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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for BCR (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID613
Official gene symbolBCR
Full namebreakpoint cluster region
Aliases,ALL,BCR1,CML,D22S11,D22S662,FLJ16453,PHL,
Gene summaryA reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 22   Locus: 22q11|22q11.23
Gene position23522552 - 23660224  Map Viewer
Gene orientationplus
Gene size137673 bp
Gene sequence
OMIM ID151410