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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for NLRC4 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID58484
Official gene symbolNLRC4
Full nameNLR family, CARD domain containing 4
Aliases,CARD12,CLAN,CLAN1,CLANA,CLANB,CLANC,CLAND,CLR2.1,IPAF,
Gene summaryIn C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM]
LocationChromosome: 2   Locus: 2p22-p21
Gene position32490801 - 32449518  Map Viewer
Gene orientationminus
Gene size41284 bp
Gene sequence
OMIM ID606831