Home

Search

Browse

Statistics

User guide

FAQs

Links

Questions

Contribute

Download

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for PTEN (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000079 regulation of cyclin-dependent protein kinase activity TAS GO:0001525 angiogenesis IEA GO:0001933 negative regulation of protein phosphorylation IDA GO:0002902 regulation of B cell apoptosis IEA GO:0006470 protein dephosphorylation IDA GO:0006470 protein dephosphorylation TAS GO:0006629 lipid metabolic process IEA GO:0006917 induction of apoptosis ISS GO:0007092 activation of mitotic anaphase-promoting complex activity IDA GO:0007417 central nervous system development ISS GO:0007507 heart development ISS GO:0008283 cell proliferation TAS GO:0008284 positive regulation of cell proliferation IEA GO:0008285 negative regulation of cell proliferation IDA GO:0008285 negative regulation of cell proliferation IMP GO:0008543 fibroblast growth factor receptor signaling pathway TAS GO:0010975 regulation of neuron projection development ISS GO:0016477 cell migration ISS GO:0030336 negative regulation of cell migration IMP GO:0031647 regulation of protein stability IMP GO:0031658 negative regulation of cyclin-dependent protein kinase activity involved in G1/S IDA GO:0033032 regulation of myeloid cell apoptosis IEA GO:0035335 peptidyl-tyrosine dephosphorylation IDA GO:0043066 negative regulation of apoptosis IEA GO:0043542 endothelial cell migration IEA GO:0046855 inositol phosphate dephosphorylation IDA GO:0046856 phosphatidylinositol dephosphorylation IDA GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0048015 phosphatidylinositol-mediated signaling TAS GO:0048738 cardiac muscle tissue development IEA GO:0050680 negative regulation of epithelial cell proliferation IEA GO:0050821 protein stabilization IDA GO:0050852 T cell receptor signaling pathway TAS GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IMP GO:0051895 negative regulation of focal adhesion assembly IMP GO:0051898 negative regulation of protein kinase B signaling cascade IMP GO:0060070 canonical Wnt receptor signaling pathway IDA GO:0060736 prostate gland growth IEA GO:0090344 negative regulation of cell aging IEA GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA GO:2000134 negative regulation of G1/S transition of mitotic cell cycle IDA cellular_component GO:0005634 nucleus IDA GO:0005737 cytoplasm IDA GO:0005737 cytoplasm TAS GO:0005829 cytosol TAS GO:0009898 internal side of plasma membrane IDA GO:0016605 PML body IEA GO:0043209 myelin sheath IEA GO:0043220 Schmidt-Lanterman incisure IEA molecular_function GO:0000287 magnesium ion binding IEA GO:0004438 phosphatidylinositol-3-phosphatase activity IDA GO:0004721 phosphoprotein phosphatase activity IDA GO:0004722 protein serine/threonine phosphatase activity IDA GO:0004725 protein tyrosine phosphatase activity IDA GO:0005515 protein binding IPI GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA GO:0008289 lipid binding IEA GO:0010997 anaphase-promoting complex binding IPI GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IDA GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity TAS GO:0016787 hydrolase activity IEA GO:0019899 enzyme binding IPI GO:0030165 PDZ domain binding IPI GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity IDA GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity IDA

Protein-protein interaction details for PTEN (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID AR Reconstituted Complex physical 15205473 AR Affinity Capture-Western physical 15205473 ESR1 Reconstituted Complex physical 15205473 UBE2L3 Affinity Capture-Western physical 12620973 UBE2I Affinity Capture-Western physical 12620973 TP53 Affinity Capture-Western physical 12620407 TP53 Affinity Capture-Western physical 12620407 CSNK2A1 Biochemical Activity physical 12297295 CSNK2A2 Biochemical Activity physical 12297295 CSNK2A1 Reconstituted Complex physical 12297295 CSNK2A2 Reconstituted Complex physical 12297295 UTP14A Two-hybrid physical 16169070 ANG Two-hybrid physical 16169070 CHGB Two-hybrid physical 16169070 COPS6 Two-hybrid physical 16169070 HBA1 Two-hybrid physical 16169070 PTK2 Affinity Capture-Western physical 10400703 MVP Two-hybrid physical 12177006 MVP Affinity Capture-Western physical 12177006 MVP Reconstituted Complex physical 12177006 MAGI3 Two-hybrid physical 10748157 MAGI3 Reconstituted Complex physical 10748157 MAGI3 Affinity Capture-Western physical 10748157 CAV1 Affinity Capture-Western physical 12176037 PXN Affinity Capture-Western physical 11857088 PTK2 Affinity Capture-Western physical 11857088 NEDD4 Biochemical Activity physical 18498243 NEDD4 Reconstituted Complex physical 18498243 UBC Reconstituted Complex physical 18498243 UBC Affinity Capture-Western physical 12743124 UBC Affinity Capture-Western physical 20534535 NDFIP1 Affinity Capture-Western physical 20534535 NDFIP2 Affinity Capture-Western physical 20534535 XIAP Affinity Capture-Western physical 19473982 XIAP Affinity Capture-Western physical 19473982 XIAP Biochemical Activity physical 19473982 WWP1 Affinity Capture-Western physical 21532586 WWP1 Reconstituted Complex physical 21532586 UBC Affinity Capture-Western physical 21532586 PTK2 Affinity Capture-Western physical 15717329 CASP8 Affinity Capture-Western physical 15717329 CCNE2 Affinity Capture-Western physical 15717329 IRS4 Affinity Capture-Western physical 15717329 PPP2R4 Affinity Capture-Western physical 15717329 WNT4 Affinity Capture-MS physical 15717329 QRFPR Affinity Capture-MS physical 15717329 ARHGAP26 Affinity Capture-MS physical 15717329 G3BP2 Affinity Capture-MS physical 15717329 CASP8 Affinity Capture-MS physical 15717329 CENPC1 Affinity Capture-MS physical 15717329 DBF4B Affinity Capture-MS physical 15717329 GPR113 Affinity Capture-MS physical 15717329 INHBE Affinity Capture-MS physical 15717329 GFRA2 Affinity Capture-MS physical 15717329 SMTN Affinity Capture-MS physical 15717329 KRT14 Affinity Capture-MS physical 15717329 AMHR2 Affinity Capture-MS physical 15717329 IRS4 Affinity Capture-MS physical 15717329 PTK2B Affinity Capture-MS physical 15717329 CRKL Affinity Capture-MS physical 15717329 MAP2K6 Affinity Capture-MS physical 15717329 PKN2 Affinity Capture-MS physical 15717329 PDGFRA Affinity Capture-MS physical 15717329 PINK1 Affinity Capture-MS physical 15717329 CSNK2A1 Affinity Capture-MS physical 15717329 SC65 Affinity Capture-MS physical 15717329 PTPN14 Affinity Capture-MS physical 15717329 TCEB3C Affinity Capture-MS physical 15717329 BAP1 Affinity Capture-MS physical 15717329 WWP2 Affinity Capture-MS physical 15717329 MED12 Affinity Capture-MS physical 15717329 ZNF787 Affinity Capture-MS physical 15717329 FBN2 Affinity Capture-MS physical 15717329 TTBK2 Affinity Capture-MS physical 15717329 RPL14 Affinity Capture-MS physical 15717329 EEF1A2 Affinity Capture-MS physical 15717329 CCNE2 Affinity Capture-MS physical 15717329 FRK Affinity Capture-MS physical 19345329 FRK Affinity Capture-Western physical 19345329 FRK Affinity Capture-Western physical 19345329 NEDD4 Affinity Capture-Western physical 19345329 UBC Affinity Capture-Western physical 19345329 NDFIP1 Affinity Capture-Western physical 22213801 NDFIP1 Affinity Capture-Western physical 22213801 UBC Affinity Capture-Western physical 22213801 AKT1 Affinity Capture-Western physical 20605778 UBC Affinity Capture-Western physical 20605778 PPP3CA Affinity Capture-Western physical 20605778 EGR1 Affinity Capture-Western physical 21354147