Entrez gene ID | | 5976 |
Official gene symbol | | UPF1 |
Full name | | UPF1 regulator of nonsense transcripts homolog (yeast) |
Aliases | | ,FLJ43809,FLJ46894,HUPF1,KIAA0221,NORF1,RENT1,pNORF1, |
Gene summary | | This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. [provided by RefSeq] |
Location | | Chromosome: 19 Locus: 19p13.2-p13.11 |
Gene position | | 18942744 - 18979039 Map Viewer |
Gene orientation | | plus |
Gene size | | 36296 bp |
Gene sequence |
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OMIM ID | | 601430 |
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