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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PTEN (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5728
Official gene symbolPTEN
Full namephosphatase and tensin homolog
Aliases,10q23del,BZS,DEC,MGC11227,MHAM,MMAC1,PTEN1,TEP1,
Gene summaryThis gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq]
LocationChromosome: 10   Locus: 10q23.3
Gene position89623195 - 89728532  Map Viewer
Gene orientationplus
Gene size105338 bp
Gene sequence
OMIM ID601728