| Entrez gene ID | | 5781 |
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| Official gene symbol | | PTPN11 |
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| Full name | | protein tyrosine phosphatase, non-receptor type 11 |
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| Aliases | | ,BPTP3,CFC,MGC14433,NS1,PTP-1D,PTP2C,SH-PTP2,SH-PTP3,SHP2, |
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| Gene summary | | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq] |
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| Location | | Chromosome: 12 Locus: 12q24 |
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| Gene position | | 112856536 - 112947717 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 91182 bp |
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| Gene sequence |
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| OMIM ID | | 176876 |
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