Entrez gene ID | | 58484 |
Official gene symbol | | NLRC4 |
Full name | | NLR family, CARD domain containing 4 |
Aliases | | ,CARD12,CLAN,CLAN1,CLANA,CLANB,CLANC,CLAND,CLR2.1,IPAF, |
Gene summary | | In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM] |
Location | | Chromosome: 2 Locus: 2p22-p21 |
Gene position | | 32490801 - 32449518 Map Viewer |
Gene orientation | | minus |
Gene size | | 41284 bp |
Gene sequence |
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OMIM ID | | 606831 |
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