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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PTPRC (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5788
Official gene symbolPTPRC
Full nameprotein tyrosine phosphatase, receptor type, C
Aliases,B220,CD45,CD45R,GP180,LCA,LY5,T200,
Gene summaryThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq]
LocationChromosome: 1   Locus: 1q31-q32
Gene position198608137 - 198726545  Map Viewer
Gene orientationplus
Gene size118409 bp
Gene sequence
OMIM ID151460