Entrez gene ID | | 5728 |
Official gene symbol | | PTEN |
Full name | | phosphatase and tensin homolog |
Aliases | | ,10q23del,BZS,DEC,MGC11227,MHAM,MMAC1,PTEN1,TEP1, |
Gene summary | | This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq] |
Location | | Chromosome: 10 Locus: 10q23.3 |
Gene position | | 89623195 - 89728532 Map Viewer |
Gene orientation | | plus |
Gene size | | 105338 bp |
Gene sequence |
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OMIM ID | | 601728 |
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