Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for RB1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5925
Official gene symbolRB1
Full nameretinoblastoma 1
Aliases,OSRC,RB,p105-Rb,pRb,pp110,
Gene summaryThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq]
LocationChromosome: 13   Locus: 13q14.2
Gene position48877883 - 49056026  Map Viewer
Gene orientationplus
Gene size178144 bp
Gene sequence
OMIM ID180200