Entrez gene ID | | 5925 |
Official gene symbol | | RB1 |
Full name | | retinoblastoma 1 |
Aliases | | ,OSRC,RB,p105-Rb,pRb,pp110, |
Gene summary | | The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq] |
Location | | Chromosome: 13 Locus: 13q14.2 |
Gene position | | 48877883 - 49056026 Map Viewer |
Gene orientation | | plus |
Gene size | | 178144 bp |
Gene sequence |
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OMIM ID | | 180200 |
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