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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for PTPN11 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0007173 epidermal growth factor receptor signaling pathway TAS GO:0007411 axon guidance TAS GO:0007596 blood coagulation TAS GO:0008286 insulin receptor signaling pathway TAS GO:0008543 fibroblast growth factor receptor signaling pathway TAS GO:0019221 cytokine-mediated signaling pathway TAS GO:0030168 platelet activation TAS GO:0031295 T cell costimulation TAS GO:0033628 regulation of cell adhesion mediated by integrin IMP GO:0034329 cell junction assembly TAS GO:0035335 peptidyl-tyrosine dephosphorylation IMP GO:0035335 peptidyl-tyrosine dephosphorylation TAS GO:0048013 ephrin receptor signaling pathway IDA GO:0050900 leukocyte migration TAS GO:0060333 interferon-gamma-mediated signaling pathway TAS GO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS GO:0060337 type I interferon-mediated signaling pathway TAS GO:0060338 regulation of type I interferon-mediated signaling pathway TAS cellular_component GO:0005737 cytoplasm IDA GO:0005829 cytosol TAS molecular_function GO:0004725 protein tyrosine phosphatase activity TAS GO:0004726 non-membrane spanning protein tyrosine phosphatase activity IMP GO:0004726 non-membrane spanning protein tyrosine phosphatase activity TAS GO:0005515 protein binding IPI GO:0016787 hydrolase activity IEA

Protein-protein interaction details for PTPN11 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID SYNCRIP Two-hybrid physical 9847309 EGFR Affinity Capture-MS physical 16729043 ERBB2 Affinity Capture-MS physical 16729043 ERBB4 Affinity Capture-MS physical 16729043 TREML1 Affinity Capture-Western physical 15128762 BTLA Affinity Capture-Western physical 12796776 CSF2RB Affinity Capture-Western physical 9162089 CSF2RB Reconstituted Complex physical 9162089 STAT3 Affinity Capture-Western physical 11594781 FRS2 Two-hybrid physical 10650943 FRS2 Affinity Capture-Western physical 10650943 IRS2 Affinity Capture-Western physical 8910607 GRB2 Affinity Capture-Western physical 10747947 ROS1 Two-hybrid physical 11266449 PDGFRB Two-hybrid physical 11266449 GRB2 Affinity Capture-Western physical 8041791 STAT5A Reconstituted Complex physical 10617656 STAT5B Reconstituted Complex physical 10617656 STAT5A Biochemical Activity physical 10617656 STAT5B Biochemical Activity physical 10617656 INSR Reconstituted Complex physical 8135823 CSF3R Far Western physical 9824671 GRB2 Far Western physical 9824671 JAK1 Reconstituted Complex physical 8995399 JAK2 Reconstituted Complex physical 8995399 JAK1 Biochemical Activity physical 8995399 JAK2 Biochemical Activity physical 8995399 GRB2 Reconstituted Complex physical 8995399 IL4R Reconstituted Complex physical 11714803 IL6ST Affinity Capture-Western physical 12403768 SOCS3 Affinity Capture-Western physical 12403768 JAK1 Affinity Capture-Western physical 12403768 SOCS3 Reconstituted Complex physical 12403768 PLCG2 Affinity Capture-Western physical 12135708 PLCG2 Affinity Capture-Western physical 12135708 GAB2 Affinity Capture-Western physical 12135708 GAB2 Affinity Capture-Western physical 12135708 GRB2 Reconstituted Complex physical 9362449 IRS1 Reconstituted Complex physical 8505282 GAB3 Affinity Capture-Western physical 11739737 GAB3 Affinity Capture-Western physical 11739737 IRS1 Affinity Capture-Western physical 9756938 IGF1R Affinity Capture-Western physical 10082579 PTK2 Affinity Capture-Western physical 10082579 KIT Reconstituted Complex physical 7523381 EPHA2 Affinity Capture-Western physical 10655584 SLAMF1 Affinity Capture-Western physical 11806999 INPP5D Affinity Capture-Western physical 9110989 PECAM1 Affinity Capture-Western physical 10801826 SELE Affinity Capture-Western physical 11602579 GAB1 Affinity Capture-Western physical 11940581 CAV1 Affinity Capture-Western physical 12176037 EGFR Affinity Capture-Western physical 7673163 CD33 Affinity Capture-Western physical 10206955 CD33 Reconstituted Complex physical 10206955 BCAR1 Affinity Capture-Western physical 9188452 C6orf25 Affinity Capture-Western physical 11544253 EPOR Affinity Capture-Western physical 8639815 JAK2 Biochemical Activity physical 8639815 CDH5 Affinity Capture-Western physical 10681592 CTNNB1 Affinity Capture-Western physical 10681592 LAIR1 Affinity Capture-Western physical 10903717 PILRA Affinity Capture-Western physical 10903717 GRB2 Affinity Capture-Western physical 10212213 FYN Affinity Capture-Western physical 10212213 GAB2 Affinity Capture-Western physical 11782427 FRS2 Affinity Capture-Western physical 11360177 KIT Affinity Capture-Western physical 9528781 SLAMF1 Affinity Capture-Western physical 11689425 CD84 Affinity Capture-Western physical 11689425 LY9 Affinity Capture-Western physical 11689425 PIK3R1 Affinity Capture-Western physical 9918857 PECAM1 Reconstituted Complex physical 10350061 PECAM1 Far Western physical 10350061 PDGFRB Reconstituted Complex physical 7691811 PECAM1 Affinity Capture-Western physical 9774457 PECAM1 Reconstituted Complex physical 9774457 PECAM1 Reconstituted Complex physical 9054388 PECAM1 Affinity Capture-Western physical 9054388 PRLR Affinity Capture-Western physical 10991949 SLAMF6 Affinity Capture-Western physical 11489943 LAIR1 Affinity Capture-Western physical 9285412 FRS2 Affinity Capture-Western physical 9632781 GRB2 Affinity Capture-Western physical 9632781 SOS1 Affinity Capture-Western physical 9632781 FRS2 Far Western physical 9632781 MPZL1 Affinity Capture-Western physical 9792637 SIGLEC11 Affinity Capture-Western physical 11986327 STAT5A Affinity Capture-Western physical 12060651 IL6ST Affinity Capture-Western physical 10946280 PTK2B Affinity Capture-Western physical 10880513 PTK2B Affinity Capture-Western physical 10880513 PTK2B Far Western physical 10880513 PTK2B Biochemical Activity physical 10880513 GHR Reconstituted Complex physical 10976913 CRKL Affinity Capture-Western physical 9344843 SOS1 Affinity Capture-Western physical 9344843 LILRB4 Protein-peptide physical 9973385 IL6ST Affinity Capture-Western physical 9388212 FCRL3 Reconstituted Complex physical 12051764 GRB2 Affinity Capture-Western physical 10080542 GHR Reconstituted Complex physical 9632636 GRB2 Affinity Capture-Western physical 8702859 CEACAM1 Affinity Capture-Western physical 9867848 CEACAM1 Reconstituted Complex physical 9867848 GAB2 Affinity Capture-Western physical 10391903 GAB2 Affinity Capture-Western physical 11334882 GAB2 Two-hybrid physical 11334882 SIT1 Affinity Capture-Western physical 10209036 IGF1R Affinity Capture-Western physical 7642582 IGF1R Reconstituted Complex physical 7642582 JAK2 Affinity Capture-Western physical 8912646 INSR Affinity Capture-Western physical 7493946 INSR Reconstituted Complex physical 7493946 FCGR2B Affinity Capture-Western physical 10382761 GAB1 Two-hybrid physical 9658397 PTPN11 Two-hybrid physical 9847309 CBL Affinity Capture-Western physical 18519587 CBL Affinity Capture-Western physical 18519587 GAB2 Affinity Capture-Western physical 10871282