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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for RB1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000075 cell cycle checkpoint TAS GO:0000080 G1 phase of mitotic cell cycle TAS GO:0000082 G1/S transition of mitotic cell cycle TAS GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle TAS GO:0000084 S phase of mitotic cell cycle TAS GO:0000278 mitotic cell cycle TAS GO:0000279 M phase NAS GO:0006338 chromatin remodeling TAS GO:0006351 transcription, DNA-dependent TAS GO:0006355 regulation of transcription, DNA-dependent NAS GO:0006469 negative regulation of protein kinase activity IPI GO:0007050 cell cycle arrest TAS GO:0007265 Ras protein signal transduction IEP GO:0007346 regulation of mitotic cell cycle IMP GO:0016310 phosphorylation TAS GO:0030182 neuron differentiation IEA GO:0030308 negative regulation of cell growth TAS GO:0030521 androgen receptor signaling pathway NAS GO:0031134 sister chromatid biorientation IMP GO:0031175 neuron projection development IEA GO:0031575 mitotic cell cycle G1/S transition checkpoint TAS GO:0034088 maintenance of mitotic sister chromatid cohesion IMP GO:0042551 neuron maturation IEA GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity TAS GO:0043550 regulation of lipid kinase activity IDA GO:0044419 interspecies interaction between organisms IEA GO:0045445 myoblast differentiation IMP GO:0045749 negative regulation of S phase of mitotic cell cycle TAS GO:0045842 positive regulation of mitotic metaphase/anaphase transition IMP GO:0045879 negative regulation of smoothened signaling pathway IEA GO:0045892 negative regulation of transcription, DNA-dependent IDA GO:0045892 negative regulation of transcription, DNA-dependent TAS GO:0045893 positive regulation of transcription, DNA-dependent NAS GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0048565 digestive tract development IEA GO:0048667 cell morphogenesis involved in neuron differentiation IEA GO:0050680 negative regulation of epithelial cell proliferation IEA GO:0051146 striated muscle cell differentiation IEA GO:0051301 cell division IEA GO:0051318 G1 phase TAS GO:0051402 neuron apoptosis IEA GO:0051726 regulation of cell cycle IEA GO:0071459 protein localization to chromosome, centromeric region IMP GO:0071922 regulation of cohesin localization to chromatin IMP GO:0071930 negative regulation of transcription involved in G1/S phase of mitotic cell cycle IEA GO:0090230 regulation of centromere complex assembly TAS cellular_component GO:0000785 chromatin TAS GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005634 nucleus NAS GO:0005654 nucleoplasm TAS GO:0005819 spindle IEA GO:0016514 SWI/SNF complex TAS GO:0016605 PML body IDA GO:0035189 Rb-E2F complex TAS molecular_function GO:0001102 RNA polymerase II activating transcription factor binding IEA GO:0003674 molecular_function ND GO:0003677 DNA binding IEA GO:0003700 sequence-specific DNA binding transcription factor activity TAS GO:0003713 transcription coactivator activity NAS GO:0005515 protein binding IPI GO:0008134 transcription factor binding IPI GO:0016301 kinase activity TAS GO:0019900 kinase binding IDA GO:0031625 ubiquitin protein ligase binding IPI GO:0050681 androgen receptor binding NAS GO:0051219 phosphoprotein binding IPI

Protein-protein interaction details for RB1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID CUX1 Two-hybrid physical 12891711 MCM7 Two-hybrid physical 9566894 HBP1 Two-hybrid physical 9178770 TRAP1 Two-hybrid physical 8756626 AATF Two-hybrid physical 12450794 THOC1 Two-hybrid physical 7525595 LIN9 Affinity Capture-Western physical 15538385 LIN9 Reconstituted Complex physical 15538385 BRCA1 Affinity Capture-Western physical 10518542 BRCA1 Reconstituted Complex physical 10518542 ABL1 Affinity Capture-Western physical 9071815 BCR Affinity Capture-Western physical 9071815 NCOA6 Two-hybrid physical 14645241 BAG1 Affinity Capture-Western physical 12845674 BRCA1 Affinity Capture-Western physical 11521194 BRCA1 Co-localization physical 11521194 BRCA1 Reconstituted Complex physical 11521194 RBBP8 Affinity Capture-Western physical 10779361 HDAC1 Affinity Capture-Western physical 10779361 AR Reconstituted Complex physical 9813067 NCOA6 Affinity Capture-Western physical 14645241 NCOA6 Reconstituted Complex physical 14645241 MORF4L2 Reconstituted Complex physical 14506250 SERPINB2 Affinity Capture-Western physical 12944478 SERPINB2 Reconstituted Complex physical 12944478 CUX1 Reconstituted Complex physical 12891711 CUX1 Affinity Capture-Western physical 12891711 TP73 Affinity Capture-Western physical 12761493 GNB2L1 Affinity Capture-Western physical 12761493 CBX1 Reconstituted Complex physical 12711675 PELP1 Affinity Capture-Western physical 12682072 PELP1 Reconstituted Complex physical 12682072 PIK3R3 Affinity Capture-Western physical 12588990 PIK3R3 Reconstituted Complex physical 12588990 PPARG Affinity Capture-Western physical 12479814 PPARG Reconstituted Complex physical 12479814 PPARG Reconstituted Complex physical 12479814 HDAC3 Affinity Capture-Western physical 12479814 RBBP4 Affinity Capture-Western physical 11470869 E2F1 Affinity Capture-Western physical 11470869 MORF4L1 Reconstituted Complex physical 11500496 MRFAP1 Affinity Capture-Western physical 11500496 MORF4L1 Affinity Capture-Western physical 11500496 MRFAP1 Affinity Capture-Western physical 11500496 MORF4L1 Co-purification physical 12397079 MRFAP1 Co-purification physical 12397079 MORF4L1 Affinity Capture-Western physical 12397079 E2F1 Affinity Capture-Western physical 12397079 MORF4L1 Affinity Capture-Western physical 12397079 BRCA1 Reconstituted Complex physical 10220405 RBBP7 Reconstituted Complex physical 10220405 HDAC1 Reconstituted Complex physical 10615135 HDAC1 Reconstituted Complex physical 11684023 HDAC1 Reconstituted Complex physical 11684023 CDK2 Biochemical Activity physical 10938106 HDAC1 Affinity Capture-Western physical 12466959 HDAC1 Affinity Capture-Western physical 9491888 HDAC1 Affinity Capture-Western physical 9491888 DNMT1 Co-fractionation physical 10888886 DNMT1 Reconstituted Complex physical 10888886 DNMT1 Affinity Capture-Western physical 10888886 HDAC1 Affinity Capture-Western physical 10490602 HDAC2 Affinity Capture-Western physical 10490602 HDAC3 Affinity Capture-Western physical 10490602 ARID4A Affinity Capture-Western physical 10490602 HDAC1 Affinity Capture-Western physical 10490602 HDAC2 Affinity Capture-Western physical 10490602 HDAC3 Affinity Capture-Western physical 10490602 ARID4A Affinity Capture-Western physical 10490602 RBL1 Affinity Capture-Western physical 10490602 RBL2 Affinity Capture-Western physical 10490602 NFIX Affinity Capture-Western physical 11896613 SP1 Affinity Capture-Western physical 11896613 HDAC1 Reconstituted Complex physical 9724731 SMARCA4 Affinity Capture-Western physical 7923370 RBBP7 Affinity Capture-Western physical 7503932 RBBP4 Affinity Capture-Western physical 7503932 RBBP7 Reconstituted Complex physical 7503932 RBBP4 Affinity Capture-Western physical 10734134 RBBP4 Reconstituted Complex physical 10734134 MYOD1 Reconstituted Complex physical 11285237 DNMT3A Reconstituted Complex physical 11350943 EID1 Reconstituted Complex physical 11073989 EID1 Affinity Capture-Western physical 11073989 EID1 Two-hybrid physical 11073990 EID1 Reconstituted Complex physical 11073990 EID1 Affinity Capture-Western physical 11073990 EID1 Affinity Capture-Western physical 11073990 BRF1 Affinity Capture-Western physical 11997511 PRDM2 Reconstituted Complex physical 7538672 PRDM2 Affinity Capture-Western physical 7538672 SUV39H1 Affinity Capture-Western physical 11484059 SUV39H1 Affinity Capture-Western physical 11484059 CBX5 Affinity Capture-Western physical 11484059 SUV39H1 Affinity Capture-Western physical 11533237 SUV39H1 Affinity Capture-Western physical 11533237 SUV39H1 Reconstituted Complex physical 11533237 CBX4 Phenotypic Enhancement genetic 11583618 RING1 Affinity Capture-Western physical 11583618 CBX4 Affinity Capture-Western physical 11583618 VDR Reconstituted Complex physical 11358960 KDM5A Affinity Capture-Western physical 11358960 KDM5A Reconstituted Complex physical 7935440 KDM5A Affinity Capture-Western physical 7935440 CCND3 Two-hybrid physical 17972097 E2F1 Reconstituted Complex physical 8896460 PML Affinity Capture-Western physical 9448006 PML Affinity Capture-Western physical 9448006 PML Reconstituted Complex physical 9448006 CCND1 Reconstituted Complex physical 11126356 CCND1 Phenotypic Suppression genetic 11126356 TAF1 Phenotypic Suppression genetic 11126356 TAF1 Reconstituted Complex physical 11126356 PA2G4 Affinity Capture-Western physical 11268000 PA2G4 Reconstituted Complex physical 11268000 TMPO Affinity Capture-Western physical 12475961 CCND1 Affinity Capture-Western physical 8490963 MYC Two-hybrid physical 7838535 AATF Affinity Capture-Western physical 12450794 AATF Affinity Capture-Western physical 12450794 TGM2 Affinity Capture-Western physical 9315663 POLA1 Affinity Capture-Western physical 9395244 POLA1 Co-purification physical 9395244 ABL1 Reconstituted Complex physical 8242749 FRK Reconstituted Complex physical 7664264 FRK Affinity Capture-Western physical 7664264 ATF2 Reconstituted Complex physical 1641004 SNW1 Reconstituted Complex physical 12466551 SNW1 Reconstituted Complex physical 12466551 ARID3B Reconstituted Complex physical 10446990 MYOD1 Reconstituted Complex physical 8381715 MYOD1 Affinity Capture-Western physical 8381715 MCM7 Reconstituted Complex physical 9566894 MCM7 Two-hybrid physical 9566894 SNAPC1 Affinity Capture-Western physical 11094070 SNAPC3 Reconstituted Complex physical 11094070 SNAPC1 Reconstituted Complex physical 11094070 SNAPC1 Reconstituted Complex physical 11094070 SNAPC3 Reconstituted Complex physical 11094070 TAF1 Reconstituted Complex physical 7724524 TAF1 Affinity Capture-Western physical 7724524 CCNT2 Reconstituted Complex physical 12037672 CCNT2 Reconstituted Complex physical 12037672 CDK9 Reconstituted Complex physical 12037672 CDK9 Affinity Capture-Western physical 12037672 RAF1 Reconstituted Complex physical 9819434 RAF1 Two-hybrid physical 9819434 RAF1 Affinity Capture-Western physical 9819434 E2F1 Two-hybrid physical 10869426 E2F4 Two-hybrid physical 10869426 E4F1 Two-hybrid physical 10869426 E4F1 Reconstituted Complex physical 10869426 E4F1 Affinity Capture-Western physical 10869426 TAF1 Reconstituted Complex physical 9858607 ENC1 Affinity Capture-Western physical 9566959 ENC1 Reconstituted Complex physical 9566959 RFC1 Affinity Capture-Western physical 10353443 LMNA Reconstituted Complex physical 8278403 PRKRA Reconstituted Complex physical 9010216 PRKRA Affinity Capture-Western physical 9010216 E2F1 Reconstituted Complex physical 8230483 E2F1 Affinity Capture-Western physical 8230483 CREG1 Reconstituted Complex physical 9710587 CEBPB Reconstituted Complex physical 11596110 HBP1 Reconstituted Complex physical 9178770 HBP1 Affinity Capture-Western physical 9178770 HMGB1 Reconstituted Complex physical 11748221 PHB Affinity Capture-Western physical 10523633 RAF1 Reconstituted Complex physical 10523633 MDM2 Reconstituted Complex physical 10078201 JUN Affinity Capture-Western physical 10026157 JUN Reconstituted Complex physical 10026157 JUN Two-hybrid physical 10026157 PAX6 Reconstituted Complex physical 10359315 MNAT1 Reconstituted Complex physical 11113200 RBBP5 Reconstituted Complex physical 7558034 E2F2 Co-crystal Structure physical 12502741 E2F2 Reconstituted Complex physical 12502741 TRAP1 Reconstituted Complex physical 8756626 TRAP1 Affinity Capture-Western physical 8756626 TRAP1 Affinity Capture-Western physical 8756626 TRIP11 Two-hybrid physical 9256431 TRIP11 Affinity Capture-Western physical 9256431 TRIP11 Reconstituted Complex physical 9256431 UBTF Affinity Capture-Western physical 11042686 UBTF Affinity Capture-Western physical 11042686 UBTF Reconstituted Complex physical 11042686 UBTF Reconstituted Complex physical 11042686 AHR Affinity Capture-Western physical 9712901 ARNT Affinity Capture-Western physical 9712901 AHR Two-hybrid physical 9712901 AHR Reconstituted Complex physical 9712901 AATF Reconstituted Complex physical 10783144 AATF Affinity Capture-Western physical 10783144 AATF Affinity Capture-Western physical 10783144 AATF Reconstituted Complex physical 10783144 AR Reconstituted Complex physical 9675141 AR Two-hybrid physical 9675141 THOC1 Reconstituted Complex physical 7525595 CCNA1 Reconstituted Complex physical 10022926 CCNA1 Affinity Capture-Western physical 10022926 E2F1 Reconstituted Complex physical 7739537 TFDP1 Affinity Capture-Western physical 7739537 TFDP2 Affinity Capture-Western physical 7739537 E2F1 Two-hybrid physical 9422723 RBBP9 Two-hybrid physical 9697699 RBBP9 Affinity Capture-Western physical 9697699 TAF1 Affinity Capture-Western physical 9242374 TAF1 Reconstituted Complex physical 9242374 TBP Reconstituted Complex physical 9242374 BRF1 Reconstituted Complex physical 10330166 BRF1 Affinity Capture-Western physical 10330166 PHB Reconstituted Complex physical 10376528 PHB Affinity Capture-Western physical 10376528 USP4 Reconstituted Complex physical 11571651 USP4 Affinity Capture-Western physical 11571651 RBBP8 Two-hybrid physical 9721205 RBBP8 Affinity Capture-Western physical 9721205 HDAC1 Affinity Capture-Western physical 12473678 E2F1 Affinity Capture-Western physical 12963846 L3MBTL Affinity Capture-Western physical 17540172 L3MBTL2 Affinity Capture-Western physical 17540172 SMARCA4 Co-fractionation physical 9128241 AURKB Reconstituted Complex physical 19225156 AURKB Biochemical Activity physical 19225156 AURKB Affinity Capture-Western physical 19225156 CDK2 Biochemical Activity physical 19225156 CDK4 Biochemical Activity physical 19225156 SMARCA4 Affinity Capture-Western physical 19081374 HDAC1 Affinity Capture-Western physical 19081374 PPA1 Affinity Capture-Western physical 17008050 AR Affinity Capture-Western physical 16964284 PHB Affinity Capture-Western physical 16964284 MCM7 Affinity Capture-Western physical 16912045 ZBTB7A Affinity Capture-Western physical 18801742 ZBTB7A Affinity Capture-Western physical 18801742 SKP2 Affinity Capture-Western physical 15469821 SKP2 Affinity Capture-Western physical 15469821 HMGA2 Affinity Capture-Western physical 16766265 HMGA2 Reconstituted Complex physical 16766265 HMGA2 Far Western physical 16766265 E2F1 Affinity Capture-Western physical 16766265 HDAC1 Affinity Capture-Western physical 16766265 E2F1 Affinity Capture-Western physical 16766265 KDM5B Affinity Capture-Western physical 16645588 KDM5B Affinity Capture-Western physical 16645588 RBBP8 Affinity Capture-Western physical 16581787 SERPINB2 Affinity Capture-Western physical 16397580 SERPINB2 Affinity Capture-Western physical 16397580 EID1 Reconstituted Complex physical 11964378 DNMT1 Reconstituted Complex physical 11847125 DNMT1 Affinity Capture-Western physical 11847125 E2F1 Affinity Capture-Western physical 11839806 HDAC1 Affinity Capture-Western physical 11839806 KDM4A Affinity Capture-Western physical 15927959 KDM4A Two-hybrid physical 15927959 STAT3 Affinity Capture-Western physical 15677471 STAT3 Affinity Capture-Western physical 15677471 STAT3 Co-localization physical 15677471 STAT3 Reconstituted Complex physical 15677471 E2F1 Affinity Capture-Western physical 15670817 CCND1 Reconstituted Complex physical 11593423 HDAC2 Reconstituted Complex physical 11593423 HDAC1 Affinity Capture-Western physical 11583987 HDAC2 Affinity Capture-Western physical 11583987 KDM1A Affinity Capture-Western physical 18216119 KDM1A Affinity Capture-Western physical 18216119 E2F1 Affinity Capture-Western physical 18216119 RAF1 Reconstituted Complex physical 15485920 RAF1 Reconstituted Complex physical 15485920 RAF1 Affinity Capture-Western physical 15485920 CCND1 Affinity Capture-Western physical 15485920 E2F1 Affinity Capture-Western physical 15485920 CCND1 Biochemical Activity physical 15485920 RAF1 Biochemical Activity physical 15485920 SMARCA4 Affinity Capture-Western physical 15485920 HDAC1 Affinity Capture-Western physical 15485920 CBX5 Affinity Capture-Western physical 15485920 ARID4A Affinity Capture-Western physical 11283269 ARID4A Affinity Capture-Western physical 11283269 RBBP7 Affinity Capture-Western physical 11283269 RBBP4 Affinity Capture-Western physical 11283269 LIN9 Reconstituted Complex physical 15479636 LIN54 Reconstituted Complex physical 15479636 SP1 Affinity Capture-Western physical 11158299 HDAC1 Affinity Capture-Western physical 11158299 HDAC1 Affinity Capture-Western physical 10958676 HDAC3 Affinity Capture-Western physical 10958676 SMARCA4 Affinity Capture-Western physical 10778858 SMARCA4 Affinity Capture-Western physical 10778858 HDAC1 Affinity Capture-Western physical 10778858 SKI Affinity Capture-Western physical 9988677 SKIL Affinity Capture-Western physical 9988677 HDAC1 Reconstituted Complex physical 9988677 KAT2B Affinity Capture-Western physical 15044952 KAT2B Affinity Capture-Western physical 15044952 KAT2B Reconstituted Complex physical 15044952 MDM2 Affinity Capture-Western physical 15044952 HDAC1 Affinity Capture-Western physical 15044952 EID1 Affinity Capture-Western physical 15044952 E2F4 Affinity Capture-Western physical 9858615 FOXM1 Affinity Capture-Western physical 15024056 HDAC1 Reconstituted Complex physical 15003538 CDK4 Biochemical Activity physical 15003538 CDK2 Biochemical Activity physical 15003538 HDAC1 Affinity Capture-Western physical 9468140 HDAC1 Reconstituted Complex physical 9468140 HDAC1 Reconstituted Complex physical 9468139 HDAC1 Affinity Capture-Western physical 9468139 HDAC1 Affinity Capture-Western physical 9468139 HDAC1 Affinity Capture-Western physical 17827154 HDAC2 Affinity Capture-Western physical 17827154 USP4 Affinity Capture-Western physical 11571652 USP4 Reconstituted Complex physical 11571652 USP4 Co-fractionation physical 11571652 SMARCA4 Affinity Capture-Western physical 17666433 YY1 Affinity Capture-Western physical 17287852 DNAJA2 Affinity Capture-Western physical 17242198 DNAJA2 Affinity Capture-Western physical 17242198 PRDM2 Protein-peptide physical 9223517 PRDM2 Reconstituted Complex physical 9223517 SMYD2 Biochemical Activity physical 20870719 SMYD2 Reconstituted Complex physical 20870719 SMYD2 Affinity Capture-Western physical 20870719 RBBP7 Reconstituted Complex physical 2005966 ARID4A Reconstituted Complex physical 21148318 ARID4A Affinity Capture-Western physical 21148318 UHRF2 Far Western physical 21952639 UHRF2 Affinity Capture-Western physical 21952639 UHRF2 Affinity Capture-Western physical 21952639 UHRF2 Reconstituted Complex physical 21952639 TAL1 Affinity Capture-MS physical 19497860 TAL1 Affinity Capture-Western physical 10866689 TAL1 Affinity Capture-Western physical 10866689 TCF3 Affinity Capture-Western physical 10866689 TCF3 Affinity Capture-Western physical 10866689 LMO2 Affinity Capture-Western physical 10866689 LDB1 Affinity Capture-Western physical 10866689 IRF3 Affinity Capture-MS physical 21903422 IRF3 Reconstituted Complex physical 21903422 SP1 Affinity Capture-Western physical 10850422