Entrez gene ID | | 5702 |
Official gene symbol | | PSMC3 |
Full name | | proteasome (prosome, macropain) 26S subunit, ATPase, 3 |
Aliases | | ,MGC8487,TBP1, |
Gene summary | | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11p12-p13 |
Gene position | | 47448024 - 47440320 Map Viewer |
Gene orientation | | minus |
Gene size | | 7705 bp |
Gene sequence |
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OMIM ID | | 186852 |
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