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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MASP1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5648
Official gene symbolMASP1
Full namemannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
Aliases,CRARF,CRARF1,DKFZp686I01199,FLJ26383,MAP1,MASP,MASP3,MGC126283,MGC126284,PRSS5,RaRF,
Gene summaryThis gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.
LocationChromosome: 3   Locus: 3q27-q28
Gene position187009810 - 186933873  Map Viewer
Gene orientationminus
Gene size75938 bp
Gene sequence
OMIM ID600521