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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for UPF1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5976
Official gene symbolUPF1
Full nameUPF1 regulator of nonsense transcripts homolog (yeast)
Aliases,FLJ43809,FLJ46894,HUPF1,KIAA0221,NORF1,RENT1,pNORF1,
Gene summaryThis gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. [provided by RefSeq]
LocationChromosome: 19   Locus: 19p13.2-p13.11
Gene position18942744 - 18979039  Map Viewer
Gene orientationplus
Gene size36296 bp
Gene sequence
OMIM ID601430