:0009411 response to UV IDA GO:0018105 peptidyl-serine phosphorylation IDA GO:0018107 peptidyl-threonine phosphorylation IDA GO:0018107 peptidyl-threonine phosphorylation IEA GO:0018107 peptidyl-threonine phosphorylation IMP GO:0031063 regulation of histone deacetylation IMP GO:0031558 induction of apoptosis in response to chemical stimulus IEA GO:0032091 negative regulation of protein binding IDA GO:0032880 regulation of protein localization IDA GO:0034130 toll-like receptor 1 signaling pathway TAS GO:0034134 toll-like receptor 2 signaling pathway TAS GO:0034138 toll-like receptor 3 signaling pathway TAS GO:0034142 toll-like receptor 4 signaling pathway TAS GO:0043066 negative regulation of apoptosis IDA GO:0045087 innate immune response TAS GO:0046686 response to cadmium ion IEA GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0051090 regulation of sequence-specific DNA binding transcription factor activity TAS GO:0051403 stress-activated MAPK cascade TAS GO:0071260 cellular response to mechanical stimulus IEP GO:0090045 positive regulation of deacetylase activity IMP GO:2000017 positive regulation of determination of dorsal identity IEA cellular_component GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005654 nucleoplasm TAS GO:0005737 cytoplasm IEA GO:0005739 mitochondrion IEA GO:0005829 cytosol IEA GO:0005829 cytosol TAS molecular_function GO:0000166 nucleotide binding IEA GO:0004672 protein kinase activity IEA GO:0004674 protein serine/threonine kinase activity IDA GO:0004674 protein serine/threonine kinase activity IEA GO:0004705 JUN kinase activity IDA GO:0004705 JUN kinase activity IEA GO:0004707 MAP kinase activity IEA GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0016772 transferase activity, transferring phosphorus-containing groups IEA GO:0035033 histone deacetylase regulator activity IMP GO:0042826 histone deacetylase binding IPI

Protein-protein interaction details for MAPK8 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID IRS1 Two-hybrid physical 11606564 DUSP10 Two-hybrid physical 10391943 TNFRSF10B Co-purification physical 15659383 FADD Co-purification physical 15659383 FASLG Co-purification physical 15659383 BID Co-purification physical 15659383 EZR Co-purification physical 15659383 RHOA Co-purification physical 15659383 ARHGDIA Co-purification physical 15659383 FAS Co-purification physical 15659383 MSN Co-purification physical 15659383 CASP10 Co-purification physical 15659383 CASP8 Co-purification physical 15659383 TNFRSF1A Co-purification physical 15659383 JUN Biochemical Activity physical 14633987 SPIB Co-purification physical 8632909 SPIB Biochemical Activity physical 8632909 SPI1 Biochemical Activity physical 8632909 SH3BP5 Reconstituted Complex physical 12167088 SH3BP5 Two-hybrid physical 12167088 SH3BP5 Biochemical Activity physical 12167088 SH3BP5 Co-localization physical 12167088 JUN Biochemical Activity physical 9774977 DUSP22 Biochemical Activity physical 11346645 DUSP22 Affinity Capture-Western physical 11346645 MAP3K1 Affinity Capture-Western physical 9405400 MAP3K1 Reconstituted Complex physical 9405400 MAP3K1 Biochemical Activity physical 9405400 MAP3K1 Affinity Capture-Western physical 9405400 IKBKAP Two-hybrid physical 12058026 IKBKAP Affinity Capture-Western physical 12058026 IKBKAP Reconstituted Complex physical 12058026 IKBKAP Biochemical Activity physical 12058026 PRKD1 Affinity Capture-Western physical 11948398 ATF2 Reconstituted Complex physical 7535770 SPAG9 Affinity Capture-Western physical 12391307 MAP2K4 Reconstituted Complex physical 12391307 CRK Affinity Capture-Western physical 11432831 BCAR1 Affinity Capture-Western physical 11432831 CRK Reconstituted Complex physical 11432831 JUN Biochemical Activity physical 8137421 JUN Reconstituted Complex physical 8137421 SNCG Affinity Capture-Western physical 12121974 SNCA Affinity Capture-Western physical 12121974 IRS1 Affinity Capture-Western physical 10722755 IRS1 Reconstituted Complex physical 10722755 JUN Reconstituted Complex physical 12052834 JUND Reconstituted Complex physical 12052834 SH2D3A Phenotypic Enhancement genetic 10187783 MAPK8IP1 Affinity Capture-Western physical 9733513 MAP2K4 Reconstituted Complex physical 11707464 JUN Reconstituted Complex physical 11479302 MAPK8IP3 Reconstituted Complex physical 10523642 PAX2 Biochemical Activity physical 11700324 MAPK8IP1 Affinity Capture-Western physical 11700324 PRKDC Biochemical Activity physical 11749722 TP53 Affinity Capture-Western physical 9393873 MAPK8IP3 Reconstituted Complex physical 10629060 MAPK8IP3 Biochemical Activity physical 10629060 JUN Two-hybrid physical 8621542 REL Two-hybrid physical 8621542 REL Affinity Capture-Western physical 8621542 JUNB Affinity Capture-Western physical 9405416 ATF2 Affinity Capture-Western physical 9405416 DUSP16 Affinity Capture-Western physical 11489891 ETV1 Biochemical Activity physical 11551945 DUSP10 Biochemical Activity physical 10391943 DUSP4 Reconstituted Complex physical 11387337 JUN Reconstituted Complex physical 8586671 ELK1 Biochemical Activity physical 8586671 JUN Biochemical Activity physical 8586671 DUSP1 Two-hybrid physical 11278799 DUSP1 Affinity Capture-Western physical 11278799 ATF2 Biochemical Activity physical 11279118 MAP2K4 Biochemical Activity physical 11279118 MAP2K7 Biochemical Activity physical 9207092 ATF2 Biochemical Activity physical 9207092 MAP2K7 Biochemical Activity physical 9207092 JUN Biochemical Activity physical 9207092 MAP2K4 Phenotypic Enhancement genetic 9207092 MAP2K7 Phenotypic Enhancement genetic 9207092 GSTP1 Affinity Capture-Western physical 11279197 GSTP1 Reconstituted Complex physical 11279197 MYC Biochemical Activity physical 10551811 MYC Reconstituted Complex physical 10551811 MYC Affinity Capture-Western physical 10551811 MAP2K4 Affinity Capture-Western physical 10713157 MAP2K7 Affinity Capture-Western physical 10713157 MAP3K2 Affinity Capture-Western physical 10713157 MAP3K2 Co-fractionation physical 10713157 PDPK1 Reconstituted Complex physical 10357815 NR4A1 Biochemical Activity physical 17023523 CEBPA Reconstituted Complex physical 16983342 JUN Reconstituted Complex physical 16983342 CEBPA Affinity Capture-Western physical 16983342 CEBPA Biochemical Activity physical 16983342 CDKN1A Affinity Capture-Western physical 20102411 CDKN1A Affinity Capture-Western physical 20102411 SIRT1 Affinity Capture-Western physical 20027304 SIRT1 Biochemical Activity physical 20027304 JUN Biochemical Activity physical 16740711 H2AFX Reconstituted Complex physical 17145805 TP53 Reconstituted Complex physical 15538975 TP53 Reconstituted Complex physical 15538975 HDAC9 Affinity Capture-Western physical 16611996 HDAC9 Reconstituted Complex physical 16611996 HDAC1 Affinity Capture-Western physical 16611996 JUND Affinity Capture-Western physical 16264271 TFCP2 Biochemical Activity physical 15857981 NFATC2 Affinity Capture-Western physical 15184502 NFE2 Biochemical Activity physical 19966288 TP53 Biochemical Activity physical 9724739 H2AFX Affinity Capture-Western physical 20512932 ATF2 Affinity Capture-Western physical 12958075 ATF2 Biochemical Activity physical 12958075 TP53 Biochemical Activity physical 19651615 PIAS2 Affinity Capture-MS physical 19815509 PIAS2 Affinity Capture-Western physical 19815509 PIAS2 Two-hybrid physical 19815509 PIAS2 Reconstituted Complex physical 19815509 LOC90462 Two-hybrid physical 21900206 DUSP8 Two-hybrid physical 21900206 FAM193B Two-hybrid physical 21900206 BMPR2 Two-hybrid physical 21900206 PNRC1 Two-hybrid physical 21900206 HSPA8 Two-hybrid physical 21900206 CCDC88C Two-hybrid physical 21900206 ZNF219 Two-hybrid physical 21900206 RBM15 Two-hybrid physical 21900206 SCAND1 Two-hybrid physical 21900206 JUN Biochemical Activity physical 10419510 JUN Reconstituted Complex physical 10419510 STAT3 Biochemical Activity physical 10521505 KRT8 Affinity Capture-Western physical 11781324 NCOA3 Biochemical Activity physical 15383283 CDT1 Affinity Capture-Western physical 21930785